Fullerol based enzyme mimics and synthesis effort of tetra aryl pyranone

Soydan, Medine
Although, natural enzymes have high catalytic activity and specificity, they are fragile and costly due to long purification processes. Therefore, scientists started to design and synthesize structures with enzyme-like activity called nanozymes to overcome the limitations of the natural enzymes. In the first part of this project, amino acids of catalytic site of three enzymes were conjugated into fullerol.The names of three enzymes are lactate dehydrogenase, protease and nitrilase.Then, the catalytic activity of fullerol amino acid derivatives was tested with the model reactions.Luminescence was observed and attracted attention throughout the history. Accordingly, understanding of the luminescence made great progress. Aggregation caused quenching and the aggregation induced emission processes are the relatively new concept in the comprehension of luminescence. Moreover, newmolecules which show ACQ or AIE property are designed and synthesized for various applications like imaging. In the second part of this project, it was aimed to synthesize 2,3,4,5-tetraphenyl-4H-pyran-4-one by a new synthesis route. Moreover, it was planned to investigate whether it has aggregation caused quenching or the aggregation induced emission property with fluorescence spectroscopy.
Citation Formats
M. Soydan, “Fullerol based enzyme mimics and synthesis effort of tetra aryl pyranone,” M.S. - Master of Science, Middle East Technical University, 2021.