Department of Biology

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Recent Submissions

Archaeogenomic analysis of genetic and cultural interactions in Neolithic Anatolian societies (NEOGENE)
Somel, Mehmet; Atakuman, Çiğdem; Sürer, Elif(2023)
The Neolithic Transition in the Near East (c.10,000-6,000 BC) was a period of singular sociocultural change, when societies adopted sedentary life and agriculture for the first time in human history. This project will join...
The structural effects of Vitamin A deficiency on biological macromolecules due to ethanol consumption and withdrawal: An FTIR study with chemometrics
ELİBOL, BİRSEN; Severcan, Mete; Jakubowska-Dogru, Ewa; DURSUN, İLKNUR; Severcan, Feride (2022-04-01)
The structural effects of vitamin A-deficiency were examined on the molecular profiles of biomolecules of male rat hippocampus during prolonged ethanol intake/withdrawal using FT-IR spectroscopy coupled with chemometrics. ...
TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior.
Yanpallewar, Sudhirkumar; Tomassoni-Ardori, Francesco; Palko, Mary Ellen; Hong, Zhenyi; Kiriş, Erkan; Becker, Jodi; Fulgenzi, Gianluca; Tessarollo, Lino (2022-03-17)
Recent studies have suggested that the use of cognitive enhancers as adjuncts to exposure-based therapy in individuals suffering from post-traumatic stress disorder (PTSD) may be beneficial. Brain cholinergic signaling thr...
Genetic diversity and population structure of Salix alba across river systems in Turkey and their importance in conservation management
Özdemir Değirmenci, Funda; Çiftçi, Asiye; Acar, Pelin; Kaya, Zeki (2022-03-01)
Background Salix alba is a pioneer species of river ecosystems throughout Turkey. Its genetic diversity and population structure across these ecosystems is currently unknown. Aims We investigated genetic diversity in Turki...
Broad maternal geographic origin of domestic sheep in Anatolia and the Zagros
Her, Charlotte; Rezaei, Hamid-Reza; Hughes, Sandrine; Naderi, Saeid; Duffraisse, Marilyne; Mashkour, Marjan; Naghash, Hamid-Reza; Balasescu, Adrian; Luikart, Gordon; Jordan, Steve; Ozut, Deniz; KENCE, AYKUT; Bruford, Michael W.; Tresset, Anne; Vigne, Jean-Denis; Taberlet, Pierre; Hanni, Catherine; Pompanon, Francois (2022-03-01)
We investigated the controversial origin of domestic sheep (Ovis aries) using large samples of contemporary and ancient domestic individuals and their closest wild relatives: the Asiatic mouflon (Ovis gmelini), the urial (...
Xenogenic Neural Stem Cell-Derived Extracellular Nanovesicles Modulate Human Mesenchymal Stem Cell Fate and Reconstruct Metabolomic Structure
DERKUŞ, BURAK; Isik, Melis; Eylem, Cemil Can; ERGİN, İREM; Camci, Can Berk; Bilgin, Sila; ELBÜKEN, ÇAĞLAR; ARSLAN, YAVUZ EMRE; Akkulak, Merve; Adalı, Orhan; KIRAN, FADİME; Okesola, Babatunde O.; NEMUTLU, EMİRHAN; EMREGÜL, EMEL (2022-03-01)
Extracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to ...
Present and historical landscape structure shapes current species richness in Central European grasslands
Scherreiks, Pascal; Gossner, Martin M.; Ayasse, Manfred; Bluethgen, Nico; Fischer, Markus; Klaus, Valentin H.; Kleinebecker, Till; Neff, Felix; Prati, Daniel; Seibold, Sebastian; Simons, Nadja K.; Weisser, Wolfgang W.; Wells, Konstans; Westphal, Catrin; Thiele, Jan; Ambarlı, Didem (2022-03-01)
Context Current diversity and species composition of ecological communities can often not exclusively be explained by present land use and landscape structure. Historical land use may have considerably influenced ecosystem...
Development of ACE2 loaded decoy liposomes and their effect on SARS-CoV-2 for Covid-19 treatment
Arısoy, Sema ; Kocas, Meryem; Çomoğlu, Tansel ; Güderer, İsmail; Banerjee, Sreeparna (2022-02-01)
SARS-CoV-2 is a novel coronavirus with a positively oriented single-stranded RNA that first appeared in December 2019. In this study, Angiotensin Converting Enzyme 2 (ACE2) loaded decoy liposomes were developed and charact...
Investigation of effects of hyperlipidemia on IRE1α and insulin pathway in the cerebral cortex of ApoE-/- mice
AK, Deniz; Yanık, Tülin; Department of Molecular Biology and Genetics (2022-1-20)
Obesity prevalence increases worldwide. The most crucial reason for obesity is high-fat diet (HFD). Serum fatty acid levels are increased with HFD, inducing inflammation and glucose homeostasis disruption, leading to insul...
Corrosion Resistance and Cytocompatibility of Magnesium-Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings
TAMAY, DİLARA GÖKSU; Gokyer, Seyda; Schmidt, Jurgen; Vladescu, Alina; HURİ, PINAR; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2022-01-12)
In orthopedic surgery, metals are preferred to support or treat damaged bones due to their high mechanical strength. However, the necessity for a second surgery for implant removal after healing creates problems. Therefore...
Establishment of Human Induced Pluripotent Stem Cells from Multiple Sclerosis Patients.
Begentaş, Onur Can; Koc, Dilara; Kiris, Erkan (2022-01-06)
The patient-derived iPSC lines provide valuable resources as these cells can be utilized to generate human cell types relevant to the disease of interest. In this context, human iPSC-based model systems are particularly us...
Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency
Yilmaz, Naz Surucu; et. al. (2022-01-01)
NF-kappa B essential modulator (NEMO, IKK-gamma) deficiency is a rare combined immunodeficiency caused by mutations in the IKBKG gene. Conventionally, patients are afflicted with life threatening recurrent microbial infect...
Expanding the Clinical and Immunological Phenotypes and Natural History of MALT1 Deficiency
Sefer, Asena Pinar; et. al. (2022-01-01)
Purpose MALT1 deficiency is a combined immune deficiency characterized by recurrent infections, eczema, chronic diarrhea, and failure to thrive. Clinical and immunological characterizations of the disease have not been pre...
Genome-Wide Diversity of MADS-Box Genes in Bread Wheat is Associated with its Rapid Global Adaptability
Raza, Qasim; Riaz, Awais; Atif, Rana Muhammad; Hussaın, Babar; Rana, Iqrar Ahmad; Ali, Zulfiqar; Budak, Hikmet; Alaraidh, Ibrahim A. (2022-01-01)
MADS-box gene family members play multifarious roles in regulating the growth and development of crop plants and hold enormous promise for bolstering grain yield potential under changing global environments. Bread wheat (T...
Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity
İzgi, Hamit; Han, Dingding; Isildak, Ulas; Huang, Shuyun; Kocabiyik, Ece; Khaitovich, Philipp; Somel, Mehmet; Dönertaş, Handan Melike (2022-01-01)
Developmental trajectories of gene expression may reverse in their direction during ageing, a phenomenon previously linked to cellular identity loss. Our analysis of cerebral cortex, lung, liver and muscle transcriptomes o...
Molecular phylogenetic analysis resolving the taxonomic discrepancies among Salix L. species naturally found in Turkey
Acar, Pelin; Değirmenci, Funda Ö.; DUMAN, HAYRİ; Kaya, Zeki (2022-01-01)
© 2022, Polska Akademia Nauk. All rights reserved.Detailed phylogenetic relationships and molecular dating are still quite rare for the complex and diverse genus Salix L. Here we focus on the taxonomic status and phylogeny...
The silent and dangerous inequity around access to COVID-19 testing: A call to action Comment
Batista, Carolina; et. al. (2022-01-01)
Identification of an mRNA isoform switch for HNRNPA1 in breast cancers.
Erdem, Murat; Ozgul, İbrahim; Dioken, Didem Naz; Gurcuoglu, Irmak; Guntekin Ergun, Sezen; Cetin-Atalay, Rengul; Can, Tolga; Erson Bensan, Ayşe Elif (2021-12-27)
Roles of HNRNPA1 are beginning to emerge in cancers; however, mechanisms causing deregulation of HNRNPA1 function remain elusive. Here, we describe an isoform switch between the 3′-UTR isoforms of HNRNPA1 in breast cancers...
Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases.
Kiriş, Erkan (2021-12-19)
Regulation of Gene Expression- Chapter End Problem Set
Terzi Çizmecioğlu, Nihal (Pearson Education, 2021-12-01)
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