Fabrication and in vitro characterization of antibacterial magneto-luminescent core-shell bioactive glass nanoparticles

Date

2023-01-01

Author

Unal, Fatma
Tasar, Cansu
Ercan, Batur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

96
views

0
downloads

When nanomaterials with antibacterial properties were sent to the infected area, it was predicted that infection and related complications could be prevented. The nanoparticles can be designed to possess magnetic and luminescence (magneto-luminescent) properties to be effectively targeted and localized at the infection foci without dispersing into the body. Simultaneously, the magneto-luminescent characteristic of particles allows visualization and confirmation of localized particles at the desired area. In this regard, there are no studies on the use of antibacterial magneto-luminescent bioactive glass for orthopedic applications and the treatment of orthopedic device-related infections. In this study, antibacterial magneto-luminescent 58S bioactive glasses were synthesized by the modified Stöber using coupled with a layer-by-layer assembly approach to possess core/shell particle morphology. SPION/Bioactive glass nanoparticles had an average size of 50 nm and displayed superparamagnetic behavior. While the saturation magnetization value (σs) of the undoped 58S sample was 25.32 emu/g, that of the co-doped sample (2% Eu, 2% Zn) was 21.74 emu/g; this showed that the doping slightly reduced the magnetization value. Europium (Eu) doping of SPION/Bioactive glass nanoparticles induced characteristic red emission originating from Eu emissions belonging to 5D0–7FJ (J = 1–4) transitions and the strongest peak was at 612 nm (electric-dipole transition, 5D0–7F2). Color chromaticity coordinates confirmed emission in the red region. XPS spectrum revealed the existence of Eu and Zn dopant elements in 58S bioactive glass. After soaking characteristic peaks at 31.74° and 45.43° belonging to the hexagonal hydroxyapatite phase were detected in the XRD data, confirming the SEM images. 2% Eu doped SPION/Bioactive glass nanoparticles had the highest osteoblast viability up to 7 days in vitro, while doping the samples with 2% zinc did not yield bone cell viability as high as the Eu doped ones. Importantly, Eu doped SPION/Bioactive glass nanoparticles inhibited gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli) growth up to 48 h in vitro. The results showed that Eu doping of SPION/Bioactive glass nanoparticles increased osteoblast viability and inhibited bacterial growth, while possessing superparamagnetic properties and exhibiting red luminescence.

Subject Keywords

Antibacterial, Bioactive glass, Core/shell nanoparticles, Europium, Luminescence, Magnetic

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150266610&origin=inward
https://hdl.handle.net/11511/102634

Journal

Ceramics International

DOI

https://doi.org/10.1016/j.ceramint.2023.03.135

Collections

Department of Metallurgical and Materials Engineering, Article

Suggestions

OpenMETU
Core

SYNTHESIS OF NOVEL MATERIALS FOR HIGH PERFORMANCE POLYMERIC MEMBRANE APPLICATIONS TUL MUNNA, SADIA; Akdağ, Akın; Çulfaz Emecen, Pınar Zeynep; Department of Polymer Science and Technology (2021-9-10) The polymeric membranes for antimicrobial applications are in high demand nowadays, since the bacteria had developed the resistance against the antibiotics. The membrane technology could become an efficient tool to cope with the antibiotic resistant bacteria which are becoming an unevitable problem on the health and pocket of a common man. To address this issue, the current research is carried out to synthesize polymer with antibacterial properties. Norbornene and oxonorborne monomers with special modificat...
Development and analysis of controlled release polymeric rods containing vancomycin Tağıt, Oya; Hasırcı, Vasıf Nejat; Department of Biotechnology (2005) Antibiotic use is a vital method for the treatment of most diseases involving bacterial infections. Unfortunately, in certain cases these agents are not effective in treatments against diseases for either some limitation in antibiotic usage because of the side effects or some distribution problems caused by physiological or pathological barriers in the body. Such problems are thought to be minimized by development of controlled release systems which involve implantation of antibiotic loaded polymeric system...
EVALUATION OF ANTIBACTERIAL AND CARBONIC ANHYDRASE INHIBITORY POTENTIAL OF METHANOLIC EXTRACT OF &ITNARDOSTACHYS JATAMANSI&IT (D. DON) DC RHIZOMES Rehman, Tayyeba; Ahmad, Saeed; Abbasi, Waheed Mumtaz; Ahmad, Ashfaq; Bilal, Muhammad; Zaman, Muhammad Mohsin; Ghauri, Aymen Owais; Arshad, Adeel; Akhtar, Khalid (2017-09-01) Many antimicrobial drugs are going to become resistant to different pathogens, so the discovery of new antimicrobial products is an important public health concern. Nardostachys jatamansi (D. Don) DC (Valerianaceae) is an important traditional herbal medicine used as tranquillizer. CNS sedative. antiepilepsy, cardiotonic. diuretic, heptatonic, analgesic and in boils, itch and eye diseases. Carbonic anhydrase inhibitors are the potential source of treatment in case of glaucoma, hypertension and epilepsy and ...
Characterization and genomic analysis of a novel bacteriophage against methicillin-resistant staphylococcus aureus Çotak, Medine; Akkaya, Mahinur S.; Karahan, Zeynep Ceren; Department of Biotechnology (2019) Methicillin resistant Staphylococcus aureus (MRSA) is one of the most frequent hospital and community acquired infectious agents causing severe diseases. Bacteriophages may offer a solution to treat the bacterial infections that are not responding to classical antibiotics. In this context, a new lytic phage, named as vB_SauM-MikSA913, was isolated from sewage treatment center in Samsun (Turkey). MRSA clinical strains obtained from a local hospital were used as propagating hosts while searching for the lytic...
Thermostabilization of panomycocin, a novel exo-beta-1,3-glucanase isolated from pichia anomala NCYC 434, by using excipients and computational methods Muhammed, Muhammed Tilahun; İzgü, Kadri Fatih; Son, Çağdaş Devrim; Department of Biomedical Engineering (2015) As the risks for fungal infections increased, the prevalence of invasive fungal infections increased. Therefore, the demand for antifungal agents has risen. Moreover, the currently used antifungal agents have serious side effects and resistance development resulting from their mechanisms of action. Thus, novel antifungal agents with mechanisms that will not affect the host mammalian cells are in need. Yeast killer proteins which are naturally occuring toxins are good candidates for such types of agents. Pan...

Citation Formats

F. Unal, C. Tasar, and B. Ercan, “Fabrication and in vitro characterization of antibacterial magneto-luminescent core-shell bioactive glass nanoparticles,” Ceramics International, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150266610&origin=inward.