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Gelatin sponges as wound dressing materials
Date
2000
Author
Aksu, Ebru
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https://hdl.handle.net/11511/7630
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Graduate School of Natural and Applied Sciences, Thesis
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Gelatin microspheres and gelatin sponges were prepared by coacervation and freeze drying techniques, respectively. Both systems were crosslinked with glutaraldehyde. The mean diameter of the microspheres were in the range of 40-80 mum and the mean pore size of the sponges was 130-220 mum depending on the preparation conditions. Bovine serum albumin (BSA) was added into the preparation solutions and entrapped in the microspheres and sponges. BSA addition to sponges was also achieved by addition of BSA-contai...
Gelatin Based Scaffolds and Effect of EGF Dose on Wound Healing
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In this study, gelatin based biodegradable scaffolds (GS) containing various amounts of epidermal growth factor (EGF) were prepared and applied to full skin defects created on rats in order to investigate the EGF dose effect on healing process. Scaffolds were prepared by freeze drying technique and stabilized with either glutaraldehyde (GA) or 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC). In vitro cytotoxicity of the prepared scaffolds was assessed by using human skin fibroblast secondary culture (...
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E. Aksu, “Gelatin sponges as wound dressing materials,” Middle East Technical University, 2000.