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Rapid diagnosis of malignant pleural mesothelioma and its discrimination from lung cancer and benign exudative effusions using blood serum
Date
2022-10-01
Author
Yonar, Dilek
Severcan, Mete
Gurbanov, Rafig
Sandal, Abdulsamet
Yilmaz, Ulku
Emri, Salih
Severcan, Feride
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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© 2022Malignant pleural mesothelioma (MPM), an aggressive cancer associated with exposure to fibrous minerals, can only be diagnosed in the advanced stage because its early symptoms are also connected with other respiratory diseases. Hence, understanding the molecular mechanism and the discrimination of MPM from other lung diseases at an early stage is important to apply effective treatment strategies and for the increase in survival rate. This study aims to develop a new approach for characterization and diagnosis of MPM among lung diseases from serum by Fourier transform infrared spectroscopy (FTIR) coupled with multivariate analysis. The detailed spectral characterization studies indicated the changes in lipid biosynthesis and nucleic acids levels in the malignant serum samples. Furthermore, the results showed that healthy, benign exudative effusion, lung cancer, and MPM groups were successfully separated from each other by applying principal component analysis (PCA), support vector machine (SVM), and especially linear discriminant analysis (LDA) to infrared spectra.
Subject Keywords
Mesothelioma
,
Lung cancer
,
Blood serum
,
Spectral biomarkers
,
ATR-FTIR spectroscopy
,
Multivariate analysis
,
TRANSFORM-INFRARED-SPECTROSCOPY
,
ATR-FTIR SPECTROSCOPY
,
BLADDER-CANCER
,
MICROSPECTROSCOPY
,
BIOMARKER
,
TISSUES
,
SAMPLES
,
DISEASE
,
METABOLISM
,
MICROSCOPY
,
ATR-FTIR spectroscopy
,
Blood serum
,
Lung cancer
,
Mesothelioma
,
Multivariate analysis
,
Spectral biomarkers
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85132845226&origin=inward
https://hdl.handle.net/11511/98979
Journal
Biochimica et Biophysica Acta - Molecular Basis of Disease
DOI
https://doi.org/10.1016/j.bbadis.2022.166473
Collections
Department of Biology, Article
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D. Yonar et al., “Rapid diagnosis of malignant pleural mesothelioma and its discrimination from lung cancer and benign exudative effusions using blood serum,”
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol. 1868, no. 10, pp. 0–0, 2022, Accessed: 00, 2022. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85132845226&origin=inward.