Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release

Date

2016-11-15

Author

Eren, Zeynep Seda
Tuncer, Sinem
Gezer, Gamze
Yildirim, Leyla Tatar
Banerjee, Sreeparna
Yılmaz, Ayşen

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In this study, celecoxib (CLX), a highly hydrophobic nonsteroidal anti-inflammatory drug with relatively low bioavailability, was used as a model drug to determine loading in different solvents and release properties from silica particles. Hydrothermal synthesis method was used to synthesize SBA-15 particles, which were functionalized by post-synthesis grafting method with (3-Aminopropyl) triethoxysilane (APTES). Additionally, boron doped SBA-15 samples were prepared to generate borosilicate samples. After functionalization, drug loading was carried out in three different solvents: ethanol, methanol and hexane and their effect on drug loading and release properties were examined. Particle morphology and solvent effect on drug loading capacity of silica particles, as well as the effect of pH on drug release were analyzed. For this purpose, SBA-15 particles were characterized by using X-ray Diffraction (XRD), Small Angle X-ray Spectrometry (SAXS), N-2 adsorption-desorption, Fourier Transform Infra-red Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Ultra-Violet Spectrometry (UV-VIS) and Thermogravimetric Analysis (TGA).

Subject Keywords

SBA-15 Particles, Surface Functionalization, Borosilicate, Drug Delivery Systems, Celecoxib

URI

https://hdl.handle.net/11511/36396

Journal

MICROPOROUS AND MESOPOROUS MATERIALS

DOI

https://doi.org/10.1016/j.micromeso.2016.08.014

Collections

Department of Biology, Article

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Inclusion of celecoxib in the SBA-15 mesoporous silica: drug loading and release property Eren, Zeynep Seda; Yılmaz, Ayşen; Department of Chemistry (2016) Mesoporous silica particles have been used to enhance the loading capacity of drugs into the support, increase the solubility of drug and control drug release. In this study, poorly water-soluble, nonsteroidal anti-inflammatory drug with relatively low bioavailability Celecoxib, was used as a model drug in order to determine the drug loading and release properties of silica particles. In order to synthesize SBA15 particles, hydrothermal synthesis method was used, SBA-15 samples were functionalized by post-g...
Surface functionalization of sba-15 particles for celecoxib delivery Gezer, Gamze; Yılmaz, Ayşen; Department of Chemistry (2013) Mesoporous silica particles have been used to enhance the loading capacity of drugs into these particles, increase bioavailability and control drug release. In this study SBA-15 particles were synthesized and functionalized to improve the loading capacity and release rate of drug. Then, drug loading and release process were investigated. Celecoxib was chosen as a model drug which is very hydrophobic. SBA-15 particles were used due to their highly ordered, well-defined mesoporous structure. These particles w...
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Citation Formats

Z. S. Eren, S. Tuncer, G. Gezer, L. T. Yildirim, S. Banerjee, and A. Yılmaz, “Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release,” MICROPOROUS AND MESOPOROUS MATERIALS, pp. 211–223, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36396.