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A novel enantioselective synthesis of o-Thienyl alkyl amines
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023252.pdf
Date
1992
Author
ibrahimzade, Nezire
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https://hdl.handle.net/11511/8932
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Graduate School of Natural and Applied Sciences, Thesis
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A novel synthesis of 1,2,4-oxadiazoles and isoxazoles is described by utilizing the reactions between amidoximes and alpha,beta-alkynic aldehydes and/or ketones. Conjugate addition products, obtained from amidoximes and alpha,beta-alkynic aldehydes and/or ketones, afford 1,2,4-oxadiazoles and isoxazoles when treated with bases and acids, respectively. 1,2,4-Oxadiazoles can also be synthesized directly from amidoximes and alpha,beta-alkynic aldehydes in a one-pot manner under basic conditions. The reactions ...
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N. ibrahimzade, “A novel enantioselective synthesis of o-Thienyl alkyl amines,” MIDDLE EAST TECHNICAL UNIVERSITY, 1992.