Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Preparation of Barium doped Baghdadite/PHBV fibrous scaffolds for bone tissue engineering
Download
Sanaossadat Sadreddini.pdf
Date
2023-1-23
Author
Sadreddini, Sanaossadat
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
256
views
78
downloads
Cite This
Recently, bioceramic/polymer composites have dragged a lot of attention for treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop fibrous composite poly(hydroxybutyrate) co (hydroxyvalerate)- polycaprolactone, PHBV-PCL, scaffolds containing different amounts of baghdadite (BAG) and Ba-doped BAG that can provide bone regeneration in the bone defect area and to investigate the effect of these scaffolds on the structural, mechanical, and biological properties. BAG and Ba-doped BAGs were synthesized using the sol-gel method and sintered at 1150oC. Microstructural and biological characterization results were evaluated and 4 different groups were selected for scaffold constructions. PHBV/PCL composite scaffolds containing different amounts of BAG and Ba-doped BAG (1, 3, and 5 wt%) were produced by the wet electrospinning method with a porosity of 72-78%. The presence of Ba-doped BAG in the PHBV scaffolds resulted in increasing bioactivity, cell viability, and ALP activity, and it was introduced as a suitable way to control the degradation rate of scaffolds. The presence of BAG in the scaffolds improved the compressive strength of the scaffolds. The compressive strength of the scaffolds was between 4.69-9.28 vi kPa and the 5% Ba0.3-BAG+PHBV/PCL scaffold was found to have the maximum compressive strength. In the relative cell viability (%) test, the highest viability was observed on the scaffolds with BAG. The viability changes were very small between groups and contradictory with Ba content for different BAG % groups. It was concluded that PHBV/PCL electrospun scaffold with 5% Ba-BAG has the potential to be used in BTE.
Subject Keywords
Ba doped baghdadite,
,
PHBV/PCL
,
Composite scaffolds
,
Bone tissue engineering
,
Electrospinning
URI
https://hdl.handle.net/11511/102044
Collections
Graduate School of Natural and Applied Sciences, Thesis
Suggestions
OpenMETU
Core
Development of manganese-doped hydroxyapatite incorporated PCL electrospun 3D scaffolds coated with gelatin for bone tissue engineering
Samiei, Alaleh; Keskin, Dilek; Evis, Zafer; Department of Biomedical Engineering (2023-1-27)
Combination of polymers and bioceramics has increased their importance in bone tissue engineering (BTE) to treat various defects. Within this frame, in this thesis, it is aimed to develop a 3D gelatin-coated PCL scaffold combined with Mn-doped hydroxyapatite (HA) in order to investigate the effect of the doping element, i.e., the manganese (Mn) ion, on the structural and biological properties of the composite scaffold. Pure and Mn-doped HAs were synthesized using microwave irradiation, and the samples were ...
3D Porous Composite Scaffold of PCL-PEG-PCL/Sr2+ and Mg2+ Ions Co-Doped Borate Hydroxyapatite for Bone Tissue Engineering
Yedekçi, Buşra; Evis, Zafer; Tezcaner, Ayşen; Department of Engineering Sciences (2021-9-6)
Bioceramic/polymer composite systems have gained importance in treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop 3D porous composite PCL-PEG-PCL scaffolds containing different amounts of B, Sr and Mg multi-doped hydroxyapatite (HA) that can provide bone regeneration in the bone defect area and to investigate the effect of both the amount of inorganic phase and the porosity on the mechanical and the biological properties. B-Sr-Mg multi-doped HAs were s...
3D porous PCL-PEG-PCL / strontium, magnesium and boron multi-doped hydroxyapatite composite scaffolds for bone tissue engineering
Yedekçi, Buşra; Tezcaner, Ayşen; Evis, Zafer (2022-01-01)
Bioceramic/polymer composite systems have gained importance in treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop 3D porous composite PCL-PEG-PCL scaffolds containing different amounts of B, Sr and Mg multi-doped HA that can provide bone regeneration in the bone defect area and to investigate the effect of both the amount of inorganic phase and the porosity on the mechanical and the biological properties. B-Sr-Mg multi-doped HA and PCL-PEG-PCL copolyme...
Synthesis of baghdadite using modified sol–gel route and investigation of its properties for bone treatment applications
Jodati, Hossein; Tezcaner, Ayşen; Evis, Zafer; Alshemary, Ammar Z; ÇELİK, ERDAL (2022-01-01)
The requirement for biomaterials with superior properties, used in bone treatment applications, is inevitable due to escalated bone tissue defects. Baghdadite (BAG) is a calcium silicate that benefits from the presence of zirconium (Zr) in its structure and has attracted huge attention in recent years. In this study, a modified sol–gel route was proposed to synthesize BAG by dissolving Zr precursor separately and using optimum amounts of solvent and chelating agent. Due to thermal gravimetric analysis and d...
3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering
Jodati, Hossein; Evis, Zafer; Tezcaner, Ayşen; Alshemary, Ammar Z.; Motameni, Ali (2023-04-01)
Making composite scaffolds is one of the well-known methods to improve the properties of scaffolds used in bone tissue engineering. In this study, novel ceramic-based 3D porous composite scaffolds were successfully prepared using boron-doped hydroxyapatite, as the primary component, and baghdadite, as the secondary component. The effects of making composites on the properties of boron-doped hydroxyapatite-based scaffolds were investigated in terms of physicochemical, mechanical, and biological properties. T...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
S. Sadreddini, “Preparation of Barium doped Baghdadite/PHBV fibrous scaffolds for bone tissue engineering,” M.S. - Master of Science, Middle East Technical University, 2023.