Unilateral deep brain stimulation suppresses alpha and beta oscillations in sensorimotor cortices

Abbasi, Omid
Hirschmann, Jan
Storzer, Lena
Özkurt, Tolga Esat
Elben, Saskia
Vesper, Jan
Wojtecki, Lars
Schmitz, Georg
Schnitzler, Alfons
Butz, Markus
Deep brain stimulation (DBS) is an established therapy to treat motor symptoms in movement disorders such as Parkinson's disease (PD). The mechanisms leading to the high therapeutic effectiveness of DBS are poorly understood so far, but modulation of oscillatory activity is likely to play an important role. Thus, investigating the effect of DBS on cortical oscillatory activity can help clarifying the neurophysiological mechanisms of DBS. Here, we aimed at scrutinizing changes of cortical oscillatory activity by DBS at different frequencies using magneto-encephalography (MEG).


A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease
Hirschmann, Jan; Hartmann, Christian J.; Butz, Markus; Hoogenboom, Nienke; Özkurt, Tolga Esat; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2013-12-01)
Electrophysiological studies suggest that rest tremor in Parkinson's disease is associated with an alteration of oscillatory activity. Although it is well known that tremor depends on cortico-muscular coupling, it is unclear whether synchronization within and between brain areas is specifically related to the presence and severity of tremor. To tackle this longstanding issue, we took advantage of naturally occurring spontaneous tremor fluctuations and investigated cerebral synchronization in the presence an...
Differential modulation of STN-cortical and cortico-muscular coherence by movement and levodopa in Parkinson's disease
Hirschmann, J.; Özkurt, Tolga Esat; Butz, M.; Homburger, M.; Elben, S.; Hartmann, C. J.; Vesper, J.; Wojtecki, L.; Schnitzler, A. (2013-03-01)
Previous research suggests that oscillatory coupling between cortex, basal ganglia and muscles plays an important role in motor behavior. Furthermore, there is evidence that oscillatory coupling is altered in patients with movement disorders such as Parkinson's disease (PD).
Thalamic GABA levels and occupational manganese neurotoxicity: Association with exposure levels and brain MRI
Ma, Ruoyun E.; Ward, Eric J.; Yeh, Chien-Lin; Snyder, Sandy; Long, Zaiyang; Gökalp Yavuz, Fulya; Zauber, S. Elizabeth; Dydak, Ulrike (Elsevier BV, 2018-1)
Excessive occupational exposure to Manganese (Mn) has been associated with clinical symptoms resembling idiopathic Parkinson's disease (IPD), impairing cognitive and motor functions. Several studies point towards an involvement of the brain neurotransmitter system in Mn intoxication, which is hypothesized to be disturbed prior to onset of symptoms. Edited Magnetic Resonance Spectroscopy (MRS) offers the unique possibility to measure gamma-amminobutyric acid (GABA) and other neuro-metabolites in vivo non-inv...
Phase validation of neurotoxic animal models of Parkinson's disease
Telkes, İlknur; Jakubowska Doğru, Ewa; Department of Medical Informatics (2012)
Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic nigral neurons and striatal dopamine resulting in serious motor deficits but also some non-motor anomalies. Animal models of human neurodegenerative diseases are essential for better understanding their pathogenesis and developing efficient therapeutic tools. There are many different PD models, however, none of them is fully reproducing all the symptoms of the disease. In addition, different investigators use different behavio...
Parkinsonian Rest Tremor Is Associated With Modulations of Subthalamic High-Frequency Oscillations
Hirschmann, Jan; Butz, Markus; Hartmann, Christian J.; Hoogenboom, Nienke; Özkurt, Tolga Esat; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2016-10-01)
BackgroundHigh frequency oscillations (>200 Hz) have been observed in the basal ganglia of PD patients and were shown to be modulated by the administration of levodopa and voluntary movement.
Citation Formats
O. Abbasi et al., “Unilateral deep brain stimulation suppresses alpha and beta oscillations in sensorimotor cortices,” NEUROIMAGE, pp. 201–207, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32487.