Orhan Adalı

E-mail

bioorhan@metu.edu.tr

Department

Department of Biology

ORCID

0000-0001-8484-1146

Scopus Author ID

6603385719

Web of Science Researcher ID

AAZ-9132-2020

ONKOFETAL CYP2W1 GENİNİN EPİTELYAL-MEZENKİMAL GEÇİŞ BELİRTEÇLERİ ÜZERİNE ETKİLERİ Akkulak, Merve; Durukan, Özlem; Evin, Emre; Adalı, Orhan (2022-10-30) Sitokrom P450 2W1 (CYP2W1) expresyonu, fetal ve tümör dokularında çok yüksek olmasına rağmen sağlıklı yetişkin dokularında saptanamaz veya çok düşüktür. CYP2W1 ekspresyonu, daha agresif tümör fenotipi ile pozitif ilişkili ...
Investigating the role of CYP4X1 gene during brain tumor angiogenesis via RNAi mediated gene repression Durukan, Özlem; Akkulak, Merve; Evin, Emre; Adalı, Orhan (2022-10-30)
Xenogenic Neural Stem Cell-Derived Extracellular Nanovesicles Modulate Human Mesenchymal Stem Cell Fate and Reconstruct Metabolomic Structure DERKUŞ, BURAK; Isik, Melis; Eylem, Cemil Can; ERGİN, İREM; Camci, Can Berk; Bilgin, Sila; ELBÜKEN, ÇAĞLAR; ARSLAN, YAVUZ EMRE; Akkulak, Merve; Adalı, Orhan; KIRAN, FADİME; Okesola, Babatunde O.; NEMUTLU, EMİRHAN; EMREGÜL, EMEL (2022-03-01) Extracellular nanovesicles, particularly exosomes, can deliver their diverse bioactive biomolecular content, including miRNAs, proteins, and lipids, thus providing a context for investigating the capability of exosomes to ...
Association of cholesterol 7 alpha-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population SEZER, EDA; CAN DEMİRDÖĞEN, BİRSEN; Demirkaya, Seref; Bulut, Giray; Akkulak, Merve; EVİN, EMRE; Adalı, Orhan (2021-09-01) Background Patients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7 alpha-hydr...
Cytotoxic Effects of Probiotic Bacteria Lactobacillus acidophilus and Lactobacillus rhamnosus Grown in the Presence of Oleuropein on Human Prostate Cancer Cells Çelebioğlu, Hasan Ufuk; Erden, Yavuz; Evin, Emre; Çelebi, Busenur; Adalı, Orhan (2020-03-01) Functional foods are groups of foods that have potentially positive effects on health beyond basic nutrition. Probiotics are beneficial microorganisms, being as a group of functional foods, and when ingested in adequate am...
Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population Demirdogen, Birsen Can; Micoogullari, Yagmur; Ozcelik, Aysun Turkanoglu; Adalı, Orhan (2020-01-01) Purpose: Soluble epoxide hydrolase (sEH) and microsomal epoxide hydrolase (mEH) both catalyze the metabolism of epoxyeicosatrienoic acids (EETs), lipid signaling molecules that are protective against ischemic brain injury ...
Sanguisorba minor subsp. Balearica inhibit production of cytokines in a chronic model of inflammation induced by complete Freund's adjuvant Genc, A. I.; Adalı, Orhan; Kul, O.; Ozkan, A. M. Gencler (2019-10-15)
Plant phenolic oleuropein inhibits HT-29 colon cancer cell proliferation through DNA damage, ROS generation and downregulation of xenobiotic metabolizing enzymes Durmus, E.; KOÇYİĞİT, ABDÜRRAHİM; Adalı, Orhan (2019-07-01)
Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population Bilgin, Esra; Can Demirdöğen, Birsen; Ozcelik, Aysun Turkanoglu; Demirkaya, Seref; Adalı, Orhan (Informa UK Limited, 2019-01-01) Objectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role ...
EVALUATION OF IN VIVO EFFECTS OF VISCUM ALBUM L. AND ITS CONSTITUENT O-COUMARIC ACID ON BILE ACID SYNTHESIZING CYPS Ege, Tuba; Ozkan, Ayse Mine Gencler; Sena, Alaattin; Adalı, Orhan (2019-01-01) This research was designed to determine about the possible potency of medicinal plants Viscum album L. and its major polyphenolic ingredient, o-coumaric acid on rat liver cholesterol and bile acid metabolizing enzymes. Bio...

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