Orhan Adalı

Department of Biology
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Xenogenic Neural Stem Cell-Derived Extracellular Nanovesicles Modulate Human Mesenchymal Stem Cell Fate and Reconstruct Metabolomic Structure
DERKUŞ, BURAK; Isik, Melis; Eylem, Cemil Can; ERGİN, İREM; Camci, Can Berk; Bilgin, Sila; ELBÜKEN, ÇAĞLAR; ARSLAN, YAVUZ EMRE; Akkulak, Merve; Adalı, Orhan; KIRAN, FADİME; Okesola, Babatunde O.; NEMUTLU, EMİRHAN; EMREGÜL, EMEL (2022-03-01)
Extracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to ...
Association of cholesterol 7 alpha-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population
SEZER, EDA; CAN DEMİRDÖĞEN, BİRSEN; Demirkaya, Seref; Bulut, Giray; Akkulak, Merve; EVİN, EMRE; Adalı, Orhan (2021-09-01)
Background Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7 alpha-hydr...
Cytotoxic Effects of Probiotic Bacteria Lactobacillus acidophilus and Lactobacillus rhamnosus Grown in the Presence of Oleuropein on Human Prostate Cancer Cells
Çelebioğlu, Hasan Ufuk; Erden, Yavuz; Evin, Emre; Çelebi, Busenur; Adalı, Orhan (2020-03-01)
Functional foods are groups of foods that have potentially positive effects on health beyond basic nutrition. Probiotics are beneficial microorganisms, being as a group of functional foods, and when ingested in adequate am...
Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population
Demirdogen, Birsen Can; Micoogullari, Yagmur; Ozcelik, Aysun Turkanoglu; Adalı, Orhan (2020-01-01)
Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury ...
Sanguisorba minor subsp. Balearica inhibit production of cytokines in a chronic model of inflammation induced by complete Freund's adjuvant
Genc, A. I.; Adalı, Orhan; Kul, O.; Ozkan, A. M. Gencler (2019-10-15)
Plant phenolic oleuropein inhibits HT-29 colon cancer cell proliferation through DNA damage, ROS generation and downregulation of xenobiotic metabolizing enzymes
Durmus, E.; KOÇYİĞİT, ABDÜRRAHİM; Adalı, Orhan (2019-07-01)
Ege, Tuba; Ozkan, Ayse Mine Gencler; Sena, Alaattin; Adalı, Orhan (2019-01-01)
This research was designed to determine about the possible potency of medicinal plants Viscum album L. and its major polyphenolic ingredient, o-coumaric acid on rat liver cholesterol and bile acid metabolizing enzymes. Bio...
Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population
Bilgin, Esra; Can Demirdöğen, Birsen; Ozcelik, Aysun Turkanoglu; Demirkaya, Seref; Adalı, Orhan (Informa UK Limited, 2019-01-01)
Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role ...
Effects of folk medicinal plant epilobium hirsutum l. And its ingredient ellagic acid on rat liver bile acid synthesizing cyps in rats
Ege, T.; Gençler-özkan, A.m.; Şen, A.; Adalı, Orhan (2018-12-30)
The phytochemical compounds are used mostly in medicine as alternative medicine. Excessive cholesterol is removed mainly through conversion to bile acids in mammals, cytochromes P450 initiate all quantitatively significant...
Effect of quercetin on mRNA and protein expressions of vitamin D metabolizing CYP27B1 and CYP24A1 in human embryonic kidney cell line (HEK-293)
Akkulak, M.; Evin, E.; Durukan, O.; Ozhan, G.; Adalı, Orhan (2018-07-01)
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