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Effect of oxygen plasma on surface properties and biocompatibility of PLGA films

In this study, poly(D, L-lactide-co-glycolide) (PLGA) films were prepared by solvent casting method and the surfaces of the films were modified by application of oxygen plasma. A radio frequency (RF) generator working at 13.56 MHz was used to create plasma, and powers at different levels changing between 20 and 300 W were applied. The variations in chemistry, topography and surface free energy (SFE) of the films were investigated by electron spectroscopy for chemical analysis (ESCA), atomic force microscopy (AFM) and goniometer, respectively. The cell-material interactions of the modified samples were evaluated by cell culture tests using 3T3 fibroblast cell line.