Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Boron nitride nanofiber/Zn-doped hydroxyapatite/polycaprolactone scaffolds for bone tissue engineering applications
Date
2023-05-01
Author
Turhan, Emine Ayşe
Akbaba, Sema
Tezcaner, Ayşen
Evis, Zafer
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
203
views
0
downloads
Cite This
In this study, Zn doped hydroxyapatite (Zn HA)/boron nitride nanofiber (BNNF)/poly-ε-caprolactone (PCL) composite aligned fibrous scaffolds are produced with rotary jet spinning (RJS) for bone tissue engineering applications. It is hypothesized that addition of Zn HA and BNNF will contribute to cell viability as well as mechanical and osteogenic properties of the PCL scaffolds. Zn HA was synthesized by mixing Ca and P sources followed by sonication and aging whereas BNNF was obtained by the reaction of melamine with boric acid followed by freeze-drying for annealing of fibers. It is found that incorporation of both Zn HA and BNNF in PCL fibers resulted in higher calcium phosphate (CaP) precipitation on the scaffolds. Also, in vitro cell culture studies showed that presence of both Zn HA and BNNF also had synergistic effect for enhanced proliferation and osteogenic activity of Saos-2 cells. Mechanical properties of PCL-Zn HA-BNNF were found similar to that of non-load bearing bones. Furthermore, the presence of Zn HA and BNNF had synergistic effects to cell attachment, proliferation and spreading without causing cytotoxic effect on cells. The highest ALP activity was obtained in the PCL-Zn HA- BNNF group at days 7 and 14 due to release of zinc, calcium, phosphate and boron. Considering its mechanical and bioactivity properties, PCL-Zn HA-BNNF composite scaffolds hold promise as non-load bearing bone substitutes.
Subject Keywords
Bone tissue engineering
,
Boron nitride nanofiber
,
Hydroxyapatite
,
PCL
,
Rotary jet spinning
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150459745&origin=inward
https://hdl.handle.net/11511/102625
Journal
Biomaterials Advances
DOI
https://doi.org/10.1016/j.bioadv.2023.213382
Collections
Department of Engineering Sciences, Article
Suggestions
OpenMETU
Core
Silicate-doped nano-hydroxyapatite/graphene oxide composite reinforced fibrous scaffolds for bone tissue engineering
Dalgıç, Ali Deniz; Tezcaner, Ayşen; Keskin, Dilek; Evis, Zafer (SAGE Publications, 2018-3-15)
In this study, novel graphene oxide-incorporated silicate-doped nano-hydroxyapatite composites were prepared and their potential use for bone tissue engineering was investigated by developing an electrospun poly(epsilon-caprolactone) scaffold. Nanocomposite groups were synthesized to have two different ratios of graphene oxide (2 and 4 wt%) to evaluate the effect of graphene oxide incorporation and groups with different silicate-doped nano-hydroxyapatite content was prepared to investigate optimum concentra...
Boron doped hydroxyapatites in biomedical applications
Uysal, İdil; Yılmaz, Bengi; Evis, Zafer (2020-12-01)
Hydroxyapatite has been widely used in biomedical applications as a coatingmaterial for implant surfaces, a drug carrier, a scaffold or composite for bonetissue engineering applications. The highly ionic structure of hydroxyapatite allowsdoping of various ions, resulting in an improvement in its properties. Boron is oneof the elements which can be doped into hydroxyapatite structure by replacingphosphate (PO43-) or hydroxyl (OH-) sites to obtain scaffolds for bone tissueengineering applications or a coating...
3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering
Jodati, Hossein; Evis, Zafer; Tezcaner, Ayşen; Alshemary, Ammar Z.; Motameni, Ali (2023-04-01)
Making composite scaffolds is one of the well-known methods to improve the properties of scaffolds used in bone tissue engineering. In this study, novel ceramic-based 3D porous composite scaffolds were successfully prepared using boron-doped hydroxyapatite, as the primary component, and baghdadite, as the secondary component. The effects of making composites on the properties of boron-doped hydroxyapatite-based scaffolds were investigated in terms of physicochemical, mechanical, and biological properties. T...
Boron nitride/zinc doped hydroxyapatite/polycaprolactone composite scaffolds for bone tissue engineering
Turhan, Emine Ayşe; Evis, Zafer; Tezcaner, Ayşen; Department of Micro and Nanotechnology (2021-3)
Bone diseases and disorders have been expected to increase mostly in time because of the aging, obesity and pysical activity problems. For this reason, bone tissue engineering has been focus point to design new biocompatible scaffolds and enhance bone tissue regeneration. Composite scaffolds composed of PCL, Zn doped hydoxyapatite (HA), and boron nitride nanofibers (BNNFs) were prepared by the rotary jet spinning for bone tissue engineering applications. Synthesis of BNNFs and Zn-HA was achieved by the free...
Boron-doped Biphasic Hydroxyapatite/beta-Tricalcium Phosphate for Bone Tissue Engineering
Pazarçeviren, Ahmet Engin; Tezcaner, Ayşen; Keskin, Dilek; Evis, Zafer (Springer Science and Business Media LLC, 2020-06-10)
Boron-doped hydroxyapatite/tricalcium phosphates (BHTs) were synthesized to study boron uptake and correlate structural alterations of incremental boron addition (0 to 10 mol%). BHTs with a Ca/P ratio of 1.6 were prepared by a wet precipitation/microwave reflux method, sieved (< 70 mu m) and characterized. XRD and FTIR analyses revealed that boron slightly distorted apatite crystal, increased crystallinity (95.78 +/- 2.08% for 5BHT) and crystallite size (103.39 +/- 23.47 nm for 5BHT) and still, boron additi...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
E. A. Turhan, S. Akbaba, A. Tezcaner, and Z. Evis, “Boron nitride nanofiber/Zn-doped hydroxyapatite/polycaprolactone scaffolds for bone tissue engineering applications,”
Biomaterials Advances
, vol. 148, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150459745&origin=inward.