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Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment
Date
2013-06-01
Author
Özçelikkale, Altuğ
Han, Bumsoo
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Nanomedicine for cancer, where nanoparticles (NPs) are used to deliver drugs, imaging agents, and heat to tumors, shows great potential of improved therapeutic outcomes. In spite of promising early stage results, its clinical efficacy is still significantly limited due to complex transport barriers in vivo. These transport barriers are associated with tumor microenvironment, which is highly complex and heterogeneous and varies spatiotemporally. Thus, in order to improve the in vivo efficacy of nanomedicine, NPs need to be designed and characterized considering their interaction with these complex transport barriers. In this article, thus, we discuss the multifaceted transport characteristics of NPs and their interaction mechanisms with the tumor microenvironment. We also illustrated that NPs have highly spatiotemporal and multiscale distribution around tumor. This dynamic and complex nature of NP transport needs to be taken into consideration in design strategies and evaluation criteria for successful delivery of cancer nanomedicine.
Subject Keywords
Molecular Medicine
,
Drug Discovery
,
Pharmaceutical Science
URI
https://hdl.handle.net/11511/69373
Journal
MOLECULAR PHARMACEUTICS
DOI
https://doi.org/10.1021/mp3005947
Collections
Department of Mechanical Engineering, Article
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A. Özçelikkale and B. Han, “Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment,”
MOLECULAR PHARMACEUTICS
, pp. 2111–2126, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/69373.