Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model Laboratory investigation

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2009-12-01

Author

Cemil, Berker
Tun, Kagan
Kaptanoglu, Erkan
Kaymaz, Figen
Cevirgen, Banu
CÖMERT, AYHAN
TEKDEMİR, İBRAHİM

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Object. Epidural fibrosis is the scar tissue formed over the dura mater after a laminectomy. Extensive epidural fibrosis may be an important underlying cause of failed back syndrome. Pimecrolimus, an ascomycin derivative, is one of the new classes of immunomodulating macrolactams and was specifically developed for the treatment of inflammatory diseases. This study examined the preventive effects of the local application of pimecrolimus in minimizing spinal epidural fibrosis in a rat laminectomy model.

Subject Keywords

General Medicine

URI

https://hdl.handle.net/11511/68414

Journal

JOURNAL OF NEUROSURGERY-SPINE

DOI

https://doi.org/10.3171/2009.6.spine08580

Collections

Department of Statistics, Article

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Citation Formats

B. Cemil et al., “Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model Laboratory investigation,” JOURNAL OF NEUROSURGERY-SPINE, pp. 758–763, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68414.