Evaluation of disseminated candidiasis on an experimental animal model: A Fourier transform infrared study

Date

2007-02-01

Author

Dogan, Ayca
Ergen, Kivanc
Budak, Fatma
Severcan, Feride

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Invasive candidiasis, defined as candidemia and disseminated candidiasis, is the most common fungal infection in hospitalized patients. In the current study, we used Fourier transform infrared (FT-IR) spectroscopy as a rapid, non-perturbing technique to investigate the effects of disseminated candidiasis on mouse liver tissues at the molecular level. The results revealed that the infection caused compositional changes in the tissues by decreasing the lipid content and the ratio of the saturated lipids to unsaturated lipids. An increase in the lipid/protein ratio was also observed. In addition, investigation of the olefinic band at 3014 cm(-1), showed that lipid peroxidation took place in the infected samples. These results indicate that FT-IR spectroscopy is a promising technique for the evaluation and diagnosis of disseminated candidiasis.

Subject Keywords

Instrumentation, Spectroscopy

URI

https://hdl.handle.net/11511/57135

Journal

APPLIED SPECTROSCOPY

DOI

https://doi.org/10.1366/000370207779947459

Collections

Department of Biology, Article

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Citation Formats

A. Dogan, K. Ergen, F. Budak, and F. Severcan, “Evaluation of disseminated candidiasis on an experimental animal model: A Fourier transform infrared study,” APPLIED SPECTROSCOPY, pp. 199–203, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57135.