Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release

Date

2016-11-15

Author

Eren, Zeynep Seda
Tuncer, Sinem
Gezer, Gamze
Yildirim, Leyla Tatar
Banerjee, Sreeparna
Yılmaz, Ayşen

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

219
views

0
downloads

In this study, celecoxib (CLX), a highly hydrophobic nonsteroidal anti-inflammatory drug with relatively low bioavailability, was used as a model drug to determine loading in different solvents and release properties from silica particles. Hydrothermal synthesis method was used to synthesize SBA-15 particles, which were functionalized by post-synthesis grafting method with (3-Aminopropyl) triethoxysilane (APTES). Additionally, boron doped SBA-15 samples were prepared to generate borosilicate samples. After functionalization, drug loading was carried out in three different solvents: ethanol, methanol and hexane and their effect on drug loading and release properties were examined. Particle morphology and solvent effect on drug loading capacity of silica particles, as well as the effect of pH on drug release were analyzed. For this purpose, SBA-15 particles were characterized by using X-ray Diffraction (XRD), Small Angle X-ray Spectrometry (SAXS), N-2 adsorption-desorption, Fourier Transform Infra-red Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Ultra-Violet Spectrometry (UV-VIS) and Thermogravimetric Analysis (TGA).

Subject Keywords

SBA-15 Particles, Surface Functionalization, Borosilicate, Drug Delivery Systems, Celecoxib

URI

https://hdl.handle.net/11511/36396

Journal

MICROPOROUS AND MESOPOROUS MATERIALS

DOI

https://doi.org/10.1016/j.micromeso.2016.08.014

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Inclusion of celecoxib in the SBA-15 mesoporous silica: drug loading and release property Eren, Zeynep Seda; Yılmaz, Ayşen; Department of Chemistry (2016) Mesoporous silica particles have been used to enhance the loading capacity of drugs into the support, increase the solubility of drug and control drug release. In this study, poorly water-soluble, nonsteroidal anti-inflammatory drug with relatively low bioavailability Celecoxib, was used as a model drug in order to determine the drug loading and release properties of silica particles. In order to synthesize SBA15 particles, hydrothermal synthesis method was used, SBA-15 samples were functionalized by post-g...
Surface functionalization of sba-15 particles for celecoxib delivery Gezer, Gamze; Yılmaz, Ayşen; Department of Chemistry (2013) Mesoporous silica particles have been used to enhance the loading capacity of drugs into these particles, increase bioavailability and control drug release. In this study SBA-15 particles were synthesized and functionalized to improve the loading capacity and release rate of drug. Then, drug loading and release process were investigated. Celecoxib was chosen as a model drug which is very hydrophobic. SBA-15 particles were used due to their highly ordered, well-defined mesoporous structure. These particles w...
Inclusion of celecoxib in the MCM – 41 mesoporous silica: drug loading and release property Günaydin, Şahika; Yılmaz, Ayşen; Department of Chemistry (2014) Mesoporous silica particles have been used to enhance the biocompability of the drugs and provide control drug release. Celecoxib was chosen as a model drug which is poorly water soluble non-steroidal anti-inflammatory drug. In this study, in order to determine the morphology effect on the drug loading capacity of the silica particles and release properties of the drug, MCM-41 particles were synthesized with different particle size, pore volume and surface properties. MCM-41-1 and MCM-41-2 labeled particles...
Optimization of microwave-assisted extraction of phenolic compounds from tomato: Characterization by FTIR and HPLC and comparison with conventional solvent extraction Baltacıoğlu, Hande; Baltacıoğlu, Cem; Okur, İlhami; Tanrıvermiş, Arif; Yalıç, Muharrem (Elsevier BV, 2021-03-01) © 2021 Elsevier B.V.In the extraction of phenolic compounds from tomato, Microwave-Assisted Extraction (MAE) was used as a novel technology in this study and compared to conventional solvent extraction (CSE). The optimal extraction conditions for tomato were determined using the multi-level factorial design. For this purpose, different powers (360, 600 and 900 W) and times (30, 60 and 90 s) were used for MAE and also different temperatures (40, 50 and 60 °C) and times (10, 20 and 30 min) were used for CSE. ...
Polymer foaming with supercritical carbon dioxide Novendra, Novendra; Dilek Hacıhabiboğlu, Çerağ; Hasırcı, Nesrin; Department of Chemical Engineering (2015) High molecular weight semi crystalline poly(L-lactic acid) (PLLA) was processed with environmentally benign and non-toxic supercritical carbon dioxide with and without the addition of two different additives to form porous polymeric thin films for biomedical applications such as drug delivery. One of the additives was a CO2-philic additive, trifluoropropyl polyhedral oligomeric silsesquioxane (TFPOSS), and the other was a non CO2-philic additive, octamethyl polyhedral oligomeric silsesquioxane (OMPOSS). Eve...

Citation Formats

Z. S. Eren, S. Tuncer, G. Gezer, L. T. Yildirim, S. Banerjee, and A. Yılmaz, “Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release,” MICROPOROUS AND MESOPOROUS MATERIALS, pp. 211–223, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36396.