Large Eddy Simulation of Blood Flow Inside Vessels for Acoustic Diagnosis of Atherosclerosis

Date

2018-10-20

Author

Sert, Cüneyt
Yazıcıoğlu, Yiğit

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

209
views

0
downloads

Atherosclerosis is a cardiovascular disease, in which plaque builds up inside a blood vessel, narrowing it down and forming a stenosis that adversely affects flow. Because of the constriction, turbulent flow occurs at the post-stenotic region, which leads pressure fluctuations on the vessel wall. The murmur caused by this interaction propagates through the surrounding tissue and reaches the skin surface. These sounds emitted from the stenosed vessels are evaluated as a sign of stenosis. In this study, large eddy simulations are conducted to investigate the turbulence-induced wall pressure fluctuations and resulting acoustic emission. The two main parameters considered for this purpose are the stenosis severity and shape. The results show that stenosis severity under a certain level does not cause disturbance at the post-stenotic region. For constrictions above this critical level, increasing stenosis severity has an intensifying effect on the wall pressure fluctuations. Eccentric stenosis morphology causes more severe fluctuations than the axisymmetric one. Different stenosis shapes affect both the magnitude of fluctuations and the duration in which the fluctuations are intense during the pulsatile cycle. Obtained pressure fluctuations are converted into sound and investigated in terms of sound levels and patterns. Sounds emitted from the vessels with different stenosis severities and shapes have different sound characteristics, and they can provide important information about the constriction. Therefore, both the stenosis severity and the shape must be taken into account for development of an acoustic-based diagnostic system.

Subject Keywords

Cardiovascular biomechanics, Pressure fluctuation, Non-invasive diagnosis of stenosis, Acoustic radiation, Stenosis severity, Stenosis shape, Large Eddy Simulation (LES)

URI

https://hdl.handle.net/11511/89085

Collections

Department of Mechanical Engineering, Conference / Seminar

Suggestions

OpenMETU
Core

Large eddy simulation of pressure fluctuations inside stenosed blood vessels towards noninvasive diagnosis of atherosclerosis Özden, Kamil; Sert, Cüneyt; Yazıcıoğlu, Yiğit; Department of Mechanical Engineering (2018) Atherosclerosis is a cardiovascular disease, in which plaque builds up inside a blood vessel, narrowing it down and forming a stenosis that adversely affects the flow. Because of the stenosis, turbulent flow occurs at the post-stenotic region, which causespressure fluctuations on the vessel wall. The resulting murmurpropogates through the surrounding tissue and reaches the skin surface. These sounds emitted from the stenosed vessels are evaluated as a sign of stenosis. In this study, large eddy simulations ...
Non-invasive acoustic detection of vascular diseases from skin surface using computational techniques with fluid-structure interaction Salman, Hüseyin Enes; Yazıcıoğlu, Yiğit; Ciğeroğlu, Ender; Department of Mechanical Engineering (2018) Atherosclerosis is a cardiovascular disease in which arterial occlusion adversely affects blood circulation. Because of the narrowing of the artery, the blood flow is disturbed and a recirculating flow occurs at the downstream of the stenosis exit. The dynamic pressure fluctuations on the inner arterial wall cause the blood vessel wall to vibrate and the resulting acoustic energy propagates through the surrounding soft tissue and reaches the skin surface. To understand the problem in more detail, computatio...
Investigation of fluid structure interaction in cardiovascular system from diagnostic and pathological perspective Salman, Hüseyin Enes; Yazıcıoğlu, Yiğit; Sert, Cüneyt; Department of Mechanical Engineering (2012) Atherosclerosis is a disease of the cardiovascular system where a stenosis may develop in an artery which is an abnormal narrowing in the blood vessel that adversely affects the blood flow. Due to the constriction of the blood vessel, the flow is disturbed, forming a jet and recirculation downstream of the stenosis. Dynamic pressure fluctuations on the inner wall of the blood vessel leads to the vibration of the vessel structure and acoustic energy is propagated through the surrounding tissue that can be de...
Computational analysis for non-invasive detection of stenosis in peripheral arteries Salman, Huseyin Enes; Yazıcıoğlu, Yiğit (Elsevier BV, 2019-08-01) Atherosclerosis usually affects the entire cardiovascular system, including peripheral blood vessels. Peripheral arterial stenosis may indicate possible serious vascular disorders related to more vital organs. If peripheral arterial stenosis can be discerned at an early stage, it can serve as a warning sign to take precautions, such as using more invasive diagnostic techniques or adopting a healthier life style. In this study, peripheral regions, such as the thigh, upper arm, and neck are modelled consideri...
Assessment of the impacts of hyperlipidemia on brain and modulation of perk pathway against hyperlipidemia- induced synaptic impairment on hippocampus Aşkın, Bilge; Yanık, Tülay.; Department of Molecular Biology and Genetics (2019) Hyperlipidemia is characterized by elevated total cholesterol levels in the circulation, and it is often associated with co-occurrence of neuronal dysfunction and subsequent neurodegeneration. Hyperlipidemia-induced inflammation, synaptic damage and neuronal loss in hippocampus as well as in other regions of the brain consequently leads to cognitive decline. Due to its role in protein translation and cell fate determination, PKR-like endoplasmic reticulum kinase (PERK) arm of the Endoplasmic Reticulum (ER) ...

Citation Formats

C. Sert and Y. Yazıcıoğlu, “Large Eddy Simulation of Blood Flow Inside Vessels for Acoustic Diagnosis of Atherosclerosis,” 2018, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/89085.