Surface functionalization of sba-15 particles for celecoxib delivery

Download
index.pdf
2013
Gezer, Gamze
Show full item record
283
views
141
downloads
Mesoporous silica particles have been used to enhance the loading capacity of drugs into these particles, increase bioavailability and control drug release. In this study SBA-15 particles were synthesized and functionalized to improve the loading capacity and release rate of drug. Then, drug loading and release process were investigated. Celecoxib was chosen as a model drug which is very hydrophobic. SBA-15 particles were used due to their highly ordered, well-defined mesoporous structure. These particles were modified by post-grafting method. In order to synthesize SBA-15 particles, hydrothermal synthesis method was used, Pluronic 123 triblock copolymer was used as starting material and tetraethyl orthosilicate was added as a silica source. SBA-15 samples were functionalized by post-grafting method with (3-Aminopropyl) triethoxysilane (APTES). Moreover, Boron doping of SBA-15 samples was prepared and so borosilicate samples were obtained. After functionalization process, drug loading of samples were performed with different concentration of drug in silica and to control drug release rate, release experiments results were compared. For the characterization process of pure and drug loaded samples, X-ray Diffraction (XRD), Small-Angle X-ray Spectrometry (SAXS), N2 adsorption-desorption, Fourier Transform Infra-red (FTIR), Elemental Analysis, Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Ultra-Violet Spectrometry (UV-VIS), Zeta Potential and High-Performance Liquid Chromatography (HPLC) methods were applied. According to characterization process, amine functionalized SBA-15 samples and borosilicate samples showed the best results in loading and release experiments. For loading process amine functionalized SBA-15 particles had 61.72 % efficiency and borosilicate samples had 76.33 % efficiency. Besides, Borosilicate and amine functionalized SBA-15 samples had highest release rate of Celecoxib which were 37.57 % and 41.61 % respectively. Functionalization process was successful to improve drug loading capacity and release rate.
Celecoxib., Drug delivery systems., Silica.
http://etd.lib.metu.edu.tr/upload/12615961/index.pdf
https://hdl.handle.net/11511/22645
Graduate School of Natural and Applied Sciences, Thesis

Suggestions

Inclusion of celecoxib in the SBA-15 mesoporous silica: drug loading and release property
Eren, Zeynep Seda; Yılmaz, Ayşen; Department of Chemistry (2016)
Mesoporous silica particles have been used to enhance the loading capacity of drugs into the support, increase the solubility of drug and control drug release. In this study, poorly water-soluble, nonsteroidal anti-inflammatory drug with relatively low bioavailability Celecoxib, was used as a model drug in order to determine the drug loading and release properties of silica particles. In order to synthesize SBA15 particles, hydrothermal synthesis method was used, SBA-15 samples were functionalized by post-g...
Inclusion of celecoxib in the MCM – 41 mesoporous silica: drug loading and release property
Günaydin, Şahika; Yılmaz, Ayşen; Department of Chemistry (2014)
Mesoporous silica particles have been used to enhance the biocompability of the drugs and provide control drug release. Celecoxib was chosen as a model drug which is poorly water soluble non-steroidal anti-inflammatory drug. In this study, in order to determine the morphology effect on the drug loading capacity of the silica particles and release properties of the drug, MCM-41 particles were synthesized with different particle size, pore volume and surface properties. MCM-41-1 and MCM-41-2 labeled particles...
Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release
Eren, Zeynep Seda; Tuncer, Sinem; Gezer, Gamze; Yildirim, Leyla Tatar; Banerjee, Sreeparna; Yılmaz, Ayşen (2016-11-15)
In this study, celecoxib (CLX), a highly hydrophobic nonsteroidal anti-inflammatory drug with relatively low bioavailability, was used as a model drug to determine loading in different solvents and release properties from silica particles. Hydrothermal synthesis method was used to synthesize SBA-15 particles, which were functionalized by post-synthesis grafting method with (3-Aminopropyl) triethoxysilane (APTES). Additionally, boron doped SBA-15 samples were prepared to generate borosilicate samples. After ...
Surface functionalization of SBA-15 particles for amoxicillin delivery
Sevimli, Filiz; Yılmaz, Ayşen (2012-08-01)
The hydrothermally synthesized SBA-15 particles were surface functionalized by post-grafting synthesis method with (3-aminopropyl) triethoxy silane, mercaptopropyl trimethoxy silane and triethoxy methyl silane in order to be used as carrier materials for drug delivery. Amoxicillin was used as a model drug. The adsorption and release properties of calcined and organic-functionalized mesoporous silicas containing terminal primary amine, organothiol and methyl groups toward amoxicillin have been investigated. ...
Surface and modification of LP-SBA-15 with polyethyleneimine for celecoxib delivery
Farid, Ali; Yılmaz, Ayşen; Banerjee, Sreeparna; Department of Micro and Nanotechnology (2017)
In this study LP-SBA-15 (LP stands for large pores) and LP-SBA-15-PEI (PEI stands for polyethyleneimine), ordered mesoporous silica support material utilized with different pore structure characteristics to investigate on their drug delivery system abilities like release and loading properties, regarding to their structural variability and implication of surface modification. Hydrothermal synthesis method was used for synthesis of LP-SBA-15 and surface functionalization was done by polymerization of hyperbr...
Citation Formats
G. Gezer, “Surface functionalization of sba-15 particles for celecoxib delivery,” M.S. - Master of Science, Middle East Technical University, 2013.
METU IIS - Integrated Information Service open@metu.edu.tr