Boron doped hydroxyapatites in biomedical applications

Uysal, İdil
Yılmaz, Bengi
Evis, Zafer
Hydroxyapatite has been widely used in biomedical applications as a coatingmaterial for implant surfaces, a drug carrier, a scaffold or composite for bonetissue engineering applications. The highly ionic structure of hydroxyapatite allowsdoping of various ions, resulting in an improvement in its properties. Boron is oneof the elements which can be doped into hydroxyapatite structure by replacingphosphate (PO43-) or hydroxyl (OH-) sites to obtain scaffolds for bone tissueengineering applications or a coating material for metal substrates. Although theeffects of supplemental boron on bone, liver, and brain metabolism have beenshown to have important results as a nutrient, there are very few studies in theliterature on the use of boron-doped hydroxyapatite in the biomedical field. In thisreview, the details of synthesis methods and functional groups of boron-dopedhydroxyapatite were tabulated. Generally, the addition of boron leads to theformation of rod-like morphology, while the density and Vicker’s microhardnessof hydroxyapatite decrease. Thermal stability and electrical insulation propertieswere observed to improve with boron doping. Boron was also shown to increasebiodegradability, bioactivity as well as cell proliferation and differentiation ofdifferent cell types on the surface of hydroxyapatite.
Bor Dergisi


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Citation Formats
İ. Uysal, B. Yılmaz, and Z. Evis, “Boron doped hydroxyapatites in biomedical applications,” Bor Dergisi, vol. 5, no. 4, pp. 199–208, 2020, Accessed: 00, 2021. [Online]. Available: