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Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model Laboratory investigation
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Date
2009-12-01
Author
Cemil, Berker
Tun, Kagan
Kaptanoglu, Erkan
Kaymaz, Figen
Cevirgen, Banu
CÖMERT, AYHAN
TEKDEMİR, İBRAHİM
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Object. Epidural fibrosis is the scar tissue formed over the dura mater after a laminectomy. Extensive epidural fibrosis may be an important underlying cause of failed back syndrome. Pimecrolimus, an ascomycin derivative, is one of the new classes of immunomodulating macrolactams and was specifically developed for the treatment of inflammatory diseases. This study examined the preventive effects of the local application of pimecrolimus in minimizing spinal epidural fibrosis in a rat laminectomy model.
Subject Keywords
General Medicine
URI
https://hdl.handle.net/11511/68414
Journal
JOURNAL OF NEUROSURGERY-SPINE
DOI
https://doi.org/10.3171/2009.6.spine08580
Collections
Department of Statistics, Article