Firing coincidences between neighboring retinal ganglion cells: inside information or epiphenomenon?

Levine, MW
Castaldo, K
Kasapoglu, MB
Retinal ganglion cells often fire impulses in synchrony; is this synchronization an irrelevant by-product of processing shared inputs, or does it encode information? We examined the rate of occurrence of coincident impulses from pairs of ganglion cells responding to stimuli that varied along several dimensions. We find that coincidences convey little if any additional information about simple static stimuli beyond what could be determined from the firing rates of the two cells considered separately. In fact, at least one of the separate cells generally provided a better information channel than the coincidence rate, implying that under these conditions ganglion cells do not employ a strategy of encoding by coincidences. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.


Cancer onset and progression: A genome-wide, nonlinear dynamical systems perspective on onconetworks
Qu, K.; Haidar, A. Abi; Fan, J.; Ensman, L.; Tuncay, Kağan; Jolly, M.; Ortoleva, P. (Elsevier BV, 2007-05-21)
It is hypothesized that the many human cell types corresponding to multiple states is supported by an underlying nonlinear dynamical system (NDS) of transcriptional regulatory network (TRN) processes. This hypothesis is validated for epithelial cells whose TRN is found to support an extremely complex array of states that we term a "bifurcation nexus", for which we introduce a quantitative measure of complexity. The TRN used is constructed and analyzed by integrating a database of TRN information, cDNA micro...
Computational modeling of chemo-electro-mechanical coupling: A novel implicit monolithic finite element approach
Wong, J.; Göktepe, Serdar; Kuhl, E. (Wiley, 2013-10-01)
Computational modeling of the human heart allows us to predict how chemical, electrical, and mechanical fields interact throughout a cardiac cycle. Pharmacological treatment of cardiac disease has advanced significantly over the past decades, yet it remains unclear how the local biochemistry of an individual heart cell translates into global cardiac function. Here, we propose a novel, unified strategy to simulate excitable biological systems across three biological scales. To discretize the governing chemic...
The effect of diabetes on rat skeletal muscle tissues at molecular level
Bozkurt, Özlem; Severcan, Feride; Department of Biology (2006)
In the present study Fourier Transform Infrared Spectroscopy was used to examine the effects of streptozotocin-induced diabetes mellitus on the structural components of slow- and fast-twitch rat skeletal muscles, at molecular level. Diabetes mellitus is a chronic disorder of carbohydrate, fat and protein metabolism, which is characterized by hyperglycemia caused by a defective or deficient insulin secretory response. The effect of diabetes is seen on a variety of tissues leading to important secondary compl...
Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis
Yildiz, Gokhan; ARSLAN ERGÜL, AYÇA; Bagislar, Sevgi; KONU KARAKAYALI, ÖZLEN; Yuzugullu, Haluk; Gursoy-Yuzugullu, Ozge; Ozturk, Nuri; Özen, Çiğdem; ÖZDAĞ, Hilal; Erdal, Esra; KARADEMİR, SEDAT; SAĞOL, ÖZGÜL; Mizrak, Dilsa; BOZKAYA, HAKAN; İLK, HAKKI GÖKHAN; İlk Dağ, Özlem; Bilen, Biter; Atalay, Rengül; Akar, Nejat; Ozturk, Mehmet (Public Library of Science (PLoS), 2013-05-15)
Senescence is a permanent proliferation arrest in response to cell stress such as DNA damage. It contributes strongly to tissue aging and serves as a major barrier against tumor development. Most tumor cells are believed to bypass the senescence barrier (become "immortal") by inactivating growth control genes such as TP53 and CDKN2A. They also reactivate telomerase reverse transcriptase. Senescence-to-immortality transition is accompanied by major phenotypic and biochemical changes mediated by genome-wide t...
Two-dimensional multi-frequency imaging of a tumor inclusion in a homogeneous breast phantom using the harmonic motion Doppler imaging method
TAFRESHI, Azadeh Kamali; TOP, Can Baris; Gençer, Nevzat Güneri (IOP Publishing, 2017-06-21)
Harmonic motion microwave Doppler imaging (HMMDI) is a novel imaging modality for imaging the coupled electrical and mechanical properties of body tissues. In this paper, we used two experimental systems with different receiver configurations to obtain HMMDI images from tissue-mimicking phantoms at multiple vibration frequencies between 15 Hz and 35 Hz. In the first system, we used a spectrum analyzer to obtain the Doppler data in the frequency domain, while in the second one, we used a homodyne receiver th...
Citation Formats
M. Levine, K. Castaldo, and M. Kasapoglu, “Firing coincidences between neighboring retinal ganglion cells: inside information or epiphenomenon?,” BIOSYSTEMS, pp. 139–146, 2002, Accessed: 00, 2020. [Online]. Available: