THE USE OF LIPOSOMES IN THE INVESTIGATION OF MECHANISMS OF ASBESTOS DAMAGE

1994-08-15
Asbestos-induced cell damage is initiated by a reaction at the plasma membrane. The effect of chrysotile (which is more hemolytic and releases more silicic acid than other types of asbestos) on permeability changes of liposomes has been investigated. The destabilizing effect rises when the amount of chrysotile is increased. Silicon dioxide is one major constituent which could be a hemolytic agent, and a cause of damage. It also caused an increase of permeability of liposomes.
EXPERIENTIA

Suggestions

Effect of cortex stiffness variation on cleavage in animal cells
AKKAS, N; KERMANIAN, M (1993-09-29)
Cytokinesis is the division of the cytoplasm and the plasma membrane into two. Nuclear division and cytokinesis take a relatively short time to happen in animal cells in which cytokinesis takes place by means of furrowing. Here we consider the cleavage of the animal cells only. Although the basic division mechanisms appear to be similar in all animal cells, the divisions that take place during early embryonic development, which are termed as cleavages, are not exactly the same as those that occur later. In ...
Anticancer activity of chlorpromazine on U266 multiple myeloma cell line
Güleç, Aliye Ezgi; Özen, Can; Özçubukçu, Salih; Department of Biochemistry (2017)
Multiple Myeloma (MM) is the second most common hematological malignancy caused by malignant growth of plasma B cells. It accounts for 10% of deaths from blood cancers. Although introduction of new drugs has significantly increased the success of chemotherapy, MM remains as an incurable disease with a high relapse rate. Drug repositioning, finding new uses for approved drugs, is a frequently used strategy for the discovery of new chemotherapeutic agents. Since already approved drugs are used, the cost and t...
An update on molecular biology and drug resistance mechanisms of multiple myeloma
Mutlu, Pelin; Gündüz, Ufuk (Elsevier BV, 2015-12)
Multiple myeloma (MM), a neoplasm of plasma cells, is the second most common hematological malignancy. Incidance rates increase after age 40. MM is most commonly seen in men and African-American population. There are several factors to this, such as obesity, environmental factors, family history, genetic factors and monoclonal gammopathies of undetermined significance (MGUS) that have been implicated as potentially etiologic. Development of MM involves a series of complex molecular events, including chromos...
The facile synthesis of cyclopentanoid antibiotic kjellmanianone
Demir, Ayhan Sıtkı; Tanyeli, Cihangir; Gulbeyaz, V; Akgul, H (1996-01-01)
The synthesis of cyclopentanoid antibiotic Kjellmanianone is described in this study. The C-acylation of lithium enolates of 3-Methoxycyclopentenone by N-carbomethoxyimidazole or methylcyanoformate beta-ketoester, which when oxidized with Mn(III) acetate produces kjellmanianone in good yield.
Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG
Yildiz, Soner; Alpdundar, Esin; Gungor, Bilgi; Kahraman, Tamer; Bayyurt, Banu; GÜRSEL, İHSAN; Gürsel, Mayda (2015-04-01)
Recognition of pathogen-derived nucleic acids by immune cells is critical for the activation of protective innate immune responses. Bacterial cyclic dinucleotides (CDNs) are small nucleic acids that are directly recognized by the cytosolic DNA sensor STING (stimulator of IFN genes), initiating a response characterized by proinflammatory cytokine and type I IFN production. Strategies to improve the immune stimulatory activities of CDNs can further their potential for clinical development. Here, we demonstrat...
Citation Formats
G. ERDOGDU and V. N. Hasırcı, “THE USE OF LIPOSOMES IN THE INVESTIGATION OF MECHANISMS OF ASBESTOS DAMAGE,” EXPERIENTIA, pp. 785–787, 1994, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31833.