A DEP-Based Lab-On-A-Chip System For The Detection Of Multidrug Resistance In K562 Leukemia Cells

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2016-06-09
Yalçın, Yağmur Demircan
Özkayar, Gürkan
Özgür, Ebru
Gündüz, Ufuk
Külah, Haluk
This study presents a DEP-based lab-on-a-chip (LOC) system for label-free detection of multidrug resistant (MDR) K562 leukemia cells in a cell mixture, consisting of red blood cells (RBCs) and MDR-K562 cells, for the first time in the literature. The system consists of 2 consecutive DEP units, one for the depletion of RBCs and the other for capturing of MDR-K562 cells. RBCs are depleted by 60% in the first unit. In the second unit, MDR-K562 cell detection is performed with 100% selectivity at a flow rate of 10 μl/min and at 20 Vpp in a cell mixture, containing less than 25% MDR-K562 cells.
Citation Formats
Y. D. Yalçın, G. Özkayar, E. Özgür, U. Gündüz, and H. Külah, “A DEP-Based Lab-On-A-Chip System For The Detection Of Multidrug Resistance In K562 Leukemia Cells,” 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32390.