Biodegradable nanomats produced by electrospinning: Expanding multifunctionality and potential for tissue engineering

Download

Date

2007-03-01

Author

Ashammakhi, N.
Ndreu, A.
Piras, A. M.
Nikkola, L.
Sindelar, T.
Ylikauppila, H.
Harlin, A.
Gomes, M. E.
Neves, N. M.
Chiellini, E.
Chiellini, F.
Hasırcı, Vasıf Nejat
Redl, H.
Reis, R. L.

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

139
views

0
downloads

With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to explore the spinning of submicron fibers from biodegradable polymers and to develop also multifunctional drug-releasing and bioactive scaffolds. Various factors can affect the properties of resulting nanostructures that can be classified into three main categories, namely: (1) Substrate related, (2) Apparatus related, and (3) Environment related factors. Developed n-scaffolds were tested for their cytocompatibility using different cell models and were seeded with cells for to develop tissue engineering constructs. Most importantly, studies have looked at the potential of using n-scaffolds for the development of blood vessels. There is a large area ahead for further applications and development of the field. For instance, multifunctional scaffolds that can be used as controlled delivery system do have a potential and have yet to be investigated for engineering of various tissues. So far, in vivo data on n-scaffolds are scarce, but in future reports are expected to emerge. With the convergence of the fields of nanotechnology, drug release and tissue engineering, new solutions could be found for the current limitations of tissue engineering scaffolds, which may enhance their functionality upon in vivo implantation. In this paper electrospinning process, factors affecting it, used polymers, developed n-scaffolds and their characterization are reviewed with focus on application in tissue engineering.

Subject Keywords

Drug Release, Electrospinning, Multifunctional, Nanofiber, Nanotechnology, Regeneration, Scaffold, Tissue Engineering

URI

https://hdl.handle.net/11511/32623

Journal

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

DOI

https://doi.org/10.1166/jnn.2007.485

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Bioactive Surface Design Based on Functional Composite Electrospun Nanofibers for Biomolecule Immobilization and Biosensor Applications Uzun, Sema Demirci; Kayaci, Fatma; UYAR, Tamer; TİMUR, SUNA; Toppare, Levent Kamil (2014-04-09) The combination of nanomaterials and conducting polymers attracted remarkable attention for development of new immobilization matrices for enzymes. Hereby, an efficient surface design was investigated by modifying the graphite rod electrode surfaces with one-step electrospun nylon 6,6 nanofibers or 4% (w/w) multiwalled carbon nanotubes (MWCNTs) incorporating nylon 6,6 nanofibers (nylon 6,6/4MWCNT). High-resolution transmission electron microscopy study confirmed the successful incorporation of the MWCNTs in...
Nanobiomaterials: a review of the existing science and technology, and new approaches Hasırcı, Vasıf Nejat; Zorlutuna, P.; Ndreu, A.; Yilgor, P.; Basmanav, F. B.; Aydin, E. (2006-01-01) Nanotechnology has made great strides forward in the creation of new surfaces, new materials and new forms which also find application in the biomedical field. Traditional biomedical applications started benefiting from the use nanotechnology in an array of areas, such as biosensors, tissue engineering, controlled release systems, intelligent systems and nanocomposites used in implant design. In this manuscript a review of developments in these areas will be provided along with some applications from our la...
Amino Acid And Peptide Based Gels Aykent, Güzide; Özçubukçu, Salih; Department of Chemistry (2021-2-12) Self-assembling peptides and amino acid derivatives are becoming an emerging field especially in last decades. Especially for their usage in biomedical applications, tissue engineering and drug delivery, extensive research are being done. Large variety of peptides with different physical and chemical properties were acquired by using different amino acids and their sequences. As a more easily synthesized and bio-inspired alternative materials to the compounds used nowadays for organic electronic devices, ge...
Decellularized Bone Extracellular Matrix-Coated Electrospun PBAT Microfibrous Membranes with Cell Instructive Ability and Improved Bone Tissue Forming Capacity Karakaya, Ece; Erdoğan, Yaşar Kemal; Arslan, Tugba Sezgin; Arslan, Yavuz Emre; Odabaş, Sedat; Ercan, Batur; Emregül, Emel; Derkuş, Burak (2022-09-01) Current approaches to develop bone tissue engineering scaffolds have some limitations and shortcomings. They mainly suffer from combining mechanical stability and bioactivity on the same platform. Synthetic polymers are able to produce mechanically stable sturctures with fibrous morphology when they are electrospun, however, they cannot exhibit bioactivity, which is crucial for tissue engineering and regenerative medicine. One current strategy to bring bioactivity in synthetic materials is to combine extrac...
Stability analysis of graphene nanoribbons by molecular dynamics simulations Dugan, N.; Erkoç, Şakir (Wiley, 2008-04-01) In this work, stability of graphene nanoribbons are investigated using molecular dynamics. Simulations include heating armchair and zigzag-edged nanoribbons of widths varying between one and nine hexagonal rings until the bonds between carbon atoms start to break. Breaking temperatures and binding energies per atom for different widths are presented for both armchair and zigzag-edged cases. A nontrivial relation between stability and width is observed and discussed.

Citation Formats

N. Ashammakhi et al., “Biodegradable nanomats produced by electrospinning: Expanding multifunctionality and potential for tissue engineering,” JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, pp. 862–882, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32623.