Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Synthesis of baghdadite using modified sol–gel route and investigation of its properties for bone treatment applications
Date
2022-01-01
Author
Jodati, Hossein
Tezcaner, Ayşen
Evis, Zafer
Alshemary, Ammar Z
ÇELİK, ERDAL
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
143
views
0
downloads
Cite This
The requirement for biomaterials with superior properties, used in bone treatment applications, is inevitable due to escalated bone tissue defects. Baghdadite (BAG) is a calcium silicate that benefits from the presence of zirconium (Zr) in its structure and has attracted huge attention in recent years. In this study, a modified sol–gel route was proposed to synthesize BAG by dissolving Zr precursor separately and using optimum amounts of solvent and chelating agent. Due to thermal gravimetric analysis and differential thermal analysis (TGA–DTA), X-ray diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FTIR) results, the BAG nanoparticles were successfully synthesized using this modified approach for the first time, and they were comprehensively characterized in terms of physicochemical, mechanical, and biological properties. During synthesis, a transparent sol without any insoluble Ca or Zr precursors and/or no premature gelation was observed, unlike samples that we produced using the conventional sol–gel method in the literature. The crystalline BAG nanoparticles with semi-spherical shapes demonstrated ~ 20% weight loss after 28 days during the biodegradability test, extensive bioactivity, and enhanced mechanical strength (~4 MPa). Moreover, BAG powder was biocompatible with no cytotoxic effect and osteoinductive in the absence of an osteogenic medium. We believe that the synthesized BAG nanoparticles through this modified sol–gel route could serve as a promising biomaterial for cancellous bone defect treatment applications.
Subject Keywords
Baghdadite
,
Bioceramic
,
Bone
,
Sol–gel
,
Tissue engineering
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143392187&origin=inward
https://hdl.handle.net/11511/101499
Journal
Journal of the Korean Ceramic Society
DOI
https://doi.org/10.1007/s43207-022-00275-0
Collections
Department of Engineering Sciences, Article
Suggestions
OpenMETU
Core
Preparation and characterization of poly(epsilon-caprolactone) scaffolds modified with cell-loaded fibrin gel
Malikmammadov, Elbay; Endoğan Tanır, Tuğba; Kızıltay, Aysel; Hasırcı, Nesrin (2019-03-15)
Poly(epsilon-caprolactone) (PCL) is one of the most commonly used polymers in the production of tissue engineered scaffolds for hard tissue treatments. Incorporation of cells into these scaffolds significantly enhances the healing rate of the tissue. In this study, PCL scaffolds were prepared by wet spinning technique and modified by addition of fibrinogen in order to form a fibrin network between the PCL fibers. By this way, scaffolds would have micro and nanofibers in their structures. Drying of the wet s...
Preparation of Barium doped Baghdadite/PHBV fibrous scaffolds for bone tissue engineering
Sadreddini, Sanaossadat; Evis, Zafer; Keskin, Dilek; Department of Biomedical Engineering (2023-1-23)
Recently, bioceramic/polymer composites have dragged a lot of attention for treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop fibrous composite poly(hydroxybutyrate) co (hydroxyvalerate)- polycaprolactone, PHBV-PCL, scaffolds containing different amounts of baghdadite (BAG) and Ba-doped BAG that can provide bone regeneration in the bone defect area and to investigate the effect of these scaffolds on the structural, mechanical, and biological propertie...
Synthesis of selenium-incorporated alpha-tricalcium phosphate and evaluation of its cement-type reactivity
Baştuğ Azer, Bersu; Durucan, Caner; Department of Metallurgical and Materials Engineering (2019)
In the case of bone defects and damages synthetic bone grafts have been widely used for filling the damaged parts. Alpha-tricalcium phosphate (α-TCP) is an attractive calcium orthophosphate as replacement of hard tissues. It converts from powder form to hardened apatite, by cement-type reaction in aqueous solutions, which is therefore a promising hard bone tissue analog and clinically used in bone defect filling operations. In this concept adding therapeutic function to the hardened cement products is an ad...
Development of manganese-doped hydroxyapatite incorporated PCL electrospun 3D scaffolds coated with gelatin for bone tissue engineering
Samiei, Alaleh; Keskin, Dilek; Evis, Zafer; Department of Biomedical Engineering (2023-1-27)
Combination of polymers and bioceramics has increased their importance in bone tissue engineering (BTE) to treat various defects. Within this frame, in this thesis, it is aimed to develop a 3D gelatin-coated PCL scaffold combined with Mn-doped hydroxyapatite (HA) in order to investigate the effect of the doping element, i.e., the manganese (Mn) ion, on the structural and biological properties of the composite scaffold. Pure and Mn-doped HAs were synthesized using microwave irradiation, and the samples were ...
3D Porous Composite Scaffold of PCL-PEG-PCL/Sr2+ and Mg2+ Ions Co-Doped Borate Hydroxyapatite for Bone Tissue Engineering
Yedekçi, Buşra; Evis, Zafer; Tezcaner, Ayşen; Department of Engineering Sciences (2021-9-6)
Bioceramic/polymer composite systems have gained importance in treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop 3D porous composite PCL-PEG-PCL scaffolds containing different amounts of B, Sr and Mg multi-doped hydroxyapatite (HA) that can provide bone regeneration in the bone defect area and to investigate the effect of both the amount of inorganic phase and the porosity on the mechanical and the biological properties. B-Sr-Mg multi-doped HAs were s...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
H. Jodati, A. Tezcaner, Z. Evis, A. Z. Alshemary, and E. ÇELİK, “Synthesis of baghdadite using modified sol–gel route and investigation of its properties for bone treatment applications,”
Journal of the Korean Ceramic Society
, pp. 0–0, 2022, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143392187&origin=inward.