Boron Cage Triggered Micellization of a Neutral-Cationic Block Copolymer and Preparation of Boron-Containing Layer-by-Layer Microparticles

2022-01-01
Aydemir, Umut
Ugur, Esma
Ermis, Cagdas
Aydemir, Fatma Nur
Ozdemir, Erhan
Banerjee, Sreeparna
Yıldırım, Erol
Akdağ, Akın
Erel Göktepe, İrem
© 2022 American Chemical Society. All rights reserved.The preparation of a polymer carrier for a boron delivery agent is presented through a combination of experimental and computational studies. A dodecahydro-closo-dodecaborate (B12H12)2- (B12) anion was used as a model boron-containing agent due to its high boron content. Quaternized poly(2-vinyl pyridine)-b-poly(ethylene oxide) (QP2VP-b-PEO) was chosen as a model neutral-cationic block copolymer to construct the carrier. The electrostatic association between QP2VP and B12 induced the self-assembly of QP2VP-b-PEO, resulting in micelles with (B12 + QP2VP)-core and PEO-corona. The mechanism of formation of (B12 + QP2VP)-b-PEO micelles was examined through density functional theory (DFT) calculations and classical simulations. (B12 + QP2VP)-b-PEO micelles were found to be undurable in biological medium. To enhance stability, micelles were utilized as building blocks together with poly(N-vinyl caprolactam) (PVCL) and tannic acid (TA) to construct layer-by-layer (LbL) microparticles. Cytotoxicity and cellular association of LbL particles were assessed using the HepG2 cell line. Multilayered particles were found to show no cellular cytotoxicity. Association studies and the boron content of treated cells through inductively coupled plasma optical emission spectroscopy (ICP-OES) showed that LbL microparticles were extensively associated with and successfully delivered boron to HepG2 cells. This study reveals the challenges and possible solutions to obtain stable self-assembled structures in a cell culture medium. These findings contribute to a fundamental understanding of the structure-property relationship in self-assembled micelles/LbL particles and provide a basis for further development of boron-containing polymer vehicles for boron neutron capture therapy.
ACS Applied Polymer Materials

Suggestions

Synthesis of a Novel and More Sustainable Cationic Bleach Activator, N-[4-(N, N, N)-Triethylammoniumchloride-butanoyl] Butyrolactam, for Cotton: Optimization and Theoretical Limitations
Altay, Pelin; Yıldırım, Erol; Gürsoy, Nevin Çiğdem; Hauser, Peter J.; El-Shafei, Ahmed (2022-04-11)
© 2022 American Chemical Society. All rights reserved.Activated bleach systems have the potential to produce more efficient kinetically potent bleaching systems through increased oxidation rates with reduced energy cost and less time, hence causing less cellulose polymer chain damage or degradation than conventional hot peroxide bleaching. This article presents a study at the molecular level of a novel and more sustainable cationic bleach activator for cotton than aromatic-based cationic bleach activators u...
Simultaneous Crystallization and Strain Induction Enable Light-Emitting Germanium Nano/Microbridges for Infrared Lasers
Unlu, Buse; Ghasemi, Milad; Yerci, Selçuk; Boztug, Cicek (2022-04-22)
© 2022 American Chemical Society. All rights reserved.Tensilely strained germanium has been considered a suitable material platform for the realization of a monolithically integrated infrared laser that could allow the development of miniaturized photonic integrated circuits. The crystalline quality of germanium is one of the concerns in this regard since it has to be in the high-quality single-crystal form to endure the required amounts of tensile strain so that the material turns into a gain medium. For t...
Plasmonic light-management interfaces by polyol-synthesized silver nanoparticles for industrial scale silicon solar cells
Birant, Gizem; Öztürk, İbrahim Murat; Doğanay, Doğa; Ünalan, Hüsnü Emrah; Bek, Alpan (2020-01-01)
© 2020 American Chemical Society. All rights reserved.Plasmonic interfaces are used as an alternative and highly effective light management technique for solar cells. Topdown approaches produce well-ordered and carefully designed plasmonic structures for tailor-made light management; however, they are costly, and their fabrication is time-consuming. Thus, their utilization for industrial-scale solar cells is not trivial. It has been shown that dewetting is a cost- and time-effective bottom-up approach for t...
Bacterial anti-adhesive and pH-induced antibacterial agent releasing ultra-thin films of zwitterionic copolymer micelles
Onat, Bora; Butun, Vural; Banerjee, Sreeparna; Erel Göktepe, İrem (2016-08-01)
We report on preparation of substrates with dual function coatings, i.e. bacterial anti-adhesive and antibacterial agent releasing polymer films of zwitterionic block copolymer micelles (BCMs). BCMs were obtained by pH-induced self-assembly of poly[3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate-b-2-(diisopropylamino)ethyl methacrylate] (beta PDMA-b-PDPA), resulting in BCMs with zwitterionic beta PDMA-coronae and pH-responsive PDPA-core. These zwitterionic BCMs were then used as building blocks...
Boron coating on boron nitride coated nuclear fuels by chemical vapor deposition
Durmazucar, HH; Gündüz, Güngör (2000-12-01)
Uranium dioxide-only and uranium dioxide-gadolinium oxide (5% and 10%) ceramic nuclear fuel pellets which were already coated with boron nitride were coated with thin boron layer by chemical vapor deposition to increase the burnup efficiency of the fuel during reactor operation. Coating was accomplished from the reaction of boron trichloride with hydrogen at 1250 K in a tube furnace, and then sintering at 1400 and 1525 K. The deposited boron was identified by infrared spectrum. The morphology of the coating...
Citation Formats
U. Aydemir et al., “Boron Cage Triggered Micellization of a Neutral-Cationic Block Copolymer and Preparation of Boron-Containing Layer-by-Layer Microparticles,” ACS Applied Polymer Materials, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/97626.