Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic

Date

2015-12-25

Author

Özcengiz, Gülay

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Bacillus subtilis has the capacity to produce more than two dozen bioactive compounds with an amazing variety of chemical structures. Among them, bacilysin is a non-ribosomally synthesized dipeptide antibiotic consisting of L-alanine residue at the N terminus and a non-proteinogenic amino acid, L-anticapsin, at the C terminus. In spite of its simple structure, it is active against a wide range of bacteria and fungi. As a potent antimicrobial agent, we briefly review the biochemistry and genetics as well as the regulation of bacilysin biosynthesis within the frame of peptide pheromones-based control of secondary activities. Biological functions of bacilysin in the producer B. subtilis beyond its antimicrobial activity as well as potential biotechnological use of the biosynthetic enzyme L-amino acid ligase (Lal) are also discussed.

Subject Keywords

Bacterıum Bacıllus-Subtılıs, Amıno-Acıd Lıgase, Peptide Antibiotics, Competence Development, Insertional Mutations, Staphylococcus-Aureus, Stationary-Phase, Quorum Response, Sporulatıon, Anticapsin

URI

https://hdl.handle.net/11511/28631

Journal

New Biotechnology

DOI

https://doi.org/10.1016/j.nbt.2015.01.006

Collections

Department of Biology, Article

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Citation Formats

G. Özcengiz, “Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic,” New Biotechnology, pp. 612–619, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/28631.