3-dimensional boron-doped hydroxyapatite/baghdadite porous scaffolds for bone tissue engineering

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Hossein Jodati PhD Thesis.pdf

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2023-1-16

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Jodati, Hossein

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A wide range of biomaterials is used to fabricate scaffolds for hard tissue engineering. However, perfect scaffolds with the required characteristics to answer all clinical needs have not been produced yet. In this thesis, a novel ceramic-based chemical combination of boron-doped hydroxyapatite (BHA) and baghdadite (BAG) was employed to fabricate composite 3-dimensional (3D) porous scaffolds to promote scaffolds’ properties. The ultimate goal was achieved through the following steps: 1) BHA powders with different molar ratios of boron dopant were synthesized, their physicochemical, mechanical, as well as in vitro biological characteristics were evaluated, and the optimum group was selected. 2) Through the modified sol-gel technique, which was proposed and optimized for the first time, synthesis and characterization of BAG nanoparticles were accomplished by overcoming the premature gelation problem. 3) The novel ceramic-based 3D porous composite scaffolds were successfully prepared using BHA and BAG as the primary and secondary components. The incorporation of BAG contributed to making more porous scaffolds (over 40 %) with larger surface area and micropore volumes. The composite scaffolds almost solved the low degradation problem of BHA, where their higher degradations matched the degradation rate appropriate for the gradual transfer of loads from implants to newly formed bone. Besides higher bioactivity, enhanced cell proliferation, and higher osteogenic differentiation were observed in composite scaffolds. Eventually, BHA-BAG composite scaffolds converged the advantages of both components to satisfy the various requirements needed for bone tissue engineering applications and took us one step forward on the road to producing an ideal scaffold.

Subject Keywords

Boron-doped hydroxyapatite, Baghdadite, Composite, Scaffold

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https://hdl.handle.net/11511/102013

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Graduate School of Natural and Applied Sciences, Thesis

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3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering Jodati, Hossein; Evis, Zafer; Tezcaner, Ayşen; Alshemary, Ammar Z.; Motameni, Ali (2023-04-01) Making composite scaffolds is one of the well-known methods to improve the properties of scaffolds used in bone tissue engineering. In this study, novel ceramic-based 3D porous composite scaffolds were successfully prepared using boron-doped hydroxyapatite, as the primary component, and baghdadite, as the secondary component. The effects of making composites on the properties of boron-doped hydroxyapatite-based scaffolds were investigated in terms of physicochemical, mechanical, and biological properties. T...
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Citation Formats

H. Jodati, “3-dimensional boron-doped hydroxyapatite/baghdadite porous scaffolds for bone tissue engineering,” Ph.D. - Doctoral Program, Middle East Technical University, 2023.