Hydrogels as a New Platform to Recapitulate the Tumor Microenvironment

Date

2018-01-01

Author

Ermiş Şen, Menekşe
Çalıbaşı, Gizem
Güven, Sinan
Durmuş, Naşide Gözde
Rizvi, Imran
Hasan, Tayyaba
Hasırcı, Nesrin
Hasırcı, Vasıf Nejat

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Recent advances in tissue engineering include the incorporation of multiple cell types into three-dimensional (3D) hydrogels to recapitulate extracellular matrix (ECM) structures and the functionality of living tissues in vitro. For decades, researchers have been investigating the complex mechanisms of cancer metastasis, tumorigenesis, and angiogenesis over two-dimensional (2D) monolayer cell culture models, or in vivo animal models. Increasing numbers of unsuccessful clinical trials for cancer therapy indicate the need to upgrade the current practice in the culturing of cancer cells and modeling of tumor microenvironments in vitro. The use of new 3D hydrogels as a new platform that can recapture many crucial features of the native tumor microenvironment would be advantageous in the assessment of cancer progression and metastasis for clinical trials.

Subject Keywords

Hydrogels, Cancer microenvironment, Cancer model, Microfluidics, Shear stress, Hydrodynamic forces

URI

https://www.sciencedirect.com/science/article/pii/B9780128133392000153
https://hdl.handle.net/11511/76418
https://www.sciencedirect.com/science/article/pii/B9780128133392000153

Relation

Handbook of Nanomaterials for Cancer Theranostics

Collections

Biomaterials and Tissue Engineering Application and Research Center (BİOMATEN), Book / Book chapter

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Hydrogels as a New Platform to Recapitulate the Tumor Microenvironment Hasırcı, Nesrin; Ermiş Şen, Menekşe; Güven, Sinan; Durmuş, Gözde; Rizvi, İmran; Hasan, Tayyaba; Demirci, Utkan; Hasırcı, Vasıf Nejat (Elsevier Science, 2018-06-01) Recent advances in tissue engineering include the incorporation of multiple cell types into three-dimensional (3D) hydrogels to recapitulate extracellular matrix (ECM) structures and the functionality of living tissues in vitro. For decades, researchers have been investigating the complex mechanisms of cancer metastasis, tumorigenesis, and angiogenesis over two-dimensional (2D) monolayer cell culture models, or in vivo animal models. Increasing numbers of unsuccessful clinical trials for cancer therapy indi...
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Citation Formats

M. Ermiş Şen et al., Hydrogels as a New Platform to Recapitulate the Tumor Microenvironment. 2018, p. 494.