ALCAM (Activated Leukocyte Cell Adhesion Molecule)

Yavuz, Esra
Erson Bensan, Ayşe Elif
ALCAM (Activated Leukocyte Cell Adhesion Molecule), also known as CD166 (cluster of differentiation 166), is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain.
Atlas of Genetics and Cytogenetics in Oncology and Haematology


Investigation of the inflammatory pathways in spontaneously differentiating Caco-2 cells
Astarcı, Erhan; Banerjee, Sreeparna; Çoruh, Nursen; Department of Biochemistry (2011)
Intestinal epithelial differentiation entails the formation of highly specialized cells with specific absorptive, secretory, digestive and immune functions. Cell-cell and cell-microenvironment interactions appear to be crucial in determining the outcome of the differentiation process. Using the Caco-2 cell line that can undergo spontaneous differentiation when grown past confluency, we observed a loss of VCAM1 (vascular cell adhesion molecule-1) expression while ICAM1 (intercellular cell adhesion molecule-1...
EGFR (Epidermal Growth Factor Receptor)
Hatil, Ayca Circir; Çiçek, Esra; Öyken, Merve; Erson Bensan, Ayşe Elif (2020-01-01)
© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.ERBB family member epidermal receptor tyrosine kinase (EGFR) is composed of 28 exons and 27 introns. EGFR codes for 11 transcripts and 8 of them are protein coding. EGFR is a transmembrane glycoprotein that can be activated by several different ligands such as epidermal growth factor (EGF), transforming growth factor-alpha (TGFA), heparin-binding EGF-like growth factor (HBEGF), betacellulin (BTC), amphiregulin (AREG), epiregulin (EREG), a...
Design of a sequence based miRNA clustering method; analysis of fungal miRNAs and host organism target genes
Narcı, Kübra; Akkaya, Mahinur S.; Oğul, Hasan; Department of Bioinformatics (2014)
MicroRNAs are small non-coding RNA molecules which contain 21-25 nucleotides, and function in post transcriptional regulation by inhibiting the translation of mRNA targets. miRNAs typically affect gene regulation by forming composite feed forward circuits (cFFCs) which also comprise a transcription factor (TF) and a target gene. By analyzing these cFFCs, the contribution of miRNAs in altering TF networks can be revealed. These contributions could either be the de-escalation of the target gene repertoire or ...
Loss of the Nuclear Envelope Protein LAP1B Disrupts the Myogenic Differentiation of Patient-Derived Fibroblasts
Kayman Kürekçi, Gülsüm; Acar, Aybar Can; Dinçer, Pervin R. (2022-11-01)
Lamina-associated polypeptide 1 (LAP1) is a ubiquitously expressed inner nuclear membrane protein encoded by TOR1AIP1, and presents as two isoforms in humans, LAP1B and LAP1C. While loss of both isoforms results in a multisystemic progeroid-like syndrome, specific loss of LAP1B causes muscular dystrophy and cardiomyopathy, suggesting that LAP1B has a critical role in striated muscle. To gain more insight into the molecular pathophysiology underlying muscular dystrophy caused by LAP1B, we established a patie...
RanGTP induces an effector gradient of XCTK2 and importin alpha/beta for spindle microtubule cross-linking
Ems-McClung, Stephanie C.; Emch, Mackenzie; Zhang, Stephanie; Mahnoor, Serena; Weaver, Lesley N.; Walczak, Claire E. (Rockefeller University Press, 2020-02-03)
High RanGTP around chromatin is important for governing spindle assembly during meiosis and mitosis by releasing the inhibitory effects of importin alpha/beta Here we examine how the Ran gradient regulates Kinesin-14 function to control spindle organization. We show that Xenopus Kinesin-14, XCTK2, and importin alpha/beta form an effector gradient that is highest at the poles and diminishes toward the chromatin, which is opposite the RanGTP gradient. Importin alpha and beta preferentially inhibit XCTK2 antip...
Citation Formats
E. Yavuz, M. ÖYKEN, and A. E. Erson Bensan, “ALCAM (Activated Leukocyte Cell Adhesion Molecule),” Atlas of Genetics and Cytogenetics in Oncology and Haematology, pp. 87–92, 2018, Accessed: 00, 2020. [Online]. Available: