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Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release
Date
2016-11-15
Author
Eren, Zeynep Seda
Tuncer, Sinem
Gezer, Gamze
Yildirim, Leyla Tatar
Banerjee, Sreeparna
Yılmaz, Ayşen
Metadata
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In this study, celecoxib (CLX), a highly hydrophobic nonsteroidal anti-inflammatory drug with relatively low bioavailability, was used as a model drug to determine loading in different solvents and release properties from silica particles. Hydrothermal synthesis method was used to synthesize SBA-15 particles, which were functionalized by post-synthesis grafting method with (3-Aminopropyl) triethoxysilane (APTES). Additionally, boron doped SBA-15 samples were prepared to generate borosilicate samples. After functionalization, drug loading was carried out in three different solvents: ethanol, methanol and hexane and their effect on drug loading and release properties were examined. Particle morphology and solvent effect on drug loading capacity of silica particles, as well as the effect of pH on drug release were analyzed. For this purpose, SBA-15 particles were characterized by using X-ray Diffraction (XRD), Small Angle X-ray Spectrometry (SAXS), N-2 adsorption-desorption, Fourier Transform Infra-red Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Ultra-Violet Spectrometry (UV-VIS) and Thermogravimetric Analysis (TGA).
Subject Keywords
SBA-15 Particles
,
Surface Functionalization
,
Borosilicate
,
Drug Delivery Systems
,
Celecoxib
URI
https://hdl.handle.net/11511/36396
Journal
MICROPOROUS AND MESOPOROUS MATERIALS
DOI
https://doi.org/10.1016/j.micromeso.2016.08.014
Collections
Department of Biology, Article