3-dimensional boron-doped hydroxyapatite/baghdadite porous scaffolds for bone tissue engineering

Download

Hossein Jodati PhD Thesis.pdf

Date

2023-1-16

Author

Jodati, Hossein

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

326
views

149
downloads

A wide range of biomaterials is used to fabricate scaffolds for hard tissue engineering. However, perfect scaffolds with the required characteristics to answer all clinical needs have not been produced yet. In this thesis, a novel ceramic-based chemical combination of boron-doped hydroxyapatite (BHA) and baghdadite (BAG) was employed to fabricate composite 3-dimensional (3D) porous scaffolds to promote scaffolds’ properties. The ultimate goal was achieved through the following steps: 1) BHA powders with different molar ratios of boron dopant were synthesized, their physicochemical, mechanical, as well as in vitro biological characteristics were evaluated, and the optimum group was selected. 2) Through the modified sol-gel technique, which was proposed and optimized for the first time, synthesis and characterization of BAG nanoparticles were accomplished by overcoming the premature gelation problem. 3) The novel ceramic-based 3D porous composite scaffolds were successfully prepared using BHA and BAG as the primary and secondary components. The incorporation of BAG contributed to making more porous scaffolds (over 40 %) with larger surface area and micropore volumes. The composite scaffolds almost solved the low degradation problem of BHA, where their higher degradations matched the degradation rate appropriate for the gradual transfer of loads from implants to newly formed bone. Besides higher bioactivity, enhanced cell proliferation, and higher osteogenic differentiation were observed in composite scaffolds. Eventually, BHA-BAG composite scaffolds converged the advantages of both components to satisfy the various requirements needed for bone tissue engineering applications and took us one step forward on the road to producing an ideal scaffold.

Subject Keywords

Boron-doped hydroxyapatite, Baghdadite, Composite, Scaffold

URI

https://hdl.handle.net/11511/102013

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering Jodati, Hossein; Evis, Zafer; Tezcaner, Ayşen; Alshemary, Ammar Z.; Motameni, Ali (2023-04-01) Making composite scaffolds is one of the well-known methods to improve the properties of scaffolds used in bone tissue engineering. In this study, novel ceramic-based 3D porous composite scaffolds were successfully prepared using boron-doped hydroxyapatite, as the primary component, and baghdadite, as the secondary component. The effects of making composites on the properties of boron-doped hydroxyapatite-based scaffolds were investigated in terms of physicochemical, mechanical, and biological properties. T...
Development of manganese-doped hydroxyapatite incorporated PCL electrospun 3D scaffolds coated with gelatin for bone tissue engineering Samiei, Alaleh; Keskin, Dilek; Evis, Zafer; Department of Biomedical Engineering (2023-1-27) Combination of polymers and bioceramics has increased their importance in bone tissue engineering (BTE) to treat various defects. Within this frame, in this thesis, it is aimed to develop a 3D gelatin-coated PCL scaffold combined with Mn-doped hydroxyapatite (HA) in order to investigate the effect of the doping element, i.e., the manganese (Mn) ion, on the structural and biological properties of the composite scaffold. Pure and Mn-doped HAs were synthesized using microwave irradiation, and the samples were ...
Preparation of Barium doped Baghdadite/PHBV fibrous scaffolds for bone tissue engineering Sadreddini, Sanaossadat; Evis, Zafer; Keskin, Dilek; Department of Biomedical Engineering (2023-1-23) Recently, bioceramic/polymer composites have dragged a lot of attention for treating hard tissue damages using bone tissue engineering (BTE). In this context, it was aimed to develop fibrous composite poly(hydroxybutyrate) co (hydroxyvalerate)- polycaprolactone, PHBV-PCL, scaffolds containing different amounts of baghdadite (BAG) and Ba-doped BAG that can provide bone regeneration in the bone defect area and to investigate the effect of these scaffolds on the structural, mechanical, and biological propertie...
Electrospinning of chitosan/poly(lactic acid-co-glycolic acid)/hydroxyapatite composite nanofibrous mats for tissue engineering applications Endoğan Tanır, Tuğba; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2014-11-01) Electrospinning, which is a fiber fabrication technique using electrical forces to produce fibers with diameters ranging from nanometers to several micrometers, can be used to prepare materials mimicking the extracellular matrix proteins for potential use as tissue engineering scaffolds. In this study, nanofibrous mats of chitosan (CH) and poly(lactic acid-co-glycolic acid) (PLGA) having fiber diameters between 167 to 525 nm, and containing hydroxyapatite (HAp), were prepared by electrospinning technique. M...
Co-doped hydroxyapatites as potential materials for biomedical applications YILMAZ, BENGİ; ALSHEMARY, AMMAR ZEIDAN GHAILAN; Evis, Zafer (2019-01-01) Hydroxyapatite (HA) is a synthetic biomaterial resembling the composition of mammalian hard tissue and thus, it is widely employed as a bone graft material, hard tissue engineering scaffold and coating layer for metallic substrates. Biological apatite is non-stoichiometric in nature. It is composed of small crystals and characterized by poor crystallinity and relatively high solubility with respect to stoichiometric HA. Chemical compositions of these crystals consist of Ca, P and trace amounts of various io...

Citation Formats

H. Jodati, “3-dimensional boron-doped hydroxyapatite/baghdadite porous scaffolds for bone tissue engineering,” Ph.D. - Doctoral Program, Middle East Technical University, 2023.