Effect of maternal high fat diet on hypothalamus vacularite of their offspring /

Download
2014
Teker, Hikmet Taner
Obesity is a medical condition that carries increased risk for the onset of metabolic disorders and many other chronic diseases. However, etiology of obesity and how obsegenic traits are emerged remain to be elucidated. Investigations about this issue focused on one of the brain regions, hypothalamus,where energy homeostasis,food intake and appetite are regulated. Under the condition of hypothalamic inflammation and/or because of the passage of toxic substances from the circulating blood to the hypothalamus, hypothalamic cells are disrupted and metabolic deregulations might initiate, risk factors for obesity and other cluster of metabolic disordersmight increase. Recent studies have shown that the maternal obesity and/or obesogenic diet consumption during pregnancy may initiate hypothalamic inflammation which may permanently alter hypothalamic structures and functions in the offspring. Based on evidences that neuro-vascular changes, especially changes in brain blood barrier (BBB) integrity arenot only results in passage of toxic substances from circulating bloods but also may initiate or contribute to hypothalamic inflammation and affect microvessel density. In this study, we investigated changes in BBB integrity of 20 days-old Wistar rat offspring whose mothers were fed with HFD. Our results shows thatoffspringwhose mothers fed with HFD (cafeteria diet) hypothalamicBBB integritywas increased significantly compare to controls.Our results suggest that maternal obesity has impacts on hypothalamicBBB integrity and such changes can inhibit certain crutial signals to reach hypothalamus and initiate cascade of disease conditions as blocking signal homeostasisduring development.

Suggestions

Effects of metformin on olanzapine induced weight gain in male wistar rats: the change of hypothalamic neurohormones involved in body weight regulation
Kurt, Gizem; Yanık, Tülin; Department of Biology (2014)
Obesity, resulting from the extreme weight gain, is one of the biggest health problems nowadays because it causes disruption of the metabolism and metabolic problems, including type 2 diabetes mellitus, dyslipidemia and cardiovascular disease. Atypical (second generation) antipsychotic drugs, which are highly in use, have adverse effects including weight gain. Ongoing researches for the treatment of antipsychotics induced-weight gain are present and one of the promising agents is metformin, an anti-diabetic...
The effects of high cholesterol/high fat diet on endoplasmic reticulum stress and neuronal dysfunction in the hippocampus and cerebral cortex of APOE-/- MICE
Mengi, Naz; Yanık, Tülin; Department of Molecular Biology and Genetics (2019)
Hyperlipidemia is an obesity-associated lipid metabolism disorder with high serum total cholesterol (TC) levels and is known to be a risk factor for neurodegenerative diseases. High-fat diet (HFD) induced elevated inflammation levels accompanied by increased levels of apoptosis markers and decreased levels of synaptic proteins in the hippocampus points out a possible neuronal loss. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) pathway is activated by endoplasmic reticulum (ER) stress. The acti...
Effect of quercetin on mRNA and protein expressions of vitamin D metabolizing CYP27B1 and CYP24A1 in human embryonic kidney cell line (HEK-293)
Durukan, Özlem; Akkulak, Merve; Özhan, Güneş; Evin, Emre; Adalı, Orhan (Wiley, 2018-07-01)
Vitamin D is essential compound for life having role not only in the regulation of calcium metabolism but also in the regulation of cell proliferation, immune responses, cardiovascular homeostasis and nervous system. These wide range of actions occur with the enzymatic conversion of vitamin D to 1a,25-dihydroxyvitamin D by cytochrome P450 enzymes (CYPs). While CYP27B1 provides the synthesis of hormonally active form of Vitamin D, 1,25(OH)2D, CYP24A1 involves in catabolism of vitamin D. Quercetin, as one of ...
Mismatch between obesogenic intrauterine environment and low-fat postnatal diet may confer offspring metabolic advantage
Kışlal, Sezen; Maesner, Claire; Edlow, Andrea G. (2021-08-01)
Objective: Mismatch between a depleted intrauterine environment and a substrate-rich postnatal environment confers an increased risk of offspring obesity and metabolic syndrome. Maternal diet-induced obesity (MATOB) is associated with the same outcomes. These experiments tested the hypothesis that a mismatch between a nutrient-rich intrauterine environment and a low-fat postnatal environment would ameliorate offspring metabolic morbidity.
Early alterations in myocardia and vessels of the diabetic rat heart: an FTIR microspectroscopic study
Toyran, Neslihan; Lasch, Peter; Naumann, Dieter; Turan, Belma; Severcan, Feride (2006-08-01)
Diabetes mellitus is associated with a high incidence and poor prognosis of cardiovascular disease. The aim of the present study was to examine the effect of relatively short-term (5 weeks) Type I diabetes on the left ventricle, the right ventricle and the vessel (vein) on the left ventricle of the myocardium, at molecular level by FTIR (Fourier-transform infrared) microspectroscopy. The rats were categorized into two groups: control group (for the left ventricle myocardium, n = 8; for the right ventricle m...
Citation Formats
H. T. Teker, “Effect of maternal high fat diet on hypothalamus vacularite of their offspring /,” M.S. - Master of Science, Middle East Technical University, 2014.