Fullerol based enzyme mimics and synthesis effort of tetra aryl pyranone

Soydan, Medine
Although, natural enzymes have high catalytic activity and specificity, they are fragile and costly due to long purification processes. Therefore, scientists started to design and synthesize structures with enzyme-like activity called nanozymes to overcome the limitations of the natural enzymes. In the first part of this project, amino acids of catalytic site of three enzymes were conjugated into fullerol.The names of three enzymes are lactate dehydrogenase, protease and nitrilase.Then, the catalytic activity of fullerol amino acid derivatives was tested with the model reactions.Luminescence was observed and attracted attention throughout the history. Accordingly, understanding of the luminescence made great progress. Aggregation caused quenching and the aggregation induced emission processes are the relatively new concept in the comprehension of luminescence. Moreover, newmolecules which show ACQ or AIE property are designed and synthesized for various applications like imaging. In the second part of this project, it was aimed to synthesize 2,3,4,5-tetraphenyl-4H-pyran-4-one by a new synthesis route. Moreover, it was planned to investigate whether it has aggregation caused quenching or the aggregation induced emission property with fluorescence spectroscopy.


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A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity.
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Cholinesterase enzymes are considered as one of the most important enzymes in living organisms and they are targeted by many inhibitors. Cholinesterase inhibitors are potentially toxic however they also have certain applications as treatment of dementia and Alzheimer’s diseases. These inhibitors can bind the active side of the cholinesterase enzymes forming stable complexes. This inhibitory effect can be used to construct fast and sensitive detection system. Also, conducting polymers are known to be well su...
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Photosynthetic bacterium Rhodobacter sphaeroides O.U.001 that is used for photobiohydrogen production can also accumulate poly-beta-hydroxybutyrate (PHB) as a by-product when cultivated anaerobically with minimal medium containing L-malic acid, sodium glutamate and some vitamins under illumination. Transmission electron microscopy studies revealed that PHB granules are made of two distinct components: a homogenous and electron lucent core is covered with a more electron dense coat. PHB granules were observe...
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Ciprofloxacin, a second-generation synthetic fluoroquinolone derivative widely used in human and veterinary medicines, has the potential to pose a serious risk to aquatic organisms and humans. The current research investigated the removal of ciprofloxacin using biochar treated with clay mineral and subsequently activated with carbon dioxide (CO2) produced at two different pyrolysis temperatures (350 and 650 °C). Batch adsorption experiments were carried out to assess the removal efficiency of ciprofloxacin ...
Citation Formats
M. Soydan, “Fullerol based enzyme mimics and synthesis effort of tetra aryl pyranone,” M.S. - Master of Science, Middle East Technical University, 2021.