Fabrication and in vitro characterization of antibacterial magneto-luminescent core-shell bioactive glass nanoparticles

Date

2023-01-01

Author

Unal, Fatma
Tasar, Cansu
Ercan, Batur

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When nanomaterials with antibacterial properties were sent to the infected area, it was predicted that infection and related complications could be prevented. The nanoparticles can be designed to possess magnetic and luminescence (magneto-luminescent) properties to be effectively targeted and localized at the infection foci without dispersing into the body. Simultaneously, the magneto-luminescent characteristic of particles allows visualization and confirmation of localized particles at the desired area. In this regard, there are no studies on the use of antibacterial magneto-luminescent bioactive glass for orthopedic applications and the treatment of orthopedic device-related infections. In this study, antibacterial magneto-luminescent 58S bioactive glasses were synthesized by the modified Stöber using coupled with a layer-by-layer assembly approach to possess core/shell particle morphology. SPION/Bioactive glass nanoparticles had an average size of 50 nm and displayed superparamagnetic behavior. While the saturation magnetization value (σs) of the undoped 58S sample was 25.32 emu/g, that of the co-doped sample (2% Eu, 2% Zn) was 21.74 emu/g; this showed that the doping slightly reduced the magnetization value. Europium (Eu) doping of SPION/Bioactive glass nanoparticles induced characteristic red emission originating from Eu emissions belonging to 5D0–7FJ (J = 1–4) transitions and the strongest peak was at 612 nm (electric-dipole transition, 5D0–7F2). Color chromaticity coordinates confirmed emission in the red region. XPS spectrum revealed the existence of Eu and Zn dopant elements in 58S bioactive glass. After soaking characteristic peaks at 31.74° and 45.43° belonging to the hexagonal hydroxyapatite phase were detected in the XRD data, confirming the SEM images. 2% Eu doped SPION/Bioactive glass nanoparticles had the highest osteoblast viability up to 7 days in vitro, while doping the samples with 2% zinc did not yield bone cell viability as high as the Eu doped ones. Importantly, Eu doped SPION/Bioactive glass nanoparticles inhibited gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli) growth up to 48 h in vitro. The results showed that Eu doping of SPION/Bioactive glass nanoparticles increased osteoblast viability and inhibited bacterial growth, while possessing superparamagnetic properties and exhibiting red luminescence.

Subject Keywords

Antibacterial, Bioactive glass, Core/shell nanoparticles, Europium, Luminescence, Magnetic

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150266610&origin=inward
https://hdl.handle.net/11511/102634

Journal

Ceramics International

DOI

https://doi.org/10.1016/j.ceramint.2023.03.135

Collections

Department of Metallurgical and Materials Engineering, Article

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Citation Formats

F. Unal, C. Tasar, and B. Ercan, “Fabrication and in vitro characterization of antibacterial magneto-luminescent core-shell bioactive glass nanoparticles,” Ceramics International, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150266610&origin=inward.