Novel ruthenium(II) and iridium(III) BODIPY dyes: insights into their application in photodynamic therapy in vitro

Date

2019-08-01

Author

Aksakal, Nuray Esra
TANRIVERDİ EÇİK, ESRA
Kazan, Hasan Hueseyin
Ciftci, Goenuel Yenilmez
YÜKSEL, FATMA

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

127
views

0
downloads

Organic-metal complexes are promising molecules for use in photodynamic therapy (PDT). The aim of this study was to investigate in vitro effects of novel Ru(ii) and Ir(iii) BODIPY complexes for PDT. These hybrid organic-metal molecules (Ru-BD and Ir-BD) have been synthesized via reactions of a BODIPY precursor (BD) with a phenanthroline unit bearing Ru(ii) (3) and novel Ir(iii) (4) compounds. The crystal structures of the new distyryl BODIPY (BD) and Ru(ii) complex (3) are also reported. The photophysical and singlet oxygen generation properties of Ru-BD and Ir-BD were investigated in comparison with unsubstituted BODIPY (BD). Moreover, Ru-BD and Ir-BD have been biologically evaluated in vitro in chronic myeloid leukemia and cervical cancer cell lines in terms of photodynamic therapy efficacy in the presence of BD control. These complexes were not toxic in the dark but red light was needed to induce cell death. These data support the fact that Ru-BD could be accepted as a valuable photosensitizer-drug for further PDT treatment.

Subject Keywords

Physical and Theoretical Chemistry

URI

https://hdl.handle.net/11511/67946

Journal

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

DOI

https://doi.org/10.1039/c9pp00201d

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Sol-gel Approaches for Elaboration of Polyol Dehydrogenase-Based Bioelectrodes Urbanova, Veronika; Kohring, Gert-Wieland; Klein, Tobias; Wang, Zhijie; Mert, Olcay; Emrullahoglu, Mustafa; Buran, Kerem; Demir, Ayhan Gürbüz; Etienne, Mathieu; Walcarius, Alain (Walter de Gruyter GmbH, 2013-01-01) This review describes the input of sol-gel chemistry to the immobilization of polyol dehydrogenases on electrodes, for applications in bioelectrocatalysis. The polyol dehydrogenases are described and their application for biosensing, biofuel cell and electrosynthesis are briefly discussed. The immobilization of proteins via sol-gel approaches is described, including a discussion on the difficulty to maintain the activity of proteins in a silica matrix and the strategies developed to offer a proper environme...
The role of antiferromagnetic exchange interactions in dinuclear Cr(III) dithiocarbamates and a stepwise behavior of magnetic moment AYTEKİN, ÖZLEM; Bayri, A. (Pleiades Publishing Ltd, 2012-12-01) In this study the role of the antiferromagnetic interactions in recently synthesized dinuclear Cr(III) complex has been investigated. Since there was not enough structural information for the characterization of the synthesis, we claim that there should be antiferromagnetic interactions between the dinuclear Fe(III) ions, if the proposed structure is the real structure. A new experiment is proposed to test the predictions of this theoretical investigation.
Toward Designed Singlet Fission: Electronic States and Photophysics of 1,3-Diphenylisobenzofuran Schwerin, Andrew F.; Johnson, Justin C.; Smith, Milicent B.; Sreearunothai, Paiboon; Popovic, Duska; Cerny, Jiri; Havlas, Zdenek; Paci, Irina; Akdağ, Akın; MacLeod, Matthew K.; Chen, Xudong; David, Donald E.; Ratner, Mark A.; Miller, John R.; Nozik, Arthur J.; Michl, Josef (American Chemical Society (ACS), 2010-01-01) Single crystal molecular structure and solution photophysical properties are reported for 1,3-diphenylisobenzofuran (1), of interest its a model compound in studies of singlet fission. For the ground state of I and of its radical cation (1(+center dot)) and anion (1(-center dot)), we report the UV-visible absorption spectra, and for neutral 1, also the magnetic circular dichroism (MCD) and the decomposition of the absorption spectrum into purely polarized components, deduced from fluorescence polarization. ...
Development of the ReaxFF Reactive Force Field for Inherent Point Defects in the Si/Silica System Nayir, Nadire; van Duin, Adri C. T.; Erkoç, Şakir (American Chemical Society (ACS), 2019-05-16) We redeveloped the ReaxFF force field parameters for Si/O/H interactions that enable molecular dynamics (MD) simulations of Si/SiO2 interfaces and O diffusion in bulk Si at high temperatures, in particular with respect to point defect stability and migration. Our calculations show that the new force field framework (ReaxFF(present)), which was guided by the extensive quantum mechanical-based training set, describes correctly the underlying mechanism of the O-migration in Si network, namely, the diffusion of...
A novel one-pot synthesis of ferrocenyl-substituted 1,2,4-oxadiazoles Zora, Metin; Kelgokmen, YILMAZ (Elsevier BV, 2014-06-01) One-pot synthesis of 5-ferrocenyl-1,2,4-oxadiazoles via the reaction between 3-ferrocenylpropynal and amidoximes is described. 3-Ferrocenylpropynal reacts with a variety of amidoximes in the presence of KOH in refluxing dioxane to afford a broad range of 5-ferrocenyl-1,2,4-oxadiazole derivatives. The reaction first produces the corresponding conjugate addition product which, upon cyclization and rearrangement, yields the targeted 1,2,4-oxadiazole. The reaction appears to be general for a diversity of amidox...

Citation Formats

N. E. Aksakal, E. TANRIVERDİ EÇİK, H. H. Kazan, G. Y. Ciftci, and F. YÜKSEL, “Novel ruthenium(II) and iridium(III) BODIPY dyes: insights into their application in photodynamic therapy in vitro,” PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, pp. 2012–2022, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67946.