Effect of medication on biomechanical properties of rabbit bones: Heparin induced osteoporosis

Akkas, N
Yeni, YN
Turan, B
Delilbasi, E
Gunel, U
The aim of this controlled study is to investigate the effect of heparin on osteoporosis initiation and of calcitonin and tamoxifen on the progress of osteoporosis induced by heparin through biomechanical means and, thus, to assist in clinical usage of these drugs, 32 four-month-old female New Zealand white rabbits were divided into four different experimental groups, The animals in group A were administered heparin (Liquemine) intraperitoneally at the dosage of 1000 IU/kg/day, The animals in group B were injected the same amount of heparin as those of group A, and in addition, were given calcitonin at the dosage of 100 IU/kg/day, The animals in group C were medicated the same way as group B but 2 mg/kg/day tamoxifen (Nolvadex) was orally added into their intestine via cannula, one side connected to the injector, The animals in group D were the control, The experiment lasted 8 weeks, The animals in all experimental groups showed the same growth pattern as that of the control group, Whole-bone femur, humerus and tibia specimens were subjected to 3-point bending tests while sections from the proximal ends of the same specimens were subjected to compression tests, The data, recorded as load vs deflection, were converted into stress vs strain using the strength of materials formulae, The data obtained from the bending and the compression experiments were treated separately The stiffness of the bones of the medicated groups were compared with those of the control groups, Our data indicated that the tamoxifen treated humera, femora and tibiae attained the largest bending stiffness in all cases investigated, However, this was not the case for compression, None of the drug administered groups attained the stiffness of the control group except for the case of tamoxifen treated femora which attained stiffness close to that of the controls, The results show that heparin altered the mechanical properties of bones indicating osteoporosis, tamoxifen was effective in reducing the effect of heparin while calcitonin yielded no conclusive result.


Effect of dietary selenium and vitamin E on the biomechanical properties of rabbit bones
Turan, B; Balcik, C; Akkas, N (Springer Science and Business Media LLC, 1997-09-01)
It is generally agreed that combined deficiency of selenium and vitamin E leads to several abnormalities including Kashin-Beck disease which is an endemic and chronic degenerative osteoarthrosis. The abnormalities can be reversed by the administration of various forms of selenium and vitamin E.
Effects of selenium supplementation on rat heart apex and right ventricle myocardia by using FTIR spectroscopy: A cluster analysis and neural network approach
TOYRAN AL OTAİBİ, NESLİHAN; Severcan, Feride; Severcan, Mete; TURAN, Belma (Elsevier BV, 2008-10-01)
The effects of selenium supplementation on apex and right ventricle myocardia of the rat heart were investigated using Fourier transform infrared (FTIR) spectroscopy by examining the changes in the frequency values of major absorptions arising from lipids and proteins. Cluster analysis was used to discriminate the selenium treated group from the control by utilizing two distinct spectral regions, belonging to absorptions arising from lipids and proteins, respectively. In addition, protein secondary structur...
The expression of GST isoenzymes and p53 in non-small cell lung cancer.
Oguztßzun, Serpil; Aydin, Mehtap; Demirag, Funda; Yazici, Ulkß; Ozhavzali, Mßzeyyen; Kiliç, Murat; Can, Mesude IŠ(VM Media SP. zo.o VM Group SK, 2010-6-10)
This study investigated the immunohistochemical staining characteristics of glutathione-S-transferase alpha, pi, mu, theta and p53 in non-small cell lung carcinoma and normal lung tissue from 50 patients. The relationships between expressions of the Glutathione-S-transferase isoenzymes and some clinicopathological features were also examined. Expression of glutathione-S-transferase pi, mu, alpha, theta and p53 was assessed by immunohistochemistry for primary lung carcinomas of 50 patients from the Sanitariu...
Biomechanical Analysis of the Effect of Mesenchymal Stem Cells on Mandibular Distraction Osteogenesis
Aykan, Andac; Ozturk, Serdar; Sahin, Ismail; Gürses, Senih; Ural, Ali Ugur; Oren, Nisa Cem; Isik, Selcuk (Ovid Technologies (Wolters Kluwer Health), 2013-03-01)
Background: The purpose of this study was to investigate the effects of bone marrow-derived stem cells on consolidation period by using a new biomechanical testing method on sheep mandible model.
Effects of custom made insole on gait pattern of patients with unilateral displaced intra articular calcaneal fracture evaluation with computerized gait analysis
ÖÇGÜDER, Ali; GÖK, HAYDAR; HEYCAN, Cengiz; O, TECİMEL; Tönük, Ergin; BOZKURT, MURAT (AVES Publishing Co., 2012-01-01)
Objective: The aim of this study was to investigate whether use of custom-fabricated insoles improves the gait pattern in patients with displaced intra-articular calcaneal fractures. Methods: Fourteen patients (7 female, 7 male; mean age: 39±12 years) and 11 healthy individuals (mean age: 42±13 years) were included in the study. Treatment protocol included conservative treatment involving immobilization, with or without closed reduction, active exercises, wear of a customfabricated insole and prospective fo...
Citation Formats
N. Akkas, Y. Yeni, B. Turan, E. Delilbasi, and U. Gunel, “Effect of medication on biomechanical properties of rabbit bones: Heparin induced osteoporosis,” CLINICAL RHEUMATOLOGY, pp. 585–595, 1997, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67950.