Synthesis of New Squaramide Based Organocatalyst and Its Application for Enantioselective Synthesis of Organic Compounds

2022-9-19
Özdemir, Özge
Organocatalytic asymmetric synthesis of organic compounds is one of the important fields of synthetic organic chemistry. Organocatalysts are small chiral organic molecules having certain functional groups, such as hydroxy, amino, amido etc. These catalysts are environmentally more friendly than the alternative chiral metal catalysts. Therefore, they are more popular and studied more than the metal catalysts. On the other hand, there are no organocatalysts that work well for every organic reaction. Here in thesis, we wanted to design and synthesize new squaramide based chiral organocatalyst starting with previously developed ferrocenyl aziridinyl methanol which in few steps is converted to amine and reacted with squarate. Additionally, we aimed to apply organocatalyst to the enantioselective synthesis of organic compounds.

Suggestions

Synthesis of 2,3-disubstituted thiophenes from ketoalkynes
Vatansever, Erol Can; Balcı, Metin; Department of Chemistry (2013)
Synthesis of thiophene containing compounds are of particular interest in synthetic organic chemistry. Besides the importance for synthetic organic chemistry, thiophene derivatives are used in applied research such as drug synthesis and study of functional materials. In this thesis, a new methodology for developing of 2,3-disubstituted thiophenes was developed. This methodology utilizes readily available compounds in a two-step synthesis to provide a facile access to the 2,3-disubstituted thiophenes. In the...
SYNTHESİS OF NEW PHOSPHONİC ACİD DRİVATİVES AND THEIR USE AS AN ORGANOCATALYSTS FOR ENANTİOSELECTİVE SYNTHESIS OF ORGANIC COMPOUNDS
Doğan, Özdemir(2017-12-31)
SYNTHESİS OF NEW PHOSPHONİC ACİD DRİVATİVES AND THEIR USE AS AN ORGANOCATALYSTS FOR ENANTİOSELECTİVE SYNTHESIS OF ORGANIC COMPOUNDS
Synthesis of Functionalized Novel alpha-Amino-beta-alkoxyphosphonates through Regioselective Ring Opening of Aziridine-2-phosphonates
Polat-Cakir, Sidika; Beksultanova, Nurzhan; Doğan, Özdemir (Wiley, 2019-11-01)
Aziridines are highly useful compounds as building blocks for the synthesis of important organic compounds. Amino acid synthesis by aziridine ring opening reaction is a good example to the use of aziridines. Although this reaction is studied by many groups, the synthesis of amino phosphonic acids is less explored. In this study, we have carried out the ring opening reaction of aziridinyl phosphonates with a variety of alcohols including the more functional propargylic and allylic alcohols. These reactions p...
Synthesis of Bishomoinositols and an Entry for Construction of a Substituted 3-Oxabicyclo[3.3.1]nonane Skeleton
BARAN, ARİF; Bekarlar, Merve; Aydin, Gokay; NEBİOĞLU, MEHMET; ŞAHİN, Ertan; Balcı, Metin (2012-02-03)
1,3,3a,7a-Tetrahydro-2-benzofuran was used as key compound for the synthesis of various bishomoinositol derivatives. The diene was subjected to an epoxidation reaction for further functionalization of the diene unit. The bisepoxide obtained was submitted to a ring-opening reaction with acid in the presence of water. Various bishomoinositols were synthesized. However, when the reaction was carried out in the presence of acetic anhydride, a substituted 3-oxabicyclo[3.3.1]nonane skeleton was formed. The mechan...
Synthesis of new pyrrole derivatives from npropargylic β-enaminones
Kanova, Nilay; Zora, Metin; Department of Chemistry (2020)
Heterocyclic compounds are a momentous area of synthetic organic chemistry because of their existence in bioactive molecules. Pyrroles, which are one of the most important classes of heterocyclic compounds, have great importance in pharmaceutical chemistry due to their biological activities. Having these characteristics makes them drawn attention of most chemists to develop new methodologies for the synthesis of pyrroles. Recently, the cyclization of Npropargylic β-enaminones has been used for the synthesis...
Citation Formats
Ö. Özdemir, “Synthesis of New Squaramide Based Organocatalyst and Its Application for Enantioselective Synthesis of Organic Compounds,” M.S. - Master of Science, Middle East Technical University, 2022.