Design and Development of a Low Cost Device for Bone Fracture Detection Using FFT Technique on MATLAB

2018-11-02
Qadir, Zakria
Ali, Muhammad
Nesimoglu, Tayfun
Bone fracture is a common problem in daily life which occurs when high pressure is applied on bone or by simple accident and also due to osteoporosis and bone cancer. Different techniques are used today to detect bone fractures such as X-Ray, Computed Tomography (CT-scan), Magnetic Resonance Imaging (MRI) and Ultrasound. Among these four modalities, X-ray diagnosis is commonly used for fracture detection. However, if the fracture is complicated, a CT scan or MRI may be needed for further diagnosis and operation. In this paper, it is intended to make a low-cost portable device for bone fracture detection of patients, having age between 15 to 45 years using sound waves generated by the vibrator of a mobile phone. FFT technique in MATLAB was applied to the generated sound waves to examine the difference between cracked and healthy bone by applying 200 Hz of the sampling frequency. The device will be useful for doctors and public alike since it is portable, practical, mobile and affordable. It must be noted that the proposed device is not intended for a replacement of standard methodologies like X-Ray but rather will serve to be used as an initial detection phase. It is hoped that a negative scan of this device will discount the need for the more costly and timeconsuming X-Ray procedure.

Suggestions

Development of a siRNA delivery system for the treatment of osteoporosis
Sezlev Bilecen, Deniz; Hasırcı, Vasıf Nejat; Uludağ, Hasan; Department of Biotechnology (2018)
Osteoporosis, the most common disease of bone, is a skeletal disorder associated with low bone mass, increase in bone fragility and in susceptibility to fractures. The high bone resorption rate is shown to be due to increased number and activity of the osteoclasts. Receptor Activator of Nuclear Factor kappa B (RANK)/ Receptor Activator of Nuclear Factor kappa B Ligand (RANKL) system plays a crucial role in osteoclast differentiation and bone remodeling. RANKL participates in differentiation and activation o...
Development of PEI-RANK siRNA Complex Loaded PLGA Nanocapsules for the Treatment of Osteoporosis
Bilecen, Deniz Sezlev; Uludag, Hasan; Hasırcı, Vasıf Nejat (2018-04-30)
Osteoporosis, which is characterized by low bone mineral density and susceptibility to fracture, is caused by increased osteoclastic activity. Receptor activator of nuclear factor kappa B ligand (RANKL)/RANK signaling plays an important role in osteoclast differentiation and activation. The current treatment strategies for osteoporosis do not directly address this underlying cause and generates undesired side effects. This led to emergence of controlled delivery systems to increase drug bioavailability and ...
Construction of a PLGA based, targeted siRNA delivery system for treatment of osteoporosis
Bilecen, Deniz Sezlev; Carlos Rodriguez-Cabello, Jose; Uludag, Hasan; Hasırcı, Vasıf Nejat (2017-01-01)
Osteoporosis, a systemic skeletal disorder, occurs when bone turnover balance is disrupted. With the identification of the genes involved in the pathogenesis of the disease, studies on development of new treatments has intensified. Shortinterfering RNA (siRNA)is used to knockdown disease related gene expressions. Targeting siRNA in vivo is challenging. The maintenance of therapeutic plasma level is hampered by clearance of siRNA from the body. Targeted systems are useful in increasing the drug concentration...
Development and characterization of (carbonated) hydroxyapatite, akermanite involving polycaprolactone scaffolds
Altunordu, Gerçem; Keskin, Dilek; Department of Biomedical Engineering (2019)
Bone tissue loss or damage can occur due to accidents, injuries and diseases (osteomyelitis, osteosarcaoma, osteoporosis, etc.). Bone tissue engineering (BTE) aims to develop biomaterials that enhance the regeneration of bone tissue. Therefore, scaffolds for BTE should be biocompatible and bioactive; enabling strong communication with bone tissue. Bioceramics are a group of biomaterials that resemble to native bone mineral and improve bioactivity of BTE scaffolds. Considering these hydroxyapatite (HA), carb...
Improvement of bioactivity with dual bioceramic incorporation to nanofibrous PCL scaffolds
Altunordu, Gercem; Tezcaner, Ayşen; Evis, Zafer; Keskin, Dilek (2023-03-01)
Bone tissue injuries, diseases or related clinical interventions require bone tissue engineering (BTE) approaches for regeneration of large bone defects, especially for compromised situations. Most BTE applications in literature focused on composites of polymers with a single type of bioceramic. However, native bone matrix has various inorganic components. Accordingly, this study aimed to investigate the use of dual bioceramics in BTE scaffolds prepared by wet-electrospinning of Poly-caprolactone (PCL) and ...
Citation Formats
Z. Qadir, M. Ali, and T. Nesimoglu, “Design and Development of a Low Cost Device for Bone Fracture Detection Using FFT Technique on MATLAB,” 2018, p. 321, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/66927.