Magnesium doping on TiN coatings affects mesenchymal stem cell differentiation and proliferation positively in a dose-dependent manner

ÖNDER, Sakip
Calikoglu-Koyuncu, Ayse Ceren
Kazmanli, Kursat
Urgen, Mustafa
Kök, Fatma Neşe
BACKGROUND: In vitro evaluation of cell-surface interactions for hard tissue implants have mostly been done using osteoblasts. However, when an implant is placed in the body, mesenchymal stem cells (MSCs) play a major role in new bone formation. Therefore, using MSCs in cell-surface investigations may provide more reliable information on the prediction of in vivo behavior of implants.


Poly( amino acid)-based fibrous scaffolds modified with surface-pendant peptides for cartilage tissue engineering
Svobodova, Jana; Proks, Vladimir; Karabiyik, Ozge; Koyuncu, Ayse Ceren Calikoglu; Kose, Gamze Torun; Rypacek, Frantisek; Studenovska, Hana (Wiley, 2017-03-01)
In this study, fibrous scaffolds based on poly(gamma-benzyl-L-glutamate) (PBLG) were investigated in terms of the chondrogenic differentiation potential of human tooth germ stem cells (HTGSCs). Through the solution-assisted bonding of the fibres, fully connected scaffolds with pore sizes in the range 20-400 mu m were prepared. Biomimetic modification of the PBLG scaffolds was achieved by a two-step reaction procedure: first, aminolysis of the PBLG fibres' surface layers was performed, which resulted in an i...
Numerical simulation of the effect of time-to-loading on peri-implant bone
AKÇA, KIVANÇ; Eer, Atilim; Canay, Senay (Elsevier BV, 2010-01-01)
Purpose: To evaluate the effect of time-to-loading on trabecular bone around single-tooth dental implants using numerical solutions based on computer models.
Resorbable PCEC/gelatin-bismuth doped bioglass-graphene oxide bilayer membranes for guided bone regeneration
Pazarçeviren, Ahmet Engin; Evis, Zafer; Keskin, Dilek; Tezcaner, Ayşen (IOP Publishing, 2019-05-01)
Guided bone regeneration (GBR) is a therapeutic modality applied prior to dental implant placement to increase bone density at the defect site or during placement for directing bone growth around implant. In this study, an asymmetric, bilayer structure was prepared by covalently bonding a dense polycaprolactone-polyethylene glycol-polycaprolactone (PCEC) membrane layer with a hydrogel layer composed of bismuth doped bioactive glass (BG, 45S5) and graphene oxide (GO) particles incorporated in gelatin. Struct...
Native extracellular matrix/fibroin hydrogels for adipose tissue engineering with enhanced vascularization
Kayabolen, Alisan; Keskin, Dilek; Aykan, Andac; Karslioglu, Yildirim; Zor, Fatih; Tezcaner, Ayşen (IOP Publishing, 2017-06-23)
Adipose tissue engineering is a promising field for regeneration of soft tissue defects. However, vascularization is needed since nutrients and oxygen cannot reach cells in thick implants by diffusion. Obtaining a biocompatible scaffold with good mechanical properties is another problem. In this study, we aimed to develop thick and vascularized adipose tissue constructs supporting cell viability and adipose tissue regeneration. Hydrogels were prepared by mixing rat decellularized adipose tissue (DAT) and si...
Composite clinoptilolite/PCL-PEG-PCL scaffolds for bone regeneration: In vitro and in vivo evaluation
Pazarçeviren, Ahmet Engin; Altunbas, Korhan; Yaprakci, Volkan; Erdemli, Ozge; Keskin, Dilek; Tezcaner, Ayşen (Wiley, 2020-01-01)
In this study, clinoptilolite (CLN) was employed as a reinforcement in a polymer-based composite scaffold in bone tissue engineering and evaluated in vivo for the first time. Highly porous, mechanically stable, and osteogenic CLN/PCL-PEG-PCL (CLN/PCEC) scaffolds were fabricated with modified particulate leaching/compression molding technique with varying CLN contents. We hypothesized that CLN reinforcement in a composite scaffold will improve bone regeneration and promote repair. Therefore, the scaffolds we...
Citation Formats
S. ÖNDER, A. C. Calikoglu-Koyuncu, K. Kazmanli, M. Urgen, F. N. Kök, and G. KÖSE, “Magnesium doping on TiN coatings affects mesenchymal stem cell differentiation and proliferation positively in a dose-dependent manner,” BIO-MEDICAL MATERIALS AND ENGINEERING, pp. 427–438, 2018, Accessed: 00, 2020. [Online]. Available: