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Recent Submissions

Development of benzofuran-based 1,3,4-oxadiazole hybrids as potential BRD4 inhibitors and antidiabetic activities UZUNER, UĞUR; İzgi, Samet; Celik-Uzuner, Selcen; Sengul, Ibrahim F.; AYAZOĞLU DEMİR, ELİF; Bingul, Murat; Sahin, Hasan; Son, Çağdaş Devrim; Uslu Uçar, Tugçe Nur; Kandemir, Hakan (2026-10-15) This study aimed to design and synthesize novel benzofuran-based 1,3,4-oxadiazole hybrids and evaluate their potential as bromodomain-containing protein 4 (BRD4) inhibitors with antidiabetic activities. For this purpose, 4...
Nitrogen sources and concentrations shape algal odor compounds: Key drivers of <i>β</i>-cyclocitral and <i>β</i>-ionone in water bodies of the lower Yangtze River Yin, Sicheng; Hu, Youyin; Xing, Yawei; Wang, Xianyun; Jeppesen, Erik; Wang, Liqing; Zhang, Wei (2026-10-01) Taste and odor (T&O) compounds derived from cyanobacterial blooms pose escalating threats to freshwater security worldwide, yet the drivers of specific T&O metabolites remain poorly constrained. Here, we investigated the d...
A comparison of ancient DNA yields across ossicles and the petrous bone reveals the best preservation in the stapes and incus Sağlıcan, Ekin; Sevkar, Arda; Kazancı, Duygu Deniz; Oteo-García, Gonzalo; Yorulmaz, Sevgi; Vural, Kıvılcım Başak; Çakan, Gökhan; Adiloğlu, Gökçen; Buldak, Duru; Duru, Güneş; Öztan, Aliye; Hassett, Brenna; Kayacan, Nurcan; Özdoğan, Aslı Erim; Götherström, Anders; ÖZER, FÜSUN; Erdal, Ömür Dilek; ERDAL, YILMAZ SELİM; Somel, Mehmet (2026-08-03) The petrous bone is considered the most efficient source of endogenous DNA across skeletal tissues in ancient DNA (aDNA) research as well as in forensic work. Recently, aDNA in auditory ossicle bones was shown to be compar...
Contrasting responses of fish taxonomic and functional diversity to eutrophication in Danish shallow lakes Mao, Zhigang; Cao, Yong; Quirino, Bárbara Angélio; Zhou, Libin; Søndergaard, Martin; Lauridsen, Torben Linding; Johansson, Liselotte Sander; Gu, Xiaohong; Jeppesen, Erik (2026-07-21) (Figure presented)
RNAGEN: A Generative Adversarial Network-Based Model to Generate Synthetic RNA Sequences to Target Proteins Ozden, Furkan; Barazandeh, Sina; Akboga, Dogus; Tabrizi, Sobhan Shokoueian; Şeker, Urartu Özgür Şafak; Cicek, A. Ercument (2026-07-14) Background: RNA—protein binding plays an important role in regulating protein activity by affecting localization and stability. While proteins are usually targeted via small molecules or other proteins, easy-to-design and ...
Biotinylated Diaryl Isoxazole Derivatives with Enhanced Janus Kinase 1 Inhibitory, Antiproliferative, and Apoptotic Activities in Cancer Cells Ergüven, Melike; Çatalak Yılmaz, Hazal Beril; LENGERLİ, DENİZ; Acar, Rana; Bagheralmoosavi, Servin; Carus Şahin, Yağmur Öykü; Gürçay, Mehmet; ÇALIŞKAN, BURCU; Banerjee, Sreeparna; Yesiloz, Gurkan; Konu, Ozlen; BANOĞLU, ERDEN; Cizmecioglu, Onur (2026-06-30) Isoxazole derivatives have emerged as promising scaffolds in anticancer drug discovery, yet their therapeutic potential remains to be fully harnessed. Here, we report on the synthesis and biological evaluation of two novel...
Summer temperature variations over the past 20,000 years and their influence on carbon burial in a wetland on the NE Tibetan plateau Li, Yuan; Zhang, Hui; Jiang, Gaolei; Wang, Wenjia; Wang, Tao; Zhang, Jun; Xiang, Lixiong; Sun, Mingjie; Jeppesen, Erik; Song, Lei; Huang, Xiaozhong (2026-06-01) Carbon burial in wetlands of the Tibetan Plateau is a critical component of the global carbon cycle, yet its response to global warming remains poorly understood. We investigated how summer temperature variations over the ...
The Tie That Binds Us? Challenging the Primacy of DNA in Kinship Studies and Re-Centring Community in Defining Human Connections across Time Moots, Hannah M.; Tsosie, Krystal S.; Somel, Mehmet (2026-05-01) Biological determinism continues to shape how kinship is defined, from research to repatriation proceedings. This privileging of biological relatedness reflects and reinforces dominant ‘Western’ frameworks of kinship, ofte...
Water Chemistry and Habitat Size Predict Spawning Success in Endangered Hynobius yangi: Feeding Ecology and Implications for Urban Wetland Design Gim, Jeong-Soo; Choi, Yoseok; Bae, Seoyoon; Kim, Kanghui; Hong, Suk-Hwan; An, Mi-Yeon; Jeppesen, Erik; Joo, Gea-Jae; Jo, Hyunbin (2026-05-01) Urbanization threatens amphibians through habitat loss and fragmentation. The critically endangered Hynobius yangi, endemic to Korea, faces severe habitat destruction from urban development. No previous study has simultane...
Selection of Appropriate Reference Genes in Apoe-/- Mouse Brain Mengi, Naz; Yanık, Tülin; Adams, Michelle (2026-04-01) BackgroundReverse transcription quantitative real-time polymerase chain reaction is the gold standard for gene expression quantification. Yet, this method’s accuracy heavily depends on choosing appropriate reference genes ...
Synergistic regulation of photosynthetic efficiency at physiological and transcriptional levels in Ottelia acuminata under single and combined nitrogen and phosphorus treatments Zhou, Xiong-Li; Dai, Ni-Fei; Wang, Si-Qi; Rui-Zhang, Rui-Zhang; Lyu, Zhen-Yu; Jeppesen, Erik; Yang, Liu; Shen, Shi-Kang (2026-04-01) Eutrophication in plateau lakes is a major global challenge driven by excessive nitrogen (N) and phosphorus (P) inputs ; however, whether N or P is the dominant limiting nutrient remains controversial. To address this issu...
Hydrological period conversions induce micro-eukaryotic community homogenization along the eastern route of China's South-to-North Water Diversion Project Peng, Kai; Qin, Zhirui; Feng, Tao; Jeppesen, Erik; Wei, Jiahao; Liu, Jiayuan; Cai, Yongjiu; Gong, Zhijun (2026-03-01) How hydrological period conversions, including the water diversion period (WDP) and flood discharge period (FDP), influence microbial communities, their assembly mechanisms, and community stability remains poorly understoo...
M2 macrophage-derived extracellular vesicles induce EMT-like transcriptional reprogramming in colorectal cancer cells via upregulation of FAM83A. Isik, Melis; Akkulak, Merve; Derkus, Burak (2026-02-19)
Engineered probiotics recruit CAR macrophages and establish immune memory to eradicate heterogeneous glioblastoma in mice Zhang, Yulin; et. al. (2026-02-11) Glioblastoma (GBM) remains a highly lethal form of cancer due to its molecular heterogeneity and the immunosuppressive microenvironment surrounding the tumor. Here, we report a modular immunotherapy platform characterized ...
Api-TRACE: A system for honey bee tracking in a constrained environment to study bee learning process and the effect of lithium on learning Erdem, Babür; Ince, Ayben; SEVİN, SEDAT; Arslan, Okan Can; Gözen, Ayşe Gül; Giray, Tugrul; Alemdar, Hande (2026-02-01) Learning is an adaptive behavior that improves the performance of bees in foraging, dance communication, predator avoidance, and other tasks. Any deficiencies in learning could be detrimental to the long-term survival of t...
Insight into greenhouse gas emission in freshwater aquaculture ponds in Jiangsu Province: Variation due to species used and ponds management practice Li, Yifan; Wang, Hongyu; Zeng, Qingfei; Jeppesen, Erik; Gu, Xiaohong; Yan, Jie (2026-02-01) Aquaculture ponds have emerged as a significant contributor to greenhouse gas (GHG) emissions. We measured methane (CH4), carbon dioxide (CO2), and nitrous oxide (N2O) emissions in ponds, all located in Jiangsu Province, w...
Larger crustacean zooplankton thrive at lower temperatures and under reduced predation in pond ecosystems Rincon-Palau, Katterine; Badosa, Anna; Avci, Feride; Bartrons, Mireia; Beklioğlu, Meryem; Boix, Dani; Cuenca-Cambronero, Maria; Davidson, Thomas A.; Lacerot, Gissell; Lemmens, Pieter; Martin, Luis; Meerhoff, Mariana; Mehner, Thomas; Wijns, Robby; Brucet, Sandra (2026-01-26) Body size is a fundamental trait influencing ecological functions, trophic dynamics, and organismal fitness across ecosystems. However, the environmental drivers shaping body size patterns in pond ecosystems across broad s...
Diet and Mobility in Byzantine Western Anatolia: Carbon and Nitrogen Isotopic Ratios and Ancient DNA Evidence from Barcın Höyük and Kadıkalesi Anaia Ozbal, Rana; BÜYÜKKARAKAYA, ALİ METİN; UYSAL, GÜLFEM; Butun, Erge; Gerritsen, Fokke; Akbaba, Ali; ALTINIŞIK, NEFİZE EZGİ; Somel, Mehmet (2026-01-20) This study presents the integrated results of stable carbon (delta 13C) and nitrogen (delta 15N) isotope and aDNA analyses, conducted to examine dietary and mobility practices in two mid- to late Byzantine communities in w...
Development of Artemisia absinthium-Enriched β-Glucan Nanoparticle-Based Nanofibers: Physicochemical Characterization and In Vitro Bioactivity Arik, Nehir; Tosun, Barış Çağrı; KAYMAK, SİBEL; VURAL, NİLÜFER; Servatan, Morteza; BOZKURT, FATMA ZEYNEP; MUTLU, PELİN; Tezcaner, Ayşen; CANSARAN DUMAN, DEMET; Öktem, Hüseyin Avni (2026-01-01) Persistent and hard to heal wounds require dressings that do more than cover the injured site; they must also support cell contact and enable local presentation of bioactive compounds. In this study, electrospun polycaprol...
Seasonality and functional traits of periphytic algae shape zooperiphyton colonization de Moura Falcão, Rafael Henrique; Alves Amorım, Cıhelıo; da Silva, Gaibel Vieira Assumpção; do Nascimento Moura, Ariadne (2026-01-01) We investigated the influence of seasonality and the phycoperiphyton on the colonization dynamics of zooperiphyton on artificial polyethylene terephthalate substrates in a tropical hypereutrophic reservoir. We tested the h...

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