Design of Zeolite Modified Electrodes and Their Influence on Biosensor Performance

Date

2016-11-27

Author

Ozansoy Kasap, Berna
Akata Kurç, Burcu

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Enzyme-based biosensors have been of intense investigation and field-effect transistor (FET)-based sensors are one of the widely produced, miniaturized silicon-based semiconductor devices used to quantify ion concentrations in the analyte solution. Overall, current research has focused on enhancement of the sensitivity, detection limit, selectivity and the storage stability of these electrochemical biosensors. For this purpose, variety of modification methods on electrochemical biosensor surfaces is proposed. At present, use of new nanosized materials in biosensor design is a promising approach to improve analytical characteristics of the devices. Zeolites are perspective nanomaterials for biosensor modification. They are inorganic compounds, the structure of which is a crystal lattice consisting of alumina and silica tetrahedra bound by oxygen atoms. This framework forms a lot of pores and channels which considerably increases the zeolite surface. In the current study, a review on precise control over structural and chemical properties of zeolites and their consequent effect on electro-chemical biosensors will be given. All results suggest that the methodology of surface immobilization and zeolitic properties such as Si/Al ratio, surface roughness, particle size, hydrophilicity and the ability to create gold nanoparticles within the nanopores effect and ultimately enhance the biosensor sensitivity and stability. Considering the important biological role of urea as a diagnostic indicator of kidney failure and major uremic toxin, its determination was needed in medical diagnostics. It was shown that distinction of healthy people from people with renal dysfunction became easier by zeolite modified biosensors. Our results show that the performance of constructed ISFET-type biosensors strongly depends on Si/Al ratio of employed zeolite nanoparticles as well as the type of enzymatic reaction employed. All fabricated biosensors demonstrated high signal reproducibility and stability. The obtained results were used for the development and design for an experimental prototype of novel nanobiosensor located implant.

URI

https://hdl.handle.net/11511/85554

Conference Name

Materials Research Society Meeting Fall 2016, ( 27 Kasım - 02 Aralık 2016)

Collections

Graduate School of Natural and Applied Sciences, Conference / Seminar

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Citation Formats

B. Ozansoy Kasap and B. Akata Kurç, “Design of Zeolite Modified Electrodes and Their Influence on Biosensor Performance,” presented at the Materials Research Society Meeting Fall 2016, ( 27 Kasım - 02 Aralık 2016), 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/85554.