Effects of prenatal exposure to alcohol on activity, anxiety, motor coordination, and memory in young adult Wistar rats

Dursun, I.
Jakubowska-Dogru, E.
Uzbay, T.
The objective of the present study was to examine the effects of prenatal exposure to ethanol on motor performance, emotionality, learning and memory in young-adult, male Wistar rats. Alcohol was delivered to the pregnant dams intragastrically, throughout gestation days (GD) 7-20, at the dose of 6 g/kg/day resulting in the peak blood alcohol concentration (BAC) of 350 mg/dl as assessed on GD 20. Isocaloric intubation and untreated control groups were included. Alcohol exposed rats were not impaired in the rotarod/accelerod tests. Their behavior in the open field and plus maze suggested increased neophobia. Hyperactivity was not observed. In the spatial-navigation task in the water maze, by the middle of the training, fetal alcohol rats showed a tendency towards a slower place acquisition compared to controls, but statistical analysis of the data did not yield between-group differences significant. Towards the end of the training, all rats reached a similar performance level. No detectable between-group differences were noted either in memory retention after a delay, in reversal learning, or in working memory task. Our findings demonstrate that the adverse behavioral effects of a binge-like alcohol administration during half of the first and throughout the second trimester equivalent are difficult to be disclosed in young-adult male Wistar rats. The possible reasons of the lack of significant behavioral deficits in the fetal-alcohol rats observed in the present study are discussed. (c) 2006 Elsevier Inc. All rights reserved.


Effects of prenatal alcohol axplosure on activity, anxiety and learning in young adult Wistar rats
Dursun, İlknur; Doğru, Ewa; Department of Biology (2005)
The objective of the present study was to examine the effects of prenatal exposure to alcohol on sensorimotor coordination, emotionality, learning and memory in young adult Wistar rats. Most of the recent reports concerning behavioral effects of fetal alcohol exposure refer to the juvenile period of life and very few studies investigated different aspects of behavior simultaneously in the same subjects. In the current study, alcohol was delivered to the pregnant dams by intragastric infusions, throughout ge...
Effects of early postnatal alcohol exposure on the developing retinogeniculate projections in C57BL/6 mice
DURSUN, İLKNUR; Jakubowska-Dogru, Ewa; Elibol-Can, Birsen; van der List, Deborah; Chapman, Barbara; Qi, Lihong; Berman, Robert F. (Elsevier BV, 2013-05-01)
Previous studies on the adverse effects of perinatal exposure to ethanol (EtOH) on the developing visual system mainly focused on retinal and optic nerve morphology. The aim of the present study was to investigate whether earlier reported retinal and optic nerve changes are accompanied by anomalies in eye-specific fiber segregation in the dorsal lateral geniculate nucleus (dLGN). C57BL/6 mice pups were exposed to ethanol by intragastric intubation at either 3 or 4 g/kg from postnatal days (PD) 3-10, the thi...
Effects of Early Postnatal Exposure to Ethanol on Retinal Ganglion Cell Morphology and Numbers of Neurons in the Dorsolateral Geniculate in Mice
Dursun, Ilknur; Jakubowska-Dogru, Ewa; van der List, Deborah; Liets, Lauren C.; Coombs, Julie L.; Berman, Robert F. (Wiley, 2011-11-01)
Background: The adverse effects of fetal and early postnatal ethanol intoxication on peripheral organs and the central nervous system are well documented. Ocular defects have also been reported in about 90% of children with fetal alcohol syndrome, including microphthalmia, loss of neurons in the retinal ganglion cell (RGC) layer, optic nerve hypoplasia, and dysmyelination. However, little is known about perinatal ethanol effects on retinal cell morphology. Examination of the potential toxic effects of alcoh...
Effects of Formaldehyde Inhalation on Zinc, Copper and Iron Concentrations in Liver and Kidney of Male Rats
ÖZEN, OĞUZ ASLAN; KUŞ, İLTER; Bakirdere, Sezgin; Sarsilmaz, Mustafa; YAMAN, MEHMET (Springer Science and Business Media LLC, 2011-05-01)
In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body weights in the experimental groups when compared with control groups. It was found that subacute (4-week) or subchronic (13-week) exposure to formaldehyde for rats may cause growth retardation...
Effects of Robotic Rehabilitation on Motor Functions in Children with Cerebral Palsy
Bilgilisoy Filiz, Meral; Toraman, Naciye Füsun; Çiftçi, Can Mehmet Ali; Çakır, Tuncay; Koldaş Doğan, Şebnem; Arslan, Hüseyin (Galenos Yayinevi, 2018-9-1)
Objective: The aim of this study was to investigate the effects of robotic rehabilitation (RR) on spasticity and motor functions of children with varying types and functional levels of cerebral palsy (CP). Materials and Methods: A total of 28 children were evaluated aged 6-16 years, with level 2-4 CP according to the Gross Motor Function Classification System (GMFCS) who were planned to undergo 30 sessions of RR. Motor functions were evaluated before and after RR using the Gross Motor Function scale-6...
Citation Formats
I. Dursun, E. Jakubowska-Dogru, and T. Uzbay, “Effects of prenatal exposure to alcohol on activity, anxiety, motor coordination, and memory in young adult Wistar rats,” PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, pp. 345–355, 2006, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67171.