Fusarium roseum and Aspergillus oryzae-mediated enantioselective reduction of benzils to benzoins

Date

2008-11-01

Author

Elmir, Ayhan S.
Ayhan, Peruze
Demirtas, Umut
Erkilic, Umut

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Aspergillus oryzae OUT5048 and Fusarium roseum OUT4019 were found to be effective biocatalysts in the reduction of benzils to optically active benzoins. Easily available symmetrical benzil derivatives were reduced to the corresponding benzoins [(S)-2-hydroxy-1,2-diphenylethanones] by A. oryzae OUT5048 with tip to 94% ee and by F roseum OUT4019 with up to 98% ee, respectively. In this Work. first general method for whole-cell-mediated selective reduction of benzils to benzoins is reported. It is also shown that this method is applicable for benzils with both electron-withdrawing and electron-donating groups.

Subject Keywords

Process Chemistry and Technology, Biochemistry, Bioengineering, Catalysis

URI

https://hdl.handle.net/11511/67394

Journal

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

DOI

https://doi.org/10.1016/j.molcatb.2008.03.008

Collections

Department of Chemistry, Article

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Citation Formats

A. S. Elmir, P. Ayhan, U. Demirtas, and U. Erkilic, “Fusarium roseum and Aspergillus oryzae-mediated enantioselective reduction of benzils to benzoins,” JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, pp. 164–168, 2008, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67394.