A QSAR study of the biological activities of some benzimidazoles and imidazopyridines against Bacillus subtilis

1995-04-01
Ertepınar, Hamide
Gök, Yaşar
Geban, Ömer
Özden, Seçkin
A set of benzimidazole (I) and imidazopyridine (II) derivatives that have previously been tested for their antibacterial activities against Bacillus subtilis were analyzed using the quantitative structure-activity relationship (QSAR) method. The activity contributions for structural and substituent effects were determined from the correlation equations, which were derived using all possible combination and stepwise regression techniques. The best equation was chosen among the other equations by considering the various statistical criteria. The resulting QSAR revealed that the activity contributions of benzimidazoles and imidazopyridines against B subtilis depend almost entirely on their relative lipophilic character as defined by their octanol/water partition coefficients, log P. The ideal lipophilic character for the investigated imidazole nuclei has been found to be about 4.9.
European Journal Of Medicinal Chemistry

Suggestions

Comparative analysis of product and by-product distributions in defined and complex media in serine alkaline protease production by recombinant Basillus subtilis
Oktar, Ceren; Çalık, Pınar; Department of Chemical Engineering (2003)
In this study, firstly the effects of aspartic acid group amino acids -which were reported to be the potential bottleneck in serine alkaline protease (SAP) synthesis- on SAP production were investigated by substituting at a concentration range of 0-15 mM by using recombinant Bacillus subtilis carrying pHV1434::subC gene. All aspartic acid group amino acids except threonine inhibited SAP activity when CAA= 2.5 mM. The highest SAP activities with asparagine, aspartic acid, lysine, threonine, isoleucine and me...
The Analysis of the restriction site polymorphism in the mitochondrial DNA sequences of the industrially used saccharomyces cerevisiae strains Industrially Used Saccharomyces Cerevisiae Strains
İzgü, Kadri Fatih; Demet, Altınbay; Gün, Hüseyin (1996-01-01)
A Prostate Cancer Model Build by a Novel SVM-ID3 Hybrid Feature Selection Method Using Both Genotyping and Phenotype Data from dbGaP
Yucebas, Sait Can; Aydın Son, Yeşim (2014-03-20)
Through Genome Wide Association Studies (GWAS) many Single Nucleotide Polymorphism (SNP)-complex disease relations can be investigated. The output of GWAS can be high in amount and high dimensional, also relations between SNPs, phenotypes and diseases are most likely to be nonlinear. In order to handle high volume-high dimensional data and to be able to find the nonlinear relations we have utilized data mining approaches and a hybrid feature selection model of support vector machine and decision tree has be...
The Functional assessment of fluorescently tagged adenosine A2A and dopamine D2 receptors and qualitative analysis of dimerization of adenosine A2A and dopamine D2 receptor by using FRET
Akkuzu, Selin; Son, Çağdaş Devrim; Department of Biology (2013)
Recently, several studies have demonstrated that G protein coupled receptors exist as homo/heterodimers or oligomers. Adenosine A2A receptors and dopamine D2 receptors are present as both homo- and heterodimer. In the GABAergic striatopallidal neurons A2AR are co- localized with D2 receptors (D2R), and establish functional A2AR-D2R heteromers, which modulates dopaminergic activity. Due to be involved in physiological processes, these receptors bear critical roles. Dopamine receptors play critical role in do...
Projektif Yöntem Olarak Rorschach Testi ile Psikozun İncelenmesi
Göçer, Kübra (Orta Doğu Teknik Üniversitesi (Ankara, Turkey), 2018-10-22)
Klinik psikoloji uygulamalarında psikopatolojileri tespit etmek amaçlı çeşitli metodlar kullanılmaktadır. Rorschach Testi, niteliksel veriler sunan ve bir projektif test olarak bilinen, bu metodlardan bir tanesidir. Öncelikle projektif testlerle beraber Rorschach Testi’nin tarihçesi, uygulanışı ve yorumlanması tanıtıldıktan sonra, psikozun bu testin protokollerine nasıl yansıdığı ele alınacaktır. Psikotik yapılanmaların ortak özellikleriyle beraber psikotik endişe incelenecektir. Bu ortak özelliklerin...
Citation Formats
H. Ertepınar, Y. Gök, Ö. Geban, and S. Özden, “A QSAR study of the biological activities of some benzimidazoles and imidazopyridines against Bacillus subtilis,” European Journal Of Medicinal Chemistry, pp. 171–175, 1995, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/87320.