Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia

Date

2015-10-01

Author

Jaros, Julian A.
Rahmoune, Hassan
Wesseling, Hendrik
Leweke, F. Markus
Özcan Kabasakal, Süreyya
Guest, Paul C.
Bahn, Sabine

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

55
views

0
downloads

Purpose Previous studies have shown that blood serum phosphoproteins are altered in schizophrenia patients in comparison to controls. However, it is not known whether phosphoproteins are also changed in response to treatment with antipsychotics.

Subject Keywords

Biomarker, Drug response, Monitoring, Proteomics, Serum

URI

https://hdl.handle.net/11511/33319

Journal

PROTEOMICS CLINICAL APPLICATIONS

DOI

https://doi.org/10.1002/prca.201400148

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

Effects of risperidone treatment on the expression of hypothalamic neuropeptide in appetite regulation in Wistar rats Kursungoz, Canan; AK, MEHMET; Yanık, Tülin (2015-01-30) Although the use of atypical antipsychotic drugs has been successful in the treatment of schizophrenia, they can cause some complications in the long-term use, including weight gain. Patients using these drugs tend to disrupt treatment primarily due to side effects. The atypical antipsychotic mechanism of action regulates a number of highly disrupted neurotransmitter pathways in the brains of psychotic patients but may also cause impairment of neurohorrnonal pathways in different brain areas. In this study,...
Effect of arachidonic acid on specific binding of [H-3]naloxone to opioid receptors Apaydin, S; Öktem, Hüseyin Avni (2000-01-01) The effects of arachidonic acid (AA) on binding of [H-3]naloxone to the agonist and antagonist configurations of opioid receptors were investigated in rat brain. Equilibrium binding parameters of the agonist and antagonist configurations of the receptors were evaluated from homologue displacement data in the presence or absence of AA. Addition of AA at a concentration of 0.6 mM (1.5 mu mole/mg of protein) reduced by 22% and 53% the maximal number of binding sites (B-max) respectively in the absence or prese...
Effect of cobalt-60 (gamma radiation) on multidrug-resistant multiple myeloma cell lines Mutlu, Pelin; Ural, A. Ugur; Avcu, Ferit; Dirican, Bahar; Beyzadeoglu, Murat; Gündüz, Ufuk (2011-07-01) Emergence of resistance to chemotherapy and radiotherapy is a major obstacle for the successful treatment of MM (multiple myeloma). Prednisone, vincristine and melphalan are commonly used chemotherapeutic agents for the treatment of MM. In the current study, we examined the presence of possible cross-resistance between these drugs and gamma (gamma) radiation. Prednisone, vincristine and melphalan resistant RPMI-8226 and U-266 MM cells were generated by stepwise increasing concentrations of the drugs. The se...
Effects of human granulocyte-colony stimulating factor on fracture healing in rats Bozlar, M; Aslan, B; Kalaci, A; Baktiroglu, L; Yanat, AN; Tasci, A (2005-08-01) Objective: Granulocyte colony stimulation factor (G-CSF) is generally used to prevent and cure the neutropenia associated with chemotherapy and bone marrow transplantation. In addition to its effects on neutrophil function, G-CSF was found to have the characteristic of modulating the cytokines in the inflammatory response. Then, the question to answer is whether it has any effect on fracture healing and to what extent? In this study, we test the effects of G-CSF on the healing of tibia fracture in a rat model.
Effects of early postnatal alcohol exposure on the developing retinogeniculate projections in C57BL/6 mice DURSUN, İLKNUR; Jakubowska-Dogru, Ewa; Elibol-Can, Birsen; van der List, Deborah; Chapman, Barbara; Qi, Lihong; Berman, Robert F. (Elsevier BV, 2013-05-01) Previous studies on the adverse effects of perinatal exposure to ethanol (EtOH) on the developing visual system mainly focused on retinal and optic nerve morphology. The aim of the present study was to investigate whether earlier reported retinal and optic nerve changes are accompanied by anomalies in eye-specific fiber segregation in the dorsal lateral geniculate nucleus (dLGN). C57BL/6 mice pups were exposed to ethanol by intragastric intubation at either 3 or 4 g/kg from postnatal days (PD) 3-10, the thi...

Citation Formats

J. A. Jaros et al., “Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia,” PROTEOMICS CLINICAL APPLICATIONS, pp. 907–916, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/33319.