Antibody response of sheep to simultaneous vaccination of foot-and-mouth disease, peste des petits ruminants, sheep pox and goat pox, and bluetongue vaccines

Date

2022-03-01

Author

Sareyyüpoǧlu, B.
Gülyaz, G.
Saraç, F.
Uzar, S.
Kabakl, Ö.
Çokçalşkan, C.
Gündüzalp, C.
Uzun, E.A.
Çamlı, Onur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

228
views

0
downloads

There are many infectious animal diseases in Turkey and generally, vaccination is the primarly control strategy to combat them. However, it is difficult to apply all vaccines in a definite peri od i n the fi el d due to l i mi tati ons of the l abor and fi nance. Rapi d vacci nati on and effective use of labor can be possible with the help of simultaneous vaccine administrations. The study aims to show the effects of simultaneous foot-and-mouth disease (FMD), peste des petits ruminants (PPR), sheep pox and goat pox (SGP), and bluetongue (BT) vaccine administration on the antibody response of sheep. For this aim, 30 sheep were divided into one experiment and 5 control groups. Blood samples were collected in each group at 0, 30 and 60 days post-vaccination (DPV). Immune response was measured with virus neutralization test (VNT) and, liquid phase blocking ELISA (LPBE) for FMDV; VNT for BTV and PPR. A live virus challenge study was performed to determine the immune response of SGP vaccine. As a result, antibody titers for each vaccine agent decreased on 60 DPV with the simultaneous vaccination except FMD. The difference between means of antibody titer decrease with single and simultaneous vaccinations is significant especially for BTV and PPR vaccines at 60DPV (p<0.05). Bri efl y, thi s decreasi ng i mmune response of three l i ve vacci nes can be explained with the development of the interference, administration of these vaccines from the same injection site, the effect of cytokines, especially IL-10 effect of SGP vaccine. It was concluded that four vaccines can not be used simultaneously in sheep.

Subject Keywords

Antibody response, sheep, simultaneous, vaccination, viruses

URI

https://hdl.handle.net/11511/97731

Journal

Tropical Biomedicine

DOI

https://doi.org/10.47665/tb.39.1.002

Collections

Department of Statistics, Article

Suggestions

OpenMETU
Core

Surveillance of prion protein (PrP9 gene polymorphisms in Turkish native sheep breeds Uzun, Begüm; Togan, İnci Zehra; Department of Biology (2012) Scrapie is an infectious fatal disease of sheep and goats which affects the central nervous system. In the present study, samples of 14 native Turkish sheep breeds (n=655) were analyzed with respect to their polymorphisms of PrP gene (at codons: 136, 141, 154 and 171) and their classical and atypical scrapie risk levels were identified. Turkish sheep are found to have the highest PrP genetic variability with 13 classical scrapie alleles and 14 atypical scrapie alleles compared to all previous studies. Class...
Immunoproteomic analysis of Bordetella pertussis and identification of new immunogenic proteins Altindis, Emrah; Tefon, Burcu E.; Yildirim, Volkan; Ozcengiz, Erkan; Becher, Doete; Hecker, Michael; Özcengiz, Gülay (Elsevier BV, 2009-01-22) Bordetella pertussis is the causative agent of highly communicable respiratory infection whooping cough (pertussis) which remains one of the world's leading causes of vaccine-preventable deaths. In the present study, total soluble proteins extracted from two B. pertussis strains, Tohama I and the local isolate Saadet were separated by two-dimensional gel electrophoresis and analyzed by Western blotting for their reactivity with the antisera obtained from the mice immunized with inactivated whole cells as we...
PRODUCTION OF VIRUS LIKE PARTICLES EXPRESSING ALPHA (B.1.1.7) OR DELTA PLUS (B.1.617.2.1) SPIKE VARIANTS AND DEVELOPMENT OF A PSEUDOTYPED VIRUS NEUTRALIZATION ASSAY Güvençli, Neşe; Gürsel, Mayda; Department of Molecular Biology and Genetics (2022-2-10) Vaccines are one of the most important public health interventions to combat the spread of infectious diseases. All currently approved COVID-19 vaccines target Spike antigen derived from the authentic Wuhan strain. However, with the emergence of new variants effectiveness of the current vaccines declined, commensurate to their ability to generate neutralizing antibodies against some variants of concern (VOC). Since new VOCs are predicted to emerge the next 2-4 years, variant specific vaccines are urgently n...
Development of rapid dipstick assay for food pathogens, Salmonella, by optimized parameters Çam, Dilek; Öktem, Hüseyin Avni (Springer Science and Business Media LLC, 2018-10-25) Salmonella is among the very important pathogens threating the human and animal health. Rapid and easy detection of these pathogens is crucial. In this context, antibody (Ab) based lateral flow assays (LFAs) which are simple immunochromatographic point of care test kits were developed by gold nanoparticles (GNPs) as labelling agent for Salmonella detection. For that purpose some critical parameters such as reagent concentrations on the capture zones, conjugate concentrations and ideal membrane type needed f...
Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes Soyer, Yeşim; Rodriguez-Rivera, Lorraine D.; Sun, Qi; Wiedmann, Martin (Springer Science and Business Media LLC, 2009-11-14) Background: The bacterium Salmonella enterica includes a diversity of serotypes that cause disease in humans and different animal species. Some Salmonella serotypes show a broad host range, some are host restricted and exclusively associated with one particular host, and some are associated with one particular host species, but able to cause disease in other host species and are thus considered "host adapted". Five Salmonella genome sequences, representing a broad host range serotype (Typhimurium), two host...

Citation Formats

B. Sareyyüpoǧlu et al., “Antibody response of sheep to simultaneous vaccination of foot-and-mouth disease, peste des petits ruminants, sheep pox and goat pox, and bluetongue vaccines,” Tropical Biomedicine, vol. 39, no. 1, pp. 47–54, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/97731.