GENOTYPE CATALOG FOR THE ANALYSIS OF DRUG-DRUG INTERACTIONS

Download

thesis.pdf

Date

2021-9-07

Author

OZDEMIR, AYSE

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

369
views

527
downloads

Polypharmacy is an essential practice in today’s therapeutics, especially in the care of older population. Most polypharmacy-induced drug-drug interactions (DDIs) are often discovered after drugs are put on the market. Health problems and economic burden due to unpredicted DDIs put the health system in a difficult situation. Therefore, increasing the predictability of DDIs has become one of the most critical concerns towards improving treatment success. Being dependent on several underlying parameters makes DDIs challenging to foresee. One of the most significant determinants of these underlying parameters is genetic variability. Therefore, a more profound knowledge of the DDI-genetic relationship, called drug-drug-gene interactions (DDGI), will improve treatment success. This study aims to design a relational database named DDGICat, which was designed to contribute to the ongoing DDGI research by serving as a guideline to prescribers, researchers, and the pharmaceutical industry. The content of the DDGICat was derived from other knowledge bases, including DrugBank, PharmGKB, Ensembl, KEGG Drug, and ONC High. DDGICat contains drugs, drug target proteins, drug-associated SNPs, DDIs, drug-gene interactions (DGIs), and DDGIs. Additionally, a developed web portal named DDGICat Browser provides the results of mentioned content in both tabular and graphical formats. Furthermore, the end products of this study are tested in a case study on a chosen disease.

Subject Keywords

drug-drug interaction, drug-gene interaction, drug-drug-gene interaction, database, Single Nucleotide Polymorphism

URI

https://hdl.handle.net/11511/92240

Collections

Graduate School of Informatics, Thesis

Suggestions

OpenMETU
Core

Effect of cobalt-60 (gamma radiation) on multidrug-resistant multiple myeloma cell lines Mutlu, Pelin; Ural, A. Ugur; Avcu, Ferit; Dirican, Bahar; Beyzadeoglu, Murat; Gündüz, Ufuk (2011-07-01) Emergence of resistance to chemotherapy and radiotherapy is a major obstacle for the successful treatment of MM (multiple myeloma). Prednisone, vincristine and melphalan are commonly used chemotherapeutic agents for the treatment of MM. In the current study, we examined the presence of possible cross-resistance between these drugs and gamma (gamma) radiation. Prednisone, vincristine and melphalan resistant RPMI-8226 and U-266 MM cells were generated by stepwise increasing concentrations of the drugs. The se...
Development and characterization of cortisone derivative drugcarrying polymeric microspheres Öcal, Yiğit; Keskin, Dilek; Özen, Seza; Department of Biomedical Engineering (2011) In this study, it is aimed to develop an injectable controlled release system of PCL and P(L,DL)LA microspheres loaded with TA and/or Ral for local treatment of rheumatoid arthritis which will avoid from systemic side effects of traditional administration and eliminate problems caused by direct local injections. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder that most commonly causes inflammation and tissue damage in joints and tendon sheaths. Current strategies for the disease are ma...
INVESTIGATION OF CLONAL EVOLUTION IN CAPECITABINE RESISTANT CACO-2 AND IRINOTECAN RESISTANT HT-29 CELL LINES BY USING CELLULAR BARCODING TECHNOLOGY Danışık, Nurseda; Acar, Ahmet; Özen, Can; Department of Biotechnology (2022-10-31) The development of drug resistance in tumor cells is one of the biggest problems currently in the clinic. As the pace of drug discovery slows and each new drug becomes increasingly expensive to bring to market, it is becoming clearer that better model systems and an understanding of drug resistance mechanisms are needed for second-line therapies. The overall aim of this project is to investigate the clonal evolution and drug resistance in colorectal cancer cell lines Caco-2 and HT-29 by using cellular barco...
In Situ, In Vitro and In Vivo evaluation of effectiveness of new treatment approaches involving controlled drug delivery systems in cartilage degenerations Aydın, Özlem; Keskin, Dilek; Tezcaner, Ayşen; Department of Engineering Sciences (2011) Osteoarthritis (OA) is a degenerative joint disease which has yet no complete treatment with medication. Doxycycline, a well-known antibiotic, has been shown to prevent matrixmetallopreoteinases-MMPs, indicating potency on OA treatment. However, long term systemic use can cause side effects on other tissues. This study aimed to develop controlled drug delivery systems of doxycycline/doxycycline-chondroitin sulfate (D/D-CS) in the form of PCL microspheres for providing a better and new treatment approach via...
Genomic characterization of pseudomonas aeruginosa clinical isolates by pulsed field gel electrophoresis method Alipour Ghorbani, Nader; Yıldız, Fatih; Durmaz, Rıza; Department of Biotechnology (2014) Pseudomonas aeruginosa is a common cause of nosocomial infections, particularly in intensive care units (ICUs), bronchoscopy, oncology, and urology. The aim of this study was to characterize P. aeruginosa clinical isolates clonally relatedness by pulsed-field gel electrophoresis (PFGE) typing and it’s cut off value determination. We did retrospective study and analyzed genotypically a collection of 58 clinical isolates recovered during the period 2006–2011 from MESA private hospital microbiology department’...

Citation Formats

A. OZDEMIR, “GENOTYPE CATALOG FOR THE ANALYSIS OF DRUG-DRUG INTERACTIONS,” M.S. - Master of Science, Middle East Technical University, 2021.