EVALUATION OF ANTIBACTERIAL AND CARBONIC ANHYDRASE INHIBITORY POTENTIAL OF METHANOLIC EXTRACT OF &ITNARDOSTACHYS JATAMANSI&IT (D. DON) DC RHIZOMES

Date

2017-09-01

Author

Rehman, Tayyeba
Ahmad, Saeed
Abbasi, Waheed Mumtaz
Ahmad, Ashfaq
Bilal, Muhammad
Zaman, Muhammad Mohsin
Ghauri, Aymen Owais
Arshad, Adeel
Akhtar, Khalid

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

216
views

0
downloads

Many antimicrobial drugs are going to become resistant to different pathogens, so the discovery of new antimicrobial products is an important public health concern. Nardostachys jatamansi (D. Don) DC (Valerianaceae) is an important traditional herbal medicine used as tranquillizer. CNS sedative. antiepilepsy, cardiotonic. diuretic, heptatonic, analgesic and in boils, itch and eye diseases. Carbonic anhydrase inhibitors are the potential source of treatment in case of glaucoma, hypertension and epilepsy and also used as diuretics. The aim of present study was to evaluate the antibacterial activity of methanolic extract of N. jatamansi against different bacterial strains and to estimate its carbonic anhydrase inhibitory potential. Antibacterial activity was evaluated by agar well diffusion assay and broth microdilution assay. The study revealed that N. jatamansi extract is sensitive to all tested bacterial strains. The zones of inhibition and MIC ranged from 8-22 at a concentration of 1-5 mg/mL and 0.3-0.6 mg/mL. respectively. Methanolic extract of N. jatamansi showed marked inhibition of carbonic anhydrase (IC 50 712.41 +/- 0.001 mu g/mL) when compared with standard acetazolamide. The results of the study suggest that N. jatamansi may be a valuable plant source of medicinally useful active compounds that can be helpful in bacterial infections and showed some relation with the traditional use of this plant in various diseases.

Subject Keywords

Nardostachys jatamansi, Antibacterial, Carbonic anhydrase inhibitor

URI

https://hdl.handle.net/11511/68524

Journal

ACTA POLONIAE PHARMACEUTICA

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Determination of colistin resistance in Escherichia coli isolates from foods in Turkey, 2011-2015 Güzel, Mustafa; Avşaroğlu, M Dilek; Soyer, Yeşim (2020-05-01) Antimicrobial resistance of pathogenic microorganisms is an emerging public health concern. Intensive use of antibiotics in food animals might increase antimicrobial resistance in foodborne pathogens. Colistin is a last resort antibiotic for treatment of multidrug resistant (MDR) Gram negative pathogens. The recent antimicrobial resistance studies revealed a mobile antimicrobial resistance gene (mcr) that provides resistance to colistin. Furthermore, the gene has been found in different genera. Therefore, t...
Development and analysis of controlled release polymeric rods containing vancomycin Tağıt, Oya; Hasırcı, Vasıf Nejat; Department of Biotechnology (2005) Antibiotic use is a vital method for the treatment of most diseases involving bacterial infections. Unfortunately, in certain cases these agents are not effective in treatments against diseases for either some limitation in antibiotic usage because of the side effects or some distribution problems caused by physiological or pathological barriers in the body. Such problems are thought to be minimized by development of controlled release systems which involve implantation of antibiotic loaded polymeric system...
Determination of phenolic compound profiles and antioxidant effect of black elderberry, echinacea and iceland moss extracts on late-release soft lozenge Yıldız, Özge; Bayındırlı, Alev; Çapanoğlu Güven, Esra; Department of Food Engineering (2021-6) Medicinal plants contain different bioactive compounds that have immune system stimulant, anti-inflammatory, antibacterial, antiviral, antifungal, anticancer and wound healing effects. Echinacea purpurea L., Sambucus nigra L. and Cetraria islandica L. are known with their high antioxidant content and health promoting properties. The main objective of the study was to determine the total phenolic content, total flavonoid content and antioxidant capacity of each plant extract with water and 75 % ethanol as so...
Design and characterization of capsaicin loaded nanoemulsions Akbaş, Elif; Öztop, Halil Mecit; Söyler, Ulviye Betül; Department of Food Engineering (2016) In recent years, nanoemulsion based systems have been successfully used in food, medical and pharmaceutical applications as effective lipophilic carrier systems for nutraceuticals, drugs, antioxidants and antimicrobial agents. The primary active ingredient of chili pepper, capsaicin is a hydrophobic substance and was proved to be a compound showing good antimicrobial activity against various microorganisms. The aim of the proposed study was to prepare and characterize capsaicin loaded nanoemulsion systems. ...
Investigations on the properties and drug releases of biodegradable polymer coatings on metal substrates as drug carriers Baydemir, Tuncay; Bayramlı, Erdal; Department of Polymer Science and Technology (2009) The use of various biodegradable polymers for the improvement of different controlled and long-lasting drug release systems is an active research area in recent years. The application of different metal prostheses, especially titanium based ones, to the human body is also very common. A most important disadvantage of these prostheses is the risk of infection at the application areas that necessitates the removing of the prosthesis with a second surgical operation and reapplication of it after recovery. One ...

Citation Formats

T. Rehman et al., “EVALUATION OF ANTIBACTERIAL AND CARBONIC ANHYDRASE INHIBITORY POTENTIAL OF METHANOLIC EXTRACT OF &ITNARDOSTACHYS JATAMANSI&IT (D. DON) DC RHIZOMES,” ACTA POLONIAE PHARMACEUTICA, pp. 1471–1476, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68524.