ALCAM (Activated Leukocyte Cell Adhesion Molecule)

Download

index.pdf

Date

2018-01-01

Author

Yavuz, Esra
ÖYKEN, MERVE
Erson Bensan, Ayşe Elif

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

196
views

91
downloads

ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166 (cluster of differentiation 166), is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain.

Subject Keywords

ALCAM, CD166, Cell adhesion

URI

https://hdl.handle.net/11511/35005

Journal

Atlas of Genetics and Cytogenetics in Oncology and Haematology

DOI

https://doi.org/10.4267/2042/68876

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2 Huebner, Kerstin; et. al. (2022-08-01) In cancer, the activating transcription factor 2 (ATF2) has pleiotropic functions in cellular responses to growth stimuli, damage, or inflammation. Due to only limited studies, the significance of ATF2 in colorectal cancer (CRC) is not well understood. We report that low ATF2 levels correlated with worse prognosis and tumor aggressiveness in CRC patients. NanoString gene expression and ChIP analysis confirmed trophoblast cell surface antigen 2 (TROP2) as a novel inhibitory ATF2 target gene. This inverse cor...
Investigation of the inflammatory pathways in spontaneously differentiating Caco-2 cells Astarcı, Erhan; Banerjee, Sreeparna; Çoruh, Nursen; Department of Biochemistry (2011) Intestinal epithelial differentiation entails the formation of highly specialized cells with specific absorptive, secretory, digestive and immune functions. Cell-cell and cell-microenvironment interactions appear to be crucial in determining the outcome of the differentiation process. Using the Caco-2 cell line that can undergo spontaneous differentiation when grown past confluency, we observed a loss of VCAM1 (vascular cell adhesion molecule-1) expression while ICAM1 (intercellular cell adhesion molecule-1...
EGFR (Epidermal Growth Factor Receptor) Hatil, Ayca Circir; Çiçek, Esra; Öyken, Merve; Erson Bensan, Ayşe Elif (2020-01-01) © 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), a...
Loss of the Nuclear Envelope Protein LAP1B Disrupts the Myogenic Differentiation of Patient-Derived Fibroblasts Kayman Kürekçi, Gülsüm; Acar, Aybar Can; Dinçer, Pervin R. (2022-11-01) Lamina-associated polypeptide 1 (LAP1) is a ubiquitously expressed inner nuclear membrane protein encoded by TOR1AIP1, and presents as two isoforms in humans, LAP1B and LAP1C. While loss of both isoforms results in a multisystemic progeroid-like syndrome, specific loss of LAP1B causes muscular dystrophy and cardiomyopathy, suggesting that LAP1B has a critical role in striated muscle. To gain more insight into the molecular pathophysiology underlying muscular dystrophy caused by LAP1B, we established a patie...
Design of a sequence based miRNA clustering method; analysis of fungal miRNAs and host organism target genes Narcı, Kübra; Akkaya, Mahinur S.; Oğul, Hasan; Department of Bioinformatics (2014) MicroRNAs are small non-coding RNA molecules which contain 21-25 nucleotides, and function in post transcriptional regulation by inhibiting the translation of mRNA targets. miRNAs typically affect gene regulation by forming composite feed forward circuits (cFFCs) which also comprise a transcription factor (TF) and a target gene. By analyzing these cFFCs, the contribution of miRNAs in altering TF networks can be revealed. These contributions could either be the de-escalation of the target gene repertoire or ...

Citation Formats

E. Yavuz, M. ÖYKEN, and A. E. Erson Bensan, “ALCAM (Activated Leukocyte Cell Adhesion Molecule),” Atlas of Genetics and Cytogenetics in Oncology and Haematology, pp. 87–92, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/35005.