Synthesis of New Squaramide Based Organocatalyst and Its Application for Enantioselective Synthesis of Organic Compounds

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Özge Özdemir Master Tez.pdf

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2022-9-19

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Özdemir, Özge

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Organocatalytic asymmetric synthesis of organic compounds is one of the important fields of synthetic organic chemistry. Organocatalysts are small chiral organic molecules having certain functional groups, such as hydroxy, amino, amido etc. These catalysts are environmentally more friendly than the alternative chiral metal catalysts. Therefore, they are more popular and studied more than the metal catalysts. On the other hand, there are no organocatalysts that work well for every organic reaction. Here in thesis, we wanted to design and synthesize new squaramide based chiral organocatalyst starting with previously developed ferrocenyl aziridinyl methanol which in few steps is converted to amine and reacted with squarate. Additionally, we aimed to apply organocatalyst to the enantioselective synthesis of organic compounds.

Subject Keywords

Squaramide organocatalyst, 1,3-diketones, nitroolefins, Michael reaction

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https://hdl.handle.net/11511/99414

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

Ö. Özdemir, “Synthesis of New Squaramide Based Organocatalyst and Its Application for Enantioselective Synthesis of Organic Compounds,” M.S. - Master of Science, Middle East Technical University, 2022.