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Doksorubisin üklü Dekstran kaplı manyetik nanoparçacıkların MCF-7 meme kanseri hücre hattında sitokin genlerinin ifade düzeyleri üzerindeki etkileri
Date
2017-02-23
Author
Yalçın Azarkan, Serap
Mutlu, Pelin
Gündüz, Ufuk
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https://hdl.handle.net/11511/83832
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Doksorubisin dirençli ve duyarlı meme kanseri hücre hatlarında hücre yüzey yükü farkının moleküler düzeyde belirlenmesi
Gündüz, Ufuk; Külah, Haluk(2016-12-31)
Literatürde var olan çalışmalar, meme kanseri hücrelerinin elektriksel yüzey yüklerinin, sağlıklı hücrelerden daha yüksek olduğunu göstermiştir. Yapılan son çalışmalarımızdan birinde ise anti-kanser özellikte bir ilaç olan Doksorubisin'e dirençli meme kanseri hücrelerinin yüzey yüklerinin, ilaca duyarlı kanser hücrelerinden daha yüksek olduğu belirlenmiştir. Bu projede öncelikle MCF-7 meme kanseri ve Doksorubisin dirençli MCF-7 meme kanseri hücrelerinin çeşitli pH’lardaki (asidik, bazik ve nötr solüsyonlard...
Metastatic behaviour of doxorubicin resistant MCF-7 breast cancer cells after Vimentin silencing
Tezcan, Okan; Gündüz, Ufuk; Department of Biology (2013)
Chemotherapy is one of the common treatments in cancer therapy. The effectiveness of chemotherapy is limited by several factors one of which is the emergence of multidrug resistance (MDR). MDR is caused by the activity of diverse ATP binding cassette (ABC) transporters that pump drugs out of the cells. There are several drugs which have been used in treatment of cancer. One of them is doxorubicin that intercalates and inhibits DNA replication. However, doxorubicin has been found to cause development of MDR ...
The Effects of doxorubicin containing poly (sebacic anhydride) nanocapsules on glutathione s-transferase activity
Çokça, Ceren; Hasırcı, Nesrin; İşgör, S. Belgin; Department of Biomedical Engineering (2015)
Nanocapsules are used as drug delivery system commonly. Poly (sebacic anhydride) is a good candidate for the nanocapsule preparation since they are ideal for controlled release application with respect to biocompatibility, low cost, and the approval by US Food and Drug Administration (FDA). The overactivity of glutathione S-transferase is generally related with the resistance of chemotherapy and this problem can be overcome through drug delivery systems. In this study, poly (sebacic anhydride) - poly (ethyl...
Reversal of multidrug resistance in mcf-7 breast adenocarcinoma cell line by silencing interleukin 6 with RNA interference
Çakmak, Neşe; Gündüz, Ufuk; Department of Biology (2013)
Multidrug resistance (MDR) in cancer is characterized by development of resistance to several unrelated drugs upon long time administration of a certain type of chemotherapeutic agent. In doxorubicin resistant MCF-7 cell line, resistance is developed mainly by upregulation of MDR1 gene which encodes an ABC transporter protein known as P-glycoprotein. Interleukin 6 (IL-6) is a cytokine which acts as a growth factor for certain cell types including some cancer cells. IL-6 is found at high levels in cancer pat...
Reversal of multidrug resistance by small interfering rnas (sirna) in doxorubicin resistant mcf-7 breast cancer cells
Dönmez, Yaprak; Gündüz, Ufuk; Department of Biology (2010)
Resistance to anticancer drugs is a serious obstacle to cancer chemotherapy. A common form of multidrug resistance (MDR) is caused by the overexpression of transmembrane transporter proteins P-glycoprotein and MRP1, encoded by MDR1 and MRP1 genes, respectively. These proteins lead to reduced intracellular drug concentration and decreased cytotoxicity by means of their ability to pump the drugs out of the cells. Breast cancer tumor resistance is mainly associated with overexpression of P-gp/MDR1. Although so...
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S. Yalçın Azarkan, P. Mutlu, and U. Gündüz, “Doksorubisin üklü Dekstran kaplı manyetik nanoparçacıkların MCF-7 meme kanseri hücre hattında sitokin genlerinin ifade düzeyleri üzerindeki etkileri,” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/83832.