3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering

Date

2023-04-01

Author

Jodati, Hossein
Evis, Zafer
Tezcaner, Ayşen
Alshemary, Ammar Z.
Motameni, Ali

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

191
views

0
downloads

Making composite scaffolds is one of the well-known methods to improve the properties of scaffolds used in bone tissue engineering. In this study, novel ceramic-based 3D porous composite scaffolds were successfully prepared using boron-doped hydroxyapatite, as the primary component, and baghdadite, as the secondary component. The effects of making composites on the properties of boron-doped hydroxyapatite-based scaffolds were investigated in terms of physicochemical, mechanical, and biological properties. The incorporation of baghdadite contributed to making more porous scaffolds (over 40%) with larger surface area and micropore volumes. The produced composite scaffolds almost solved the low degradation problem of boron-doped hydroxyapatite through the exhibition of higher biodegradation rates, which matched the degradation rate appropriate for the gradual transfer of loads from implants to newly formed bone tissues. Besides higher bioactivity, enhanced cell proliferation, as well as higher osteogenic differentiation (in scaffolds with baghdadite weight greater than 10%), were observed in composite scaffolds due to both physical and chemical modifications that occurred in composite scaffolds. Although our composite scaffolds were slightly weaker than boron-doped hydroxyapatite, their compressive strengths were higher than almost all composite scaffolds made by baghdadite incorporation in the literature. In fact, boron-doped hydroxyapatite provided a base for baghdadite to show mechanical strength suitable for cancellous bone defect treatments. Eventually, our novel composite scaffolds converged the advantages of both components to satisfy the various requirements needed for bone tissue engineering applications and take us one step forward on the road to fabricating an ideal scaffold.

Subject Keywords

Baghdadite, Bone, Boron-doped hydroxyapatite, Composite, Scaffold, Tissue engineering

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148039036&origin=inward
https://hdl.handle.net/11511/102649

Journal

Journal of the Mechanical Behavior of Biomedical Materials

DOI

https://doi.org/10.1016/j.jmbbm.2023.105722

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

3D porous PCL-PEG-PCL / strontium, magnesium and boron multi-doped hydroxyapatite composite scaffolds for bone tissue engineering Yedekçi, Buşra; Tezcaner, Ayşen; Evis, Zafer (2022-01-01) Bioceramic/polymer composite systems have gained importance in treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop 3D porous composite PCL-PEG-PCL scaffolds containing different amounts of B, Sr and Mg multi-doped HA that can provide bone regeneration in the bone defect area and to investigate the effect of both the amount of inorganic phase and the porosity on the mechanical and the biological properties. B-Sr-Mg multi-doped HA and PCL-PEG-PCL copolyme...
3-dimensional boron-doped hydroxyapatite/baghdadite porous scaffolds for bone tissue engineering Jodati, Hossein; Evis, Zafer; Şahin, Volkan; Department of Biomedical Engineering (2023-1-16) A wide range of biomaterials is used to fabricate scaffolds for hard tissue engineering. However, perfect scaffolds with the required characteristics to answer all clinical needs have not been produced yet. In this thesis, a novel ceramic-based chemical combination of boron-doped hydroxyapatite (BHA) and baghdadite (BAG) was employed to fabricate composite 3-dimensional (3D) porous scaffolds to promote scaffolds’ properties. The ultimate goal was achieved through the following steps: 1) BHA powders with dif...
Development of manganese-doped hydroxyapatite incorporated PCL electrospun 3D scaffolds coated with gelatin for bone tissue engineering Samiei, Alaleh; Keskin, Dilek; Evis, Zafer; Department of Biomedical Engineering (2023-1-27) Combination of polymers and bioceramics has increased their importance in bone tissue engineering (BTE) to treat various defects. Within this frame, in this thesis, it is aimed to develop a 3D gelatin-coated PCL scaffold combined with Mn-doped hydroxyapatite (HA) in order to investigate the effect of the doping element, i.e., the manganese (Mn) ion, on the structural and biological properties of the composite scaffold. Pure and Mn-doped HAs were synthesized using microwave irradiation, and the samples were ...
Development of porous chitosan-gelatin/hydroxyapatite composite scaffolds for hard tissue-engineering applications Isikli, C.; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2012-02-01) Composite scaffolds prepared from natural polymers and hydroxyapatite (HA) are expected to have enhanced osteoconductive properties and as a result gained much attention in recent years for use in bone tissue-engineering applications. Although there are various natural polymers available for this purpose, chitosan (C) and gelatin (G) are commonly studied because of their inherent properties. The aim of this study was to prepare three-dimensional (3D) scaffolds using these two natural polymers and to add eit...
3D Porous Composite Scaffold of PCL-PEG-PCL/Sr2+ and Mg2+ Ions Co-Doped Borate Hydroxyapatite for Bone Tissue Engineering Yedekçi, Buşra; Evis, Zafer; Tezcaner, Ayşen; Department of Engineering Sciences (2021-9-6) Bioceramic/polymer composite systems have gained importance in treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop 3D porous composite PCL-PEG-PCL scaffolds containing different amounts of B, Sr and Mg multi-doped hydroxyapatite (HA) that can provide bone regeneration in the bone defect area and to investigate the effect of both the amount of inorganic phase and the porosity on the mechanical and the biological properties. B-Sr-Mg multi-doped HAs were s...

Citation Formats

H. Jodati, Z. Evis, A. Tezcaner, A. Z. Alshemary, and A. Motameni, “3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering,” Journal of the Mechanical Behavior of Biomedical Materials, vol. 140, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148039036&origin=inward.