Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management

Akkoyun, Emrah
Gharahi, Hamidreza
Kwon, Sebastian T.
Zambrano, Byron A.
Rao, Akshay
Acar, Aybar Can
Lee, Whal
Baek, Seungik
The maximum diameter measurement of an abdominal aortic aneurysm (AAA), which depends on orthogonal and axial cross-sections or maximally inscribed spheres within the AAA, plays a significant role in the clinical decision making process. This study aims to build a total of 21 morphological parameters from longitudinal CT scans and analyze their correlations. Furthermore, this work explores the existence of a “master curve” of AAA growth, and tests which parameters serve to enhance its predictability for clinical use. Methods: 106 CT scan images from 25 Korean AAA patients were retrospectively obtained. We subsequently computed morphological parameters, growth rates, and pair-wise correlations, and attempted to enhance the predictability of the growth for high-risk aneurysms using non-linear curve fitting and least-square minimization. Results: An exponential AAA growth model was fitted to the maximum spherical diameter, as the best representative of the growth among all parameters (r-square: 0.94) and correctly predicted to 15 of 16 validation scans based on a 95% confidence interval. AAA volume expansion rates were highly correlated (r=0.75) with thrombus accumulation rates. Conclusions: The exponential growth model using spherical diameter provides useful information about progression of aneurysm size and enables AAA growth rate extrapolation during a given surveillance period.
Computer Methods and Programs in Biomedicine


RAMAZANLI, BURCU; Yavuz, Mehmet Metin; Sert, Cüneyt; Department of Mechanical Engineering (2022-12-02)
Intraluminal thrombus (ILT) is a fibrin structure which might affect rupture characteristics and be observed 80% of abdominal aortic aneurysms (AAA). Disturbed hemodynamics inside AAA might affect ILT formation, that are generally quantified by wall shear stress (WSS) parameters in literature. Together with WSS parameters, vortex structures observed inside arterial systems can also be counted as indicators of disturbed hemodynamics, and might contribute the generation of ILT. To understand the effect of dis...
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The usual goal in inverse electrocardiography (ECG) is to reconstruct cardiac electrical sources from body surface potentials and a mathematical model that relates the sources to the measurements. Due to attenuation and smoothing that occurs in the thorax, the inverse ECG problem is ill-posed and imposition of a priori constraints is needed to combat this ill-posedness. When the problem is posed in terms of reconstructing heart surface potentials, solutions have not yet achieved clinical utility; limitation...
Forward problem of electrocardiography in terms of 3D transmembrane potentials using COMSOL
Bedir, Gizem; Serinağaoğlu Doğrusöz, Yeşim; Çetin, Barbaros; Department of Biomedical Engineering (2015)
Computation of body surface potentials from equivalent cardiac sources is called as forward problem of electrocardiography (ECG). There exist different solution meth- ods for solving the forward ECG problem. These solution methods depend on the choice of the equivalent cardiac sources. In this study, bidomain model based trans- membrane potential (TMP) distribution is used as equivalent cardiac source to exam- ine the cellular electrophysiology macroscopically. With this type of source defini- tion, the TMP...
Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques
Salman, Huseyin Enes; Ramazanlı, Burcu; Yavuz, Mehmet Metin; Yalcin, Huseyin Cagatay (2019-05-31)
Abdominal aortic aneurysm (AAA) is the dilatation of the aorta beyond 50% of the normal vessel diameter. It is reported that 4-8% of men and 0.5-1% of women above 50 years of age bear an AAA and it accounts for similar to 15,000 deaths per year in the United States alone. If left untreated, AAA might gradually expand until rupture; the most catastrophic complication of the aneurysmal disease that is accompanied by a striking overall mortality of 80%. The precise mechanisms leading to AAA rupture remains unc...
Feature discovery and classification of Doppler umbilical artery blood flow velocity waveforms
Baykal, Nazife; Yalabık, N.; Erkmen, Aydan Müşerref (Elsevier BV, 1996-11)
Doppler umbilical artery blood flow velocity waveform measurements are used in perinatal surveillance for the evaluation of fetal condition. There is an ongoing debate on the predictive value of Doppler measurements concerning the critical effect of the selection of parameters for the interpretation of Doppler waveforms. In this paper, we describe how neural network methods can be used both to discover relevant classification features and subsequently to; classify Doppler umbilical artery blood flow velocit...
Citation Formats
E. Akkoyun et al., “Defining a master curve of abdominal aortic aneurysm growth and its potential utility of clinical management,” Computer Methods and Programs in Biomedicine, pp. 0–0, 2021, Accessed: 00, 2021. [Online]. Available: