A DEP-Based Lab-On-A-Chip System For The Detection Of Multidrug Resistance In K562 Leukemia Cells

Yalçın, Yağmur Demircan
Özkayar, Gürkan
Özgür, Ebru
Gündüz, Ufuk
Külah, Haluk
This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.


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Highly-sensitive and fast detection of human telomeric G-Quadruplex DNA based on a hemin-conjugated fluorescent metal-organic framework platform
Javan Kouzegaran, Vahid; Farhadi, Khalil; Forough, Mehrdad; Bahram, Morteza; Persil Çetinkol, Özgül (Elsevier BV, 2021-04-15)
© 2021 Elsevier B.V.The formation of G-quadruplex (G4) structures in Human telomeric DNA (H-Telo) has been demonstrated to inhibit the activity of telomerase enzyme that is associated with the proliferation of many cancer cells. Accordingly, G-quadruplex structures have become one of the well-established targets in anticancer therapeutic strategies. And, the development of simple and selective detection platforms for G4 structures has become a significant focus of research in recent years. In this study, a ...
Citation Formats
Y. D. Yalçın, G. Özkayar, E. Özgür, U. Gündüz, and H. Külah, “A DEP-Based Lab-On-A-Chip System For The Detection Of Multidrug Resistance In K562 Leukemia Cells,” 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32390.