Association of-174G/C interleukin-6 gene polymorphism with the risk of chronic lymphocytic, chronic myelogenous and acute myelogenous leukemias in Turkish patients

2014-07-01
Mutlu, Pelin
Elci, Pinar
Yildirim, Murat
Cetin, A. Turker
Avcu, Ferit
Purpose: The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia (AML) in Turkish patients.
JOURNAL OF BUON

Suggestions

Identification of polymorphisms on the MDR1 gene among Turkish population and their effects on multidrug resistance in acute leukemia patients
Kaya, P; Gündüz, Ufuk; Arpaci, F; Ural, AU; Guran, S (2005-09-01)
Multidrug-resistance (MDR) phenotype is a serious limitation to the effective chemotherapeutic treatment of many cancer types, including leukemia. One of the most important proteins, the over-expression of which is responsible for the multidrug-resistance phenotype in many cancer types, is P-glycoprotein. This protein is the product of the MDR1 gene. In previous studies, single-nucleotide polymorphisms (SNPs) C3435T, G2677T, and T-129C in the MDR1 gene were shown to be correlated with lower P-glycoprotein e...
ASSOCIATION OF FLT3 AND NPM1 MUTATIONS IN ACUTE MYELOID LEUKEMIA PATIENTS WITH METABOLOMIC PATTERNS DETERMINED BY MASS SPECTROMETRY
Gerekci Yeşilyurt, Selin; Özen, Can; Özçubukçu, Salih; Department of Biochemistry (2022-8-29)
Acute Myeloid Leukemia is a hematological cancer with high phenotypic and genotypic heterogeneity. Patients diagnosed with AML are categorized into risk groups based on cytogenetic and molecular abnormality tests, which determine the specific treatment regimes. Since risk status determination takes significant amount of time and some emergency patients require immediate treatment, a method to provide fast clinical data that will be the basis for initial treatment regime is needed in the medical commun...
Increased Serum Interleukin-23 Levels In Patients With Behcet Disease-Associated Uveitis
Gurses, Ozlem; Koc, Elcin Kartal (2014-04-01)
Purpose: The aim of this study is to compare the serum interleukin (IL) levels between the patients with extraocular manifestations of Behçet disease and Behçet disease-associated uveitis. Methods: This is a prospective study involving 12 patients with extraocular manifestations of Behçet disease and 16 patients with Behçet disease-associated uveitis. The patients are involved in this study according to declaration of Helsinki. Inclusion criteria for all patients consist of a positive HLA B51 tissue typing...
Studies directed towards The synthesis Of İmatinib Mesylate ((Gleevec), 4-(4-Methyl-Piperazin-1- Ylmethyl)-N-[4- Methyl-3-(4-Pyridin-3-Yl-Pyrimidin-2- Ylamino)-Phenyl]- Benzamide Methanesulfonate) Analogs
Günay, Neşet Batuhan; Demir, Ayhan Sıtkı; Department of Chemistry (2008)
Imatinib mesylate is indicated for the treatment of chronic myeloid leukemia (CML) and unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST). By the application of this anticancer drug, problems occurs in terms of stability and activity. Computer assisted design (CAD) works showed that the modification of the B and C part molecule can increase the effectivity of the drug. The new derivatives of the drug will be obtained to change some part of the B and C segments. The total synthes...
Investigation of the impacts of linkage disequilibrium on SNP selection studies
Kantar Özçırpan, Ekin; Weber, Gerhard Wilhelm; İyigün, Cem; Department of Biomedical Engineering (2015)
In many Genome Wide Association Studies (GWAS), the relation between SNPs and complex diseases has being tried to reveal. Moreover it is known that, in GWAS there exist a high amount of data which include relations between SNPs, phenotypes and diseases, etc. Many algorithms have been used to be able to reach the desired information from this huge data. Therefore, in this study, an algorithm one of whose important steps is based on linkage disequilibrium(LD), was constructed to eliminate the redundant inform...
Citation Formats
P. Mutlu, P. Elci, M. Yildirim, A. T. Cetin, and F. Avcu, “Association of-174G/C interleukin-6 gene polymorphism with the risk of chronic lymphocytic, chronic myelogenous and acute myelogenous leukemias in Turkish patients,” JOURNAL OF BUON, pp. 787–791, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/53517.