Boron Cage Triggered Micellization of a Neutral-Cationic Block Copolymer and Preparation of Boron-Containing Layer-by-Layer Microparticles

2022-01-01
Aydemir, Umut
Ugur, Esma
Ermis, Cagdas
Aydemir, Fatma Nur
Ozdemir, Erhan
Banerjee, Sreeparna
Yıldırım, Erol
Akdağ, Akın
Erel Göktepe, İrem
© 2022 American Chemical Society. All rights reserved.The preparation of a polymer carrier for a boron delivery agent is presented through a combination of experimental and computational studies. A dodecahydro-closo-dodecaborate (B12H12)2- (B12) anion was used as a model boron-containing agent due to its high boron content. Quaternized poly(2-vinyl pyridine)-b-poly(ethylene oxide) (QP2VP-b-PEO) was chosen as a model neutral-cationic block copolymer to construct the carrier. The electrostatic association between QP2VP and B12 induced the self-assembly of QP2VP-b-PEO, resulting in micelles with (B12 + QP2VP)-core and PEO-corona. The mechanism of formation of (B12 + QP2VP)-b-PEO micelles was examined through density functional theory (DFT) calculations and classical simulations. (B12 + QP2VP)-b-PEO micelles were found to be undurable in biological medium. To enhance stability, micelles were utilized as building blocks together with poly(N-vinyl caprolactam) (PVCL) and tannic acid (TA) to construct layer-by-layer (LbL) microparticles. Cytotoxicity and cellular association of LbL particles were assessed using the HepG2 cell line. Multilayered particles were found to show no cellular cytotoxicity. Association studies and the boron content of treated cells through inductively coupled plasma optical emission spectroscopy (ICP-OES) showed that LbL microparticles were extensively associated with and successfully delivered boron to HepG2 cells. This study reveals the challenges and possible solutions to obtain stable self-assembled structures in a cell culture medium. These findings contribute to a fundamental understanding of the structure-property relationship in self-assembled micelles/LbL particles and provide a basis for further development of boron-containing polymer vehicles for boron neutron capture therapy.
ACS Applied Polymer Materials

Suggestions

Synthesis of a Novel and More Sustainable Cationic Bleach Activator, N-[4-(N, N, N)-Triethylammoniumchloride-butanoyl] Butyrolactam, for Cotton: Optimization and Theoretical Limitations
Altay, Pelin; Yıldırım, Erol; Gürsoy, Nevin Çiğdem; Hauser, Peter J.; El-Shafei, Ahmed (2022-04-11)
© 2022 American Chemical Society. All rights reserved.Activated bleach systems have the potential to produce more efficient kinetically potent bleaching systems through increased oxidation rates with reduced energy cost and less time, hence causing less cellulose polymer chain damage or degradation than conventional hot peroxide bleaching. This article presents a study at the molecular level of a novel and more sustainable cationic bleach activator for cotton than aromatic-based cationic bleach activators u...
Versatile-in-All-Trades: Multifunctional Boron-Doped Calcium-Deficient Hydroxyapatite Directs Immunomodulation and Regeneration
Pazarçeviren, Ahmet Engin; Akbaba, Sema; Evis, Zafer; Tezcaner, Ayşen (2022-07-11)
© 2022 American Chemical Society. All rights reserved.Osseointegration of implants depends on several intertwined factors: osteogenesis, angiogenesis, and immunomodulation. Lately, novel reinforcements allowing faster bonding with osseous tissue have been explored intensively. In this study, we hypothesized the use of boron as a major multifunctional ion to confer versatility to calcium-deficient hydroxyapatite (cHA) synthesized by a wet precipitation/microwave reflux method. By synthesis of boron-doped cal...
Simultaneous Crystallization and Strain Induction Enable Light-Emitting Germanium Nano/Microbridges for Infrared Lasers
Unlu, Buse; Ghasemi, Milad; Yerci, Selçuk; Boztug, Cicek (2022-04-22)
© 2022 American Chemical Society. All rights reserved.Tensilely strained germanium has been considered a suitable material platform for the realization of a monolithically integrated infrared laser that could allow the development of miniaturized photonic integrated circuits. The crystalline quality of germanium is one of the concerns in this regard since it has to be in the high-quality single-crystal form to endure the required amounts of tensile strain so that the material turns into a gain medium. For t...
Differential Behavior of Metal Sulfides in Hydrothermal Plumes and Diffuse Flows
Estes, Emily R.; Berti, Debora; Findlay, Alyssa J.; Hochella, Michael F.; Shaw, Timothy J.; Yücel, Mustafa; De Carlo, Eric H.; Luther, George W. (2022-06-16)
© 2022 American Chemical Society. All rights reserved.Extensive sampling of high-Temperature hydrothermal fluids and diffuse flows within <2 m of the vent orifices at the 9°50′N East Pacific Rise (EPR) hydrothermal vent field reveals formation of nanoparticulate phases and rapid precipitation/aggregation of metal sulfide minerals upon mixing of vent fluid with ambient seawater. Here, we characterize metal sulfide phases via scanning and transmission electron microscopy (SEM, TEM) in addition to quantifying ...
Plasmonic light-management interfaces by polyol-synthesized silver nanoparticles for industrial scale silicon solar cells
Birant, Gizem; Öztürk, İbrahim Murat; Doğanay, Doğa; Ünalan, Hüsnü Emrah; Bek, Alpan (2020-01-01)
© 2020 American Chemical Society. All rights reserved.Plasmonic interfaces are used as an alternative and highly effective light management technique for solar cells. Topdown approaches produce well-ordered and carefully designed plasmonic structures for tailor-made light management; however, they are costly, and their fabrication is time-consuming. Thus, their utilization for industrial-scale solar cells is not trivial. It has been shown that dewetting is a cost- and time-effective bottom-up approach for t...
Citation Formats
U. Aydemir et al., “Boron Cage Triggered Micellization of a Neutral-Cationic Block Copolymer and Preparation of Boron-Containing Layer-by-Layer Microparticles,” ACS Applied Polymer Materials, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/97626.