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UV responsive drug delivery from suprofen incorporated liposomes
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Date
2011
Author
Demirbağ, Birsen
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Drug delivery systems are designed to achieve low, local doses at the target site. Delivery systems can provide the drug in a continuous manner or in response to environmental stimuli such as temperature, pH or UV. This study aimed to develop photosensitive liposomes that achieve UV-responsive release of their content. The main mechanism was to incorporate a light sensitive molecule into the liposomal bilayer then achieve destabilization of the membrane by exposure to UV. This would result in an on demand release of the bioactive content. Suprofen, a nonstereoidal anti-inflammatory drug, also a light sensitive molecule, was selected to achieve the destabilization in this study. Lipid vesicles were prepared with different ratios of phosphatidyl choline, cholesterol and Suprofen (PC:CHOL:SPF) and characterized in terms of encapsulation efficiency, release rate and responsiveness to UV. Preliminary studies were carried out with calcein (CAL), a fluorescent dye, due to the ease of detection and the in vitro studies were carried out with the cancer drug Cisplatin.
Subject Keywords
Drug delivery systems.
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http://etd.lib.metu.edu.tr/upload/12613711/index.pdf
https://hdl.handle.net/11511/21097
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Graduate School of Natural and Applied Sciences, Thesis
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B. Demirbağ, “UV responsive drug delivery from suprofen incorporated liposomes,” M.S. - Master of Science, Middle East Technical University, 2011.
