The Effects of Chloramphenicol on Some Biochemical Parameters in Mice

Date

2008-12-01

Author

Ege, Hismiogullari Sahver
Tunay, Kontas
Adil, Hismiogullari Adnan
Dinc, Essiz
Gokhan, Eraslan

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

144
views

0
downloads

The aim of the study was to investigate the effects of some dose regimens of chloramphenicol on some biochemical parameters in mice for acute and subacute periods. Chloramphenicol was given to the experimental groups at the doses of 100 mg kg(-1) bw (group 2) and 200 mg kg(-1) bw (group 3) in drinking water for 7 days. Blood samples were taken from all animals on day 0, 1, 7 and 14 of the study. The hepatotoxic effect of cloramphenicol occurred in groups 2 and 3 with increasing doses of cloramphenicol. Hepatotoxicity in groups 2 and 3 was determined based on the levels of increased activity of ALP, AST and ALT.

Subject Keywords

Chloramphenicol, Mice, Hepatotoxity, Antibiotic, Biochemical parameters

URI

https://hdl.handle.net/11511/68201

Journal

JOURNAL OF ANIMAL AND VETERINARY ADVANCES

Collections

Unclassified, Article

Suggestions

OpenMETU
Core

The effect of arginine-428 mutation on modulation of activity of human liver flavin monooxygenase 3 (FMO3) by imipramine and chlorpromazine Adalı, Orhan; Philpot, RM (1999-07-01) This study was carried out to investigate the molecular basis for modulation of recombinant FMO3-catalyzed activity by the tricyclicantidepressants, imipramine and chlorpromazine. A mutant of human liver FMO3 (T428R) was formed by site-directed mutagenesis and characterized along with the native enzyme in order to elucidate a possible structure-function relationship. Functional properties of native and T428R human FMO3s were studied with methimazole as substrate. Both enzymes catalyzed the S-oxidation of me...
The effects of local and sustained release of fibroblast growth factor on testicular blood flow and morphology in spermatic artery- and vein-ligated rats Guler, F; Bingol-Kologlu, MB; Yagmurlu, A; Guven, C; Hasırcı, Nesrin; Kucuk, O; Aytac, S; Dindar, H (2004-05-01) Background/Purpose: This study was carried out to evaluate the effects of local and sustained release of fibroblast growth factor (FGF) on testicular blood flow and morphology in spermatic artery- and vein-ligated rats.
In vivo half life of nanoencapsulated L-asparaginase Baran, ET; Ozer, N; Hasırcı, Vasıf Nejat (2002-12-01) In the present study, antileukemic enzyme L-asparaginase (ASNase) was encapsulated into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocapsules in order to decrease the immunogenicity and toxicity of the enzyme and to increase its in vivo half life in mice.
The structural effects of Vitamin A deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics ELİBOL, BİRSEN; Severcan, Mete; Jakubowska-Dogru, Ewa; DURSUN, İLKNUR; Severcan, Feride (2022-04-01) The structural effects of vitamin A-deficiency were examined on the molecular profiles of biomolecules of male rat hippocampus during prolonged ethanol intake/withdrawal using FT-IR spectroscopy coupled with chemometrics. Liquid ethanol diet with/without vitamin A was maintained to adult rats for 3-months. The rats were decapitated at different ethanol withdrawal times and FT-IR spectra were obtained. Ethanol consumption/withdrawal produced significant changes in proteins' conformations, while having insign...
The inhibitory effects of lindane in batch and upflow anaerobic sludge blanket reactors Bayramoğlu, Tuba Hande; Demirer, Göksel Niyazi (Elsevier BV, 2003-01-01) In this study, the inhibitory effects of lindane (LIN) on originally unacclimated mixed anaerobic cultures were investigated by anaerobic toxicity assay (ATA) experiments. ATA experiments revealed that 10 mg/l LIN exerted inhibitory effects on anaerobic cultures, which was recoverable. Continuous reactor experiments conducted to determine the inhibitory effects of LIN and the maximum LIN loading rate achievable in two-stage upflow anaerobic sludge blanket (UASB) reactors indicated that anaerobic granular cu...

Citation Formats

H. S. Ege, K. Tunay, H. A. Adil, E. Dinc, and E. Gokhan, “The Effects of Chloramphenicol on Some Biochemical Parameters in Mice,” JOURNAL OF ANIMAL AND VETERINARY ADVANCES, pp. 1579–1582, 2008, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68201.