The effect of mitomycin C as fibrosis preventive agent during craniectomies

Date

2009-01-01

Author

Cemil, Berker
Tun, Kagan
Kaptanoglu, Erkan
Cevirgen, Banu
Gurcay, Ahmet Gurhan
Kaymaz, Figen
TEKDEMİR, İBRAHİM

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Object. The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy. Methods. Craniectomies were performed in the right frontoparietal region; after the procedure the animals had been divided in 2 groups of 10 each. Cotton pads soaked with 0.1mg/ml MMC or saline (control) were applied to the operative sites. Four weeks after craniectomy the rats were sacrificed, and epidural fibrosis was evaluated histologically. The dura mater thickness, the density of epidural fibrosis, arachnoidal involvement, and bone regeneration were determined. Results. No obvious adhesion formed in the rats in the MMC group, but severe epidural adhesions were found in control group. The duramater thickness, the density of epidural fibrosis, and arachnoidal involved rat number in the MMC group were significantly lower than in control groups. Conclusions. Epidural fibrosis can be a devastating condition that forms after craniectomy. Topical application of mitomycin C may be a successful method of preventing epidural fibrosis following craniectomy.

Subject Keywords

Surgery, Clinical Neurology, General Medicine

URI

https://hdl.handle.net/11511/68447

Journal

BRITISH JOURNAL OF NEUROSURGERY

DOI

https://doi.org/10.1080/02688690802603913

Collections

Department of Statistics, Article

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Citation Formats

B. Cemil et al., “The effect of mitomycin C as fibrosis preventive agent during craniectomies,” BRITISH JOURNAL OF NEUROSURGERY, pp. 304–308, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68447.