Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment

Date

2013-06-01

Author

Özçelikkale, Altuğ
Han, Bumsoo

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

132
views

0
downloads

Nanomedicine for cancer, where nanoparticles (NPs) are used to deliver drugs, imaging agents, and heat to tumors, shows great potential of improved therapeutic outcomes. In spite of promising early stage results, its clinical efficacy is still significantly limited due to complex transport barriers in vivo. These transport barriers are associated with tumor microenvironment, which is highly complex and heterogeneous and varies spatiotemporally. Thus, in order to improve the in vivo efficacy of nanomedicine, NPs need to be designed and characterized considering their interaction with these complex transport barriers. In this article, thus, we discuss the multifaceted transport characteristics of NPs and their interaction mechanisms with the tumor microenvironment. We also illustrated that NPs have highly spatiotemporal and multiscale distribution around tumor. This dynamic and complex nature of NP transport needs to be taken into consideration in design strategies and evaluation criteria for successful delivery of cancer nanomedicine.

Subject Keywords

Molecular Medicine, Drug Discovery, Pharmaceutical Science

URI

https://hdl.handle.net/11511/69373

Journal

MOLECULAR PHARMACEUTICS

DOI

https://doi.org/10.1021/mp3005947

Collections

Department of Mechanical Engineering, Article

Suggestions

OpenMETU
Core

Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model Özçelikkale, Altuğ; Noe-Kim, Victoria; Elzey, Bennett D.; Dong, Zizheng; Zhang, Jian-Ting; Kim, Kwangmeyung; Kwon, Ick Chan; Park, Kinam; Han, Bumsoo (Elsevier BV, 2017-11-01) Successful drug delivery and overcoming drug resistance are the primary clinical challenges for management and treatment of cancer. The ability to rapidly screen drugs and delivery systems within physiologically relevant environments is critically important; yet is currently limited due to lack of appropriate tumor models. To address this problem, we developed the Tumor-microenvironment-on-chip (T-MOC), a new microfluidic tumor model simulating the interstitial flow, plasma clearance, and transport of the d...
Dual-adjuvant effect of pH-sensitive liposomes loaded with STING and TLR9 agonists regress tumor development by enhancing Th1 immune response Kocabas, Banu Bayyurt; Almacioglu, Kubra; Bulut, Esin Alpdundar; Gucluler, Gozde; Tincer, Gizem; Bayik, Defne; Gürsel, Mayda; GÜRSEL, İHSAN (Elsevier BV, 2020-12-01) Nucleic acid-based pattern recognition receptor agonists are effective adjuvants and immunotherapeutic agents. Rather than single applications, ligand combinations could synergistically potentiate immune responses by elevating cytokine and chemokine production via triggering multiple signaling pathways. However, short half-lives of such labile ligands due to nuclease attack and limited cellular uptake due to their structure significantly hamper their in vivo performances. More importantly, simultaneous deli...
Investigation of in vitro cytotoxic effects of heparin coated iron oxide nanoparticles combined with tpp-dca on human hepatocellular carcinoma cell line HEPG2 Saraç, Başak Ezgi; Güray, Nülüfer Tülün; Volkan, Mürvet; Department of Biology (2018) Nanotechnology in medicine involves the applications of nanoparticles and one of the rising field is cancer nanotechnology, which has been increasingly used in cancer diagnostics, imaging, and therapeutic drug delivery. The advantage of the use of the nanoparticles is that, they can be designed to be specific for tumor tissue. This allows increased drug delivery efficiency and reduced off-target toxicities. Iron oxide nanoparticles used in this study are smaller than 100 nm but still it gives an enhanced su...
Comparison of trace metal concentrations in malign and benign human prostate Yaman, Mehmet; Atici, Demet; Bakirdere, Sezgin; Akdeniz, Ismail (American Chemical Society (ACS), 2005-01-27) Imbalance in the composition of trace metals, recognized to be essential to normal human homeostasis, besides the accumulation of potentially toxic or nonessential trace metals, may cause disease. Thus, there is a need for their analysis in cancerous and noncancerous human tissues to examine the relationship between cancer and these elements. Trace metal concentrations including Cd, Ni, Zn, Cu, Fe, Mg, and Ca in both malign and benign prostate samples were determined by atomic absorption spectrophotometry. ...
Targeted delivery of CPG-oligodeoxynucleotide to breast cancer cells by poly-amidoamine dendrimer-modified magnetic nanoparticles Taghavi Pourianazar, Negar; Gündüz, Ufuk; Gündüz, Güngör; Department of Biotechnology (2016) One major application of nanotechnology in cancer treatment involves designing nanoparticles to deliver drugs, oligonucleotides, and genes to cancer cells. Nanoparticles should be engineered so that they could target and destroy tumor cells with minimal damage to healthy tissues. This research aims to develop an appropriate and efficient nanocarrier, having the ability of interacting with and delivering CpG-oligodeoxynucleotides (CpG-ODNs) to tumor cells. CpG-ODNs activate Toll-like receptor 9 (TLR9), which...

Citation Formats

A. Özçelikkale and B. Han, “Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment,” MOLECULAR PHARMACEUTICS, pp. 2111–2126, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/69373.