The effect of mitomycin C as fibrosis preventive agent during craniectomies

Cemil, Berker
Tun, Kagan
Kaptanoglu, Erkan
Cevirgen, Banu
Gurcay, Ahmet Gurhan
Kaymaz, Figen
Object. The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy. Methods. Craniectomies were performed in the right frontoparietal region; after the procedure the animals had been divided in 2 groups of 10 each. Cotton pads soaked with 0.1mg/ml MMC or saline (control) were applied to the operative sites. Four weeks after craniectomy the rats were sacrificed, and epidural fibrosis was evaluated histologically. The dura mater thickness, the density of epidural fibrosis, arachnoidal involvement, and bone regeneration were determined. Results. No obvious adhesion formed in the rats in the MMC group, but severe epidural adhesions were found in control group. The duramater thickness, the density of epidural fibrosis, and arachnoidal involved rat number in the MMC group were significantly lower than in control groups. Conclusions. Epidural fibrosis can be a devastating condition that forms after craniectomy. Topical application of mitomycin C may be a successful method of preventing epidural fibrosis following craniectomy.


Use of pimecrolimus to prevent epidural fibrosis in a postlaminectomy rat model Laboratory investigation
Cemil, Berker; Tun, Kagan; Kaptanoglu, Erkan; Kaymaz, Figen; Cevirgen, Banu; CÖMERT, AYHAN; TEKDEMİR, İBRAHİM (Journal of Neurosurgery Publishing Group (JNSPG), 2009-12-01)
Object. Epidural fibrosis is the scar tissue formed over the dura mater after a laminectomy. Extensive epidural fibrosis may be an important underlying cause of failed back syndrome. Pimecrolimus, an ascomycin derivative, is one of the new classes of immunomodulating macrolactams and was specifically developed for the treatment of inflammatory diseases. This study examined the preventive effects of the local application of pimecrolimus in minimizing spinal epidural fibrosis in a rat laminectomy model.
Use of the dynamic volume spline method to predict facial soft tissue changes associated with orthognathic surgery
Ulusoy, İlkay; Sabuncuoglu, Fidan; GÖRGÜLÜ, SERKAN; ÜÇOK, CEMİLE ÖZLEM (Elsevier BV, 2010-11-01)
Objective. The shape of the face can be estimated before the surgery by using 3-dimensional computer programs that provide tools to guide skill modifications. The aim of this study was to present the dynamic volume spline method to predict facial soft tissue changes after the modification of the skull associated with orthognathic surgery.
Effects of pretreated beet molasses on benzaldehyde lyase production by recombinant Escherichia coli BL21(DE3)pLySs
Çalık, Pınar (Wiley, 2009-11-01)
Effects of microwave and ultrasonic extraction methods on total phenolic content of nettle (Urtica diocia)
Ince, Alev Emine; Şahin, Serpil; Sumnu, Gulum (null; 2011-12-01)
Abstract. Effects of different extraction methods at different conditions on total phenolic content (TPC) of nettle (Urtica diocia) were investigated. Water was used as solvent. TPC analysis was performed according to Folin-Ciocalteu method. In microwave extraction, heating was achieved using microwaves at 407W power level. Effects was obtained as 1:30 solid-to-solvent ratio for 10min. Extraction was also performed conventionally at 1:30 solid-to-solvent ratio for 30min for comparison. There was no signific...
The association between adenomyosis and recurrent miscarriage
Atabekoğlu, Cem Somer; Şükür, Yavuz Emre; Kalafat, Erkan; Özmen, Batuhan; Berker, Bülent; Aytac, Rusen; Sönmezer, Murat (2020-07-01)
Objective(s) To assess the association between the ultrasonographic presence of adenomyosis and recurrent miscarriage (RM). Study Design A prospective matched case-control study was conducted between March 2018 and December 2018 at Ankara University Hospital. A total of 132 women were assessed with transvaginal ultrasonography for the presence of adenomyosis markers. The case group consisted of 66 women with RM. The control group consisted of 66 women without RM or any other gynaecologic conditions. The ra...
Citation Formats
B. Cemil et al., “The effect of mitomycin C as fibrosis preventive agent during craniectomies,” BRITISH JOURNAL OF NEUROSURGERY, pp. 304–308, 2009, Accessed: 00, 2020. [Online]. Available: