Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease

Date

2011-04-01

Author

Hirschmann, J.
Özkurt, Tolga Esat
Butz, M.
Homburger, M.
Elben, S.
Hartmann, C. J.
Vesper, J.
Wojtecki, L.
Schnitzler, A.

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Neuronal oscillations are assumed to play a pivotal role in the pathophysiology of Parkinson's disease (PD). Neurons in the subthalamic nucleus (STN) generate oscillations which are coupled to rhythmic population activity both in other basal ganglia nuclei and cortical areas.

Subject Keywords

Parkinson's disease, Magnetoencephalography, Subthalamic nucleus, Functional connectivity, Oscillations, Coherence, SIGNAL SPACE SEPARATION, PRIMARY MOTOR CORTEX, SUPERIOR TEMPORAL GYRUS, SUBTHALAMIC NUCLEUS, BASAL GANGLIA, CEREBRAL-CORTEX, RHESUS-MONKEY, FUNCTIONAL CONNECTIVITY, PHYSIOLOGICAL TREMOR, RESTING TREMOR

URI

https://hdl.handle.net/11511/97047

Journal

NEUROIMAGE

DOI

https://doi.org/10.1016/j.neuroimage.2010.11.063

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Graduate School of Informatics, Article

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High frequency oscillations in the subthalamic nucleus: A neurophysiological marker of the motor state in Parkinson's disease Özkurt, Tolga Esat; Butz, Markus; Homburger, Melanie; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2011-06-01) Increasing evidence suggests that abnormal oscillatory activity in basal ganglia and cortex plays a pivotal role in the pathophysiology of Parkinson's disease. Recordings of local field potentials from subthalamic nucleus of patients undergoing deep brain stimulation have focused on oscillations occurring at frequencies below 100 Hz in the alpha, beta and gamma range and suggested that, in particular, an increase of beta band oscillations underlies slowing of movement in Parkinson's disease. Recent findings...
A direct relationship between oscillatory subthalamic nucleus-cortex coupling and rest tremor in Parkinson's disease Hirschmann, Jan; Hartmann, Christian J.; Butz, Markus; Hoogenboom, Nienke; Özkurt, Tolga Esat; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schnitzler, Alfons (2013-12-01) Electrophysiological studies suggest that rest tremor in Parkinson's disease is associated with an alteration of oscillatory activity. Although it is well known that tremor depends on cortico-muscular coupling, it is unclear whether synchronization within and between brain areas is specifically related to the presence and severity of tremor. To tackle this longstanding issue, we took advantage of naturally occurring spontaneous tremor fluctuations and investigated cerebral synchronization in the presence an...
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Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington's disease Paraskevopoulou, Foteini; Parvizi, Poorya; Senger, Gokce; Tunçbağ, Nurcan; Rosenmund, Christian; Yildirim, Ferah (2021-05-11) Transcriptional dysregulation in Huntington's disease (HD) causes functional deficits in striatal neurons. Here, we performed Patchsequencing (Patch-seq) in an in vitro HD model to investigate the effects of mutant Huntingtin (Htt) on synaptic transmission and gene transcription in single striatal neurons. We found that expression of mutant Htt decreased the synaptic output of striatal neurons in a cell autonomous fashion and identified a number of genes whose dysregulation was correlated with physiological...
Unilateral deep brain stimulation suppresses alpha and beta oscillations in sensorimotor cortices Abbasi, Omid; Hirschmann, Jan; Storzer, Lena; Özkurt, Tolga Esat; Elben, Saskia; Vesper, Jan; Wojtecki, Lars; Schmitz, Georg; Schnitzler, Alfons; Butz, Markus (2018-07-01) Deep brain stimulation (DBS) is an established therapy to treat motor symptoms in movement disorders such as Parkinson's disease (PD). The mechanisms leading to the high therapeutic effectiveness of DBS are poorly understood so far, but modulation of oscillatory activity is likely to play an important role. Thus, investigating the effect of DBS on cortical oscillatory activity can help clarifying the neurophysiological mechanisms of DBS. Here, we aimed at scrutinizing changes of cortical oscillatory activit...

Citation Formats

J. Hirschmann et al., “Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson’s disease,” NEUROIMAGE, vol. 55, no. 3, pp. 1159–1168, 2011, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/97047.