Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic

Date

2015-12-25

Author

Özcengiz, Gülay

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 United States License.

Item Usage Stats

407
views

0
downloads

Bacillus subtilis has the capacity to produce more than two dozen bioactive compounds with an amazing variety of chemical structures. Among them, bacilysin is a non-ribosomally synthesized dipeptide antibiotic consisting of L-alanine residue at the N terminus and a non-proteinogenic amino acid, L-anticapsin, at the C terminus. In spite of its simple structure, it is active against a wide range of bacteria and fungi. As a potent antimicrobial agent, we briefly review the biochemistry and genetics as well as the regulation of bacilysin biosynthesis within the frame of peptide pheromones-based control of secondary activities. Biological functions of bacilysin in the producer B. subtilis beyond its antimicrobial activity as well as potential biotechnological use of the biosynthetic enzyme L-amino acid ligase (Lal) are also discussed.

Subject Keywords

Bacterıum Bacıllus-Subtılıs, Amıno-Acıd Lıgase, Peptide Antibiotics, Competence Development, Insertional Mutations, Staphylococcus-Aureus, Stationary-Phase, Quorum Response, Sporulatıon, Anticapsin

URI

https://hdl.handle.net/11511/28631

Journal

New Biotechnology

DOI

https://doi.org/10.1016/j.nbt.2015.01.006

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Optimization of synthetic route to PNA-T-OH monomers ALPTÜRK, ONUR; YEŞILBAŞ, SEVCAN; SARIOĞLU, GÖZDE; KARAÇAYLI, ASLI; SAYLAM, AYTÜL; Özçubukçu, Salih (2018-01-01) Peptide nucleic acids are synthetic molecules crafted to mimic natural nucleic acids, and thus, they are widely utilized in many chemical, and, biomedical applications. Although there exist many approaches to synthesize monomers to date, there is still room to improve these methodologies. With this motivation, we compared some widely utilized synthetic routes to obtain N-Boc-PNA-T-OH, and N-Fmoc-PNA-T-OH. Our results indicate that N-Bocethylenediamine is the most pivotal intermediate in the chemistry of PNA...
Synthesis of metal binding artificial amino acids Eşan, Gözde; Özçubukçu, Salih; Department of Chemistry (2014) A large variety of peptides with different physical and chemical properties can be acquired by using different amino acids. Through chemical peptide synthesis, utilizing unnatural synthetic amino acids beside 21 natural amino acids, divergent peptides can also be obtained easily. Specifically amino acid and peptide conjugates of metals have received considerable attention due to their important role in many biological processes with unique structural properties. Moreover, it is well known that some metal io...
Development of new synthetic methodologies for indole derivatives Kılıklı, Ahmet Alper; Balcı, Metin; Department of Chemistry (2010) Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besi...
Synthesis of new pyrrole derivatives from npropargylic β-enaminones Kanova, Nilay; Zora, Metin; Department of Chemistry (2020) Heterocyclic compounds are a momentous area of synthetic organic chemistry because of their existence in bioactive molecules. Pyrroles, which are one of the most important classes of heterocyclic compounds, have great importance in pharmaceutical chemistry due to their biological activities. Having these characteristics makes them drawn attention of most chemists to develop new methodologies for the synthesis of pyrroles. Recently, the cyclization of Npropargylic β-enaminones has been used for the synthesis...
Production and biochemical characterization of polyphenol oxidase from thermomyces lanuginosus Astarcı, Erhan; Bakır, Ufuk; Ögel, Zümrüt B.; Department of Biotechnology (2003) Polyphenol oxidases are enzymes that catalyze the oxidation of certain phenolic substrates to quinones in the presence of molecular oxygen. Polyphenol oxidases are widely used in several applications. In food industry, they are used for enhancement of flavor in coffee, tea and cocoa production, and determination of food quality. In medicine, they have several uses in treatments of Parkinson̕s disease, phenlyketonurea and leukemia. In wastewater treatment, they are used for the removal of phenolic pollutants...

Citation Formats

G. Özcengiz, “Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic,” New Biotechnology, pp. 612–619, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/28631.